hrp0082p1-d2-219 | Reproduction (1) | ESPE2014

Mutation Analysis of the KISS1, KISS1R, LIN28A, LIN28B, TAC3, and TACR3 Genes in Girls with Central Precocious Puberty

Kim Yoo-Mi , Hye Kim Ja , Hyang Cho Ja , Choi Jin-Ho , Yoo Han-Wook

Background: Central precocious puberty (CPP) is mostly idiopathic, however, familial cases of CPP and evidence of genetic factors on pubertal timing by genome-wide association studies suggested genetic causes of CPP.Objective and hypotheses: Molecular defects in six genes (KISS1, KISS1R, LIN28A, LIN28B, TAC3, and TACR3) have been known to cause early activation of the hypothalamic-pituitary–gonad...

hrp0082p2-d1-520 | Pituitary | ESPE2014

Hypothalamic Obesity in Children with Craniopharyngioma: Prevalence and Risk Factors of Obesity and Longitudinal Trends of BMI

Cho Ja Hyang , Kim Ja Hye , Kim Yoo-Mi , Choi Jin-Ho , Yoo Han-Wook

Background: Craniopharyngioma is the most common parasellar tumor in childhood arising from remnants of Rathke’s pouch. As the hypothalamus plays a vital role in regulation of body weight by balancing energy intake and expenditure, hypothalamic damage by structural lesions is one of the most common causes of hypothalamic obesity. This study investigated prevalence, risk factors for the development of hypothalamic obesity, and consequent morbidities in children following t...

hrp0084p2-287 | Diabetes | ESPE2015

Incidence of Type 1 Diabetes among Korean Children and Adolescents in 2012–2013: Analysis of Data from the Nationwide Registry of Korea

Kim Jae Hyun , Lee Young Ah , Yang Sei Won , Shin Choong Ho

Background: The incidence of type 1 diabetes mellitus (T1DM) in children and adolescents has increased worldwide. However, the epidemiology of T1DM among Korean children has not been reported since 2001.Objective and hypotheses: We therefore investigated the incidence of T1DM in Korean children and adolescents in 2012–2013 and compared it with data from 1995–2000.Method: Data were obtained from the National Health Insuran...

hrp0084p2-545 | Puberty | ESPE2015

Change of Growth Pattern and Bone Mineral Density in Ovariectomised Female Rats According to Oestrogen Dosage

Kang Byung Ho , Park Mun Suk , Yang You Jung , Lim Sung Jig , Shim Kye Shik

Objective and hypotheses: The purpose was to get the basic data of optimum serum concentration of oestrogen in pubertal growth spurt, minimising the decrease of bone mineral density or acceleration of epiphyseal closure of long bones.Method: i). Fifteen female S.D. rats (4-week aged) were ovariectomised to inhibit their endogenous oestrogen effect and randomly divided into three groups. After 1 week, the group 1 were injected subcutaneousl...

hrp0084p3-1106 | Pituitary | ESPE2015

Acquired Long QT Syndrome in a 14-year-old Boy with Panhypopituitarism

Kim Yoo-Mi , Seo Jung-Ho , Cheon Chong Kun , Yim Young-Tak , Kim Su Young

Background: Acquired QT prolongation can be caused by electrolyte abnormality, myocarditis, cerebrovascular disease, drug intoxication and hormonal disorders such as hypopituitarism, hypothyroidism, and adrenal insufficiency.Case presentation: We describe a 14-year-old boy with hypopituitarism after trans-sphenoidal surgery (TSS) due to suprasellar mass who manifested bradycardia and QT prolongation on electrocardiogram. This subject complained of blurre...

hrp0097p1-229 | Diabetes and Insulin | ESPE2023

Trajectories of glycemic control in transition-aged patients with type 1 diabetes

Jee Kim Min , Jeong Lee Yun , Ho Shin Choong , Ah Lee Young

Objectives: We investigated the trajectories in hemoglobin A1C (A1C) levels among transition-aged patients (age from 15 to 22 years) with type 1 diabetes (T1D).Methods: Among the patients diagnosed with type 1 diabetes in pediatric age between 2001 and 2013 in Seoul National University Children’s Hospital, 119 patients (54 males and 65 females) with a diagnostic age for under 14 and measurement of A1C at least once...

hrp0097p2-62 | Diabetes and Insulin | ESPE2023

Growth patterns according to glycemic control, CGM apply, and diabetic complications in type 1 diabetes mellitus patients

Suh Junghwan , Kim Sujin , Lee Myeongseob , Song Kyungchul , Kwon Ahreum , Wook Chae Hyun , Kim Ho-Seong

Introduction: Chronic diseases such as type 1 diabetes mellitus (T1DM) may alter linear growth, but previous reports regarding growth in children with T1DM has been inconsistent. This study aims to investigate height and growth velocity of T1DM patients after diagnosis of diabetes and whether they are affected by various factors.Methods: This retrospective study, included 151 patients (male, 45.0%; mean age at diagnosis,...

hrp0092p1-103 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

A Case of Panhipopituitarism with SOX3 Gene Deletion

Cinaz Peyami , Kayhan Gülsüm , Döğer Esra , Uğurlu Aylin Kılınç , Akbaş Emine Demet , Küpçü Zekiye , Perçin Ferda , Bideci Aysun , Çamurdan Orhun

Introduction: It is known that microduplications including the SOX3 gene and intragenic duplications leading to loss of function in the gene cause panhypopituitarism, which can be accompanied by intellectual failure. Here, we report the first known case of panhypopituitarism, a deletion of the X chromosome, including the SOX3 gene in the q27.1q27.3 region.Case: A 15-years and two months old male patient was referred to o...

hrp0089p1-p231 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P1 | ESPE2018

Altered Vascular Function in Boys with Hypospadias – Role of Reactive Oxygen Species

Lucas-Herald Angela K , Alves-Lopes Rheure , Haddow Laura , O'Toole Stuart , Basith Amjad S , Flett Martyn , Steven Mairi , Lee Boma , Montezano Augusto C , Faisal Ahmed Syed , Touyz Rhian M.

Background: Hypospadias in boys may be associated with a lack of androgen exposure during the masculinisation programming window. As testosterone has effects on the vasculature, we assessed whether boys with hypospadias show any evidence of vascular dysfunction.Methods: Excess foreskin tissue was obtained from boys undergoing hypospadias repair (cases) or circumcision (controls) and small arteries dissected from this tissue. Vascular contractility was as...

hrp0094fc6.2 | Bone and Mineral Metabolism | ESPE2021

Long-term effectiveness of PTH(1-34) infusion therapy for autosomal dominant hypocalcaemia type 1.

Sastre Ana , Valentino Kevin , Hannan Fadil M , Lines Kate E , Gluck Anna K , Stevenson Mark , Ryalls Michael , Gorrigan Rebecca , Pullen Debbie , Buck Jackie , Sankar Sailesh , Allgrove Jeremy , Thakker Rajesh V , Gevers Evelien F ,

Background: Patients with autosomal dominant hypocalcemia type 1 (ADH1), due to germline gain-of-function calcium-sensing receptor (CASR) mutations, have hypocalcemia and seizures, hyperphosphatemia, hypercalciuria and inappropriately low parathyroid hormone (PTH) concentrations. Treatment for ADH1 comprises calcium and vitamin D analogs, however, their use predisposes to nephrocalcinosis and renal impairment. In contrast, recombinant human PTH(1-34) may incre...