hrp0094p2-100 | Diabetes and insulin | ESPE2021

The knowledge and Confidence in Management of Diabetic Ketoacidosis (DKA) among Iraqi Paediatric Residents: a Cross Sectional Study

Alsaffar Hussain , Al-Jumaili Ali Hasan , Hadi Wasnaa ,

Introduction: Diabetic ketoacidosis (DKA) is a common medical emergency and is the most common cause of death in children with type 1 diabetes mellitus due its complications. Paediatric residents are usually the first line whom managing paediatric emergencies in Iraqi hospitals. They form the backbone of the provided service. It is important to make sure they are practicing at the highest possible standard to ensure patients’ safety. Therefore, it is cruc...

hrp0097p1-453 | Fat, Metabolism and Obesity | ESPE2023

Echocardiographic assessment of periaortic fat thickness and its relationship to cardiovascular risk factors in children with simple obesity

Abdelghaffar Shereen , M. Fattouh Aya , Ali Mohamed Ola , Arafa Noha

Key words: Childhood, Obesity, Periaortic fat thickness, Echocardiography, Cardiovascular risk.Aim: To assess the periaortic fat thickness (PAFT) by echocardiograpy in a cohort of children with simple obesity and to evaluate its relationship to clinical and metabolic cardiovascular risk factors.Methods: Fifty children and adolescents with simple obesity and 25 healthy sex and age m...

hrp0098p3-75 | Diabetes and Insulin | ESPE2024

A Double Enigma: Co-existing Congenital Hypothyroidism and Autosomal Recessive Familial Hyperinsulinemic Hypoglycemia in a Neonate

Rai Versha , Ali Sanagar , Noor Ibrahim Mohsina , Riaz Maira

Congenital hypothyroidism (CH) and hyperinsulinemic hypoglycemia represent two distinct yet interrelated metabolic disorders in pediatric endocrinology. We report a comprehensive case study of a 14-day-old female neonate presenting with persistent hypoglycemia since birth, despite initial management with thyroxine for suspected CH. The neonate exhibited classical clinical features of CH, including lethargy, puffy face, and umbilical hernia, alongside a pertinent family history...

hrp0082p3-d3-800 | Gonads and Gynaecology | ESPE2014

Ovarian Tumors Observed in Endocrinology

Laloui Amina , Fedala Soumeya , Haddam Ali El Mahdi , Chentli Farida , Meskine Djamila , Ali Leyla Ahmed , Yaker Fetta Amel

Background: Ovarian tumors are rare in the pediatric age and are represented primarily by functional cysts and benign tumors, the most common is the mature teratoma.Objective and hypotheses: Assess clinical, radiological, etiological and scalable characteristics of ovarian tumors in the pediatric age.Method: Retrospective study of seven cases of ovarian tumors collected over a period of 20 years. All children received complete clin...

hrp0084p2-179 | Adrenals | ESPE2015

Primary Adrenal Insufficiency: About a Paediatric Series

Nardine Imen , Fedala Nora Soumeya , Derghoum Boubker , Ali Leyla Ahmed , Haddam Ali El Mahdi , Meskine Djamila , Chentli Farida

Background: Adrenal insufficiency in children is rare and potentially serious because of the risk of acute adrenal insufficiency. This complication is lethal in the absence of prompt and appropriate treatment. Aetiologies are dominated by the genetic causes.Objective and hypotheses: Report diagnostic circumstances,phenotypic forms and causes of adrenal insufficiency in children and adolescents.Method: This is a retrospective study ...

hrp0095p1-173 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

Differences due to the variant type in the inheritance pattern of BMP15 gene-related primary ovarian insufficiency: a girl with a homozygous null BMP15 gene variant

Yavas Abali Zehra , Arslan Ates Esra , Eltan Mehmet , Gurpinar Tosun Busra , Bereket Abdullah , Guran Tulay , Turan Serap

Background: Bone morphogenetic protein 15 (BMP15), is an oocyte-specific growth factor, that regulates folliculogenesis and ovulation rate. It is encoded by the BMP15 gene (chromosome Xp11.2), in which heterozygous missense variants in the precursor or mature peptide cause primary ovarian insufficiency (POI) with the dominant-negative effect. BMP15-related ovarian dysgenesis (OD) constitutes 1.5-2.0% of POI. The underlying mechanism ...

hrp0095p1-367 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

Evaluation of The Relationship Between the Immune and Endocrine System in Children Diagnosed with Polycystic Ovary Syndrome

Uygur Balık Ahmet , Keskin Mehmet , Karaoglan Murat , Keskin Ozlem , Yıldırım Ahmet , Albayrak Serpil

Polycystic ovary syndrome is the most common endocrinological disease in women of reproductive age. Although it is thought that pathologies such as insulin resistance, chronic low-level inflammation and hyperandrogenism are central theme of the disease, the exact pathophysiology of the disease has not been fully understood. This study’s aim is to reveal the relationship between routine endocrinological and immunological markers related to chronic inflammation, and to inv...

hrp0089p3-p010 | Adrenals and HPA Axis P3 | ESPE2018

Lipoid Adrenal Hyperplasia Diagnosed with Severe Cholestasis in Newborn

Kaplan Emel Hatun Aytac , Melekoğlu Nuriye Aslı , Keskin Mehmet , Cağatay Derya , Karaer Kadri

Introduction: Congenital lipoid adrenal hyperplasia is the most severe form of congenital adrenal hyperplasia and is rarely seen. Steroid synthesis cannot be done in the adrenal gonads. Adrenal glands have hyperplasia and lipid accumulation. Male babies are born to girls. Most of the cases are lost with severe adrenal insufficiency. Patients diagnosed and treated at supraphysiological doses during neonatal period. Here we present a case of lipoid adrenal hyperplasia diagnosed ...

hrp0089p3-p021 | Adrenals and HPA Axis P3 | ESPE2018

Presenting Features, Clinical Characteristics and Follow up of Familial Isolated Glucocorticoid Deficiency (FGD) due to Mutations in MC2R and MRAP Genes

Ozbek Mehmet Nuri , Karaşin Nezehat Doğan , Demirbilek Huseyin , Demiral Meliha , Baran Rıza Taner , Guran Tulay

Objectives: Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder characterized with isolated glucocorticoid deficiency. Melanocortin receptor 2 (MC2R) mediates the functions of adrenocorticotropic hormone (ACTH) in the adrenal cortex. MC2R accessory protein (MRAP), a transmembrane protein, involves in the trafficking of MC2R to the cell surface. Mutations in MC2R and MRAP genes cause FGD type 1 and 2. Herein, we ev...

hrp0089p2-p193 | Fetal, Neonatal Endocrinology and Metabolism P2 | ESPE2018

A Rare Cause of Hyperinsulinemic Hypoglycemia: Costello Syndrome

Vuralli Dogus , Kosukcu Can , Taskiran Ekim , Ozlem Simsek Pelin , Eda Utine Gulen , Boduroglu Koray , Alikasifoglu Ayfer , Alikasifoglu Mehmet

Introduction: Costello syndrome is a rare RASopathy that is associated with such characteristics as prenatal overgrowth, postnatal growth retardation, mental-motor retardation, coarse face appearance, loose skin on the neck, hands and feet, cardiovascular abnormalities, deep palmar and plantar lines and a predisposition to various types of cancer. Several endocrine disorders, including growth hormone deficiency, adrenal failure, glucose intolerance, hyperprolactinemia and hypo...