hrp0098p1-212 | Adrenals and HPA Axis 3 | ESPE2024

Negative Impact of Supraphysiological Glucocorticoid Dosing on Growth and Changes in Glucocorticoid Dose and Androstenedione Health States in Patients with Classic Congenital Adrenal Hyperplasia: Results from the CAHtalog™ Patient Registry

Lekarev Oksana , Sen Ginny , Haider Mahroz , Tang Fei , Friedler Haley , Chen Joy , Lin-Su Karen , Matos Dina , Dessibourg Jackie , Cheng Henry , Roberts Eiry , Chan Jean , Jeha George

Introduction: Patients with classic congenital adrenal hyperplasia (CAH) require glucocorticoid (GC) therapy to replace cortisol insufficiency and reduce excess adrenal androgens, usually necessitating supraphysiologic GC doses. CAHtalog™, developed in partnership with CARES Foundation using the PicnicHealth platform, is a real-world US patient registry that characterizes the natural history of classic CAH. This study explored changes in health states ba...

hrp0098p1-230 | Diabetes and Insulin 4 | ESPE2024

Screening for Dysglycaemia in Children Amidst a Global Obesity Crisis

Sims Jack , Worth Chris , Chinoy Amish , Manfredonia Claire , Ginbey Eleanor , Skae Mars

Background: The incidence of Type 2 Diabetes Mellitus (T2DM) among children is escalating at an alarming rate, presenting a significant public health concern. This increase is intrinsically linked to the obesity epidemic, with most children diagnosed with T2DM being overweight or obese. While the oral glucose tolerance test (OGTT) remains the gold standard for diagnosing T2DM (and the preceding dysglycaemia), its accessibility and practicality in community set...

hrp0098p2-42 | Bone, Growth Plate and Mineral Metabolism | ESPE2024

The etiological distribution of elevated serum alkaline phosphatase levels and characteristics of children with transient hyperphosphatasemia

Bahar Balaban Berber İlkay , Öztürk Sercan , Güneş Sebla , Tekneci Ayşegül , Ünüvar Tolga , Anik Ahmet

Objective: Elevated serum alkaline phosphatase (ALP) levels in pediatric patients can result from various etiologies, with transient hyperphosphatasemia, bone pathologies, and hepatic diseases being the most common. This study aimed to elucidate the etiological factors responsible for elevated ALP levels and to evaluate the clinical presentations of transient hyperphosphatasemia in these patients.Materials and Methods: T...

hrp0098p2-114 | Fat, Metabolism and Obesity | ESPE2024

The Association between Metabolic markers, Liver function enzymes, Vitamin D level, and Lung Function Tests in Overweight/obese Children with and without Asthma

Noor Safa , Hamdoun Elwaseila , Shailesh Harshita , Hani Yahya , Belavendra Antonisamy , Hasabelgawi Lina , Janahi Ibrahim

Introduction: The coexistence of asthma and obesity presents a significant clinical challenge, as both conditions independently contribute to systemic inflammation, metabolic dysregulation, and impaired respiratory function. Metabolic markers can potentially provide insights into the pathophysiological mechanisms that link obesity and asthma. The aimof this study was to investigate the association between metabolic markers, vitamin D and lung function in child...

hrp0098p2-197 | Growth and Syndromes | ESPE2024

Adult height of children born small for gestational age treated with growth hormone in southern Brazil

Eduardo Cruvinel Luís , Cardoso-Demartini Adriane , Kraemer Gabriela , Pereira Rosana , Nesi-Franca Suzana , Carvalho Julienne

Introduction: Children born small for gestational age (SGA) may present permanent short stature. Recombinant human Growth Hormone (rhGH) treatment is recommended for those without spontaneous catch-up growth, however it is not universally available in the Brazilian health care system. Response to treatment may be different across populations since there are many etiologies to SGA birth.Objective: to evaluate adult height...

hrp0098p2-324 | Late Breaking | ESPE2024

HOMA and Matsuda Index as Screening Tests for Cystic Fibrosis Associated Diabetes in Children

Albayrak Serpil , Arık Elif , Keskin Ozlem , Karaoglan Murat , Keskin Mehmet , Inal Gaye , Cesur Mahmut , Küçükosmanoğlu Ercan , Yıldırım Ahmet

Objective: Cystic fibrosis (CF) associated diabetes (CFRD) is a common comorbid condition in individuals with CF and its prevalence increases with age. There are reports in children aged 10 years and younger. The aimof this study was to estimate insulin resistance by HOMA-IR (Homeostatic Model Assessment) with oral glucose tolerance test (OGTT) data and Matsuda index to test glucose metabolism in relation to Matsuda insulin secretion in children with CF.<p...

hrp0098p2-354 | Late Breaking | ESPE2024

The IGF1 generation test as a tool to predict growth response to growth hormone treatment in children with growth hormone deficiency

Kherra Sakina , Ouarezki Yasmine , Djermane Adel , Sahli Hassiba , Sifour Latifa , Bellouti Sihem , Mohamedi Kahina , Boutaghane Noureddine , Bouferoua Fadila , Bensalah Meriem , Ladjouze Asmahane , Ait abdelkadder Belaid , Coutant Régis , Zoulikha Zeroual

Introduction: Serum levels of insulin growth factor (IGF1) could be a good indicator of growth hormone (GH) sensitivity and potentially GH therapy responsiveness. Few studies analyzed IGF1 generation test as predictor factor of the growth response to GH treatment in children with growth hormone deficiency (GHD) but results were controversial.Objective: The aimof the study was to evaluate the IGF-I generation test (IGF-I ...

hrp0098p3-101 | Fat, Metabolism and Obesity | ESPE2024

Correlation of body mass index and insulin resistance in obese and overweight children and adolescents - a single center study

Jakovljevic Milica , Stojkovic Milica , Cvetkovic Vesna , Stankovic Sandra

Introduction: According to World Health Organization, in 2022 over 429 millions of children were obese. Insulin resistance is a resistance to the effects of insulin on glucose metabolism and measured by Homeostasis model assessment- Insulin resistance index (HOMA-IR). Previous studies suggested a correlation between body mass index (BMI) for age and sex with HOMA IR and advised using BMI as a surrogate marker for insulin resistance.<stro...

hrp0084p3-770 | Diabetes | ESPE2015

Particularités de la prise en charge du diabète Type 1 chez des enfants dont la révélation est survenue avant l’âge de five ans

Wafaa Mazari , Khadidja Bouriche , Djawida Senouci , Yasmine Zerga , Snaa Chiali , Salih Bendeddouche

Introduction: Le diabète de type 1 est l’endocrinopathie la plus fréquente chez l’enfant. Son incidence est en nette progression dans le monde. L’enfant diabétique nécessite une hygiène de vie adaptée et le suivi par une équipe pluridisciplinaire composée de pédiatre spécialiste en diabétologie, psychologue, diététicien, infirmier spécialisé.Objectif: Determiner les...

hrp0095rfc4.2 | Fat, Metabolism and Obesity | ESPE2022

Effect of Setmelanotide Treatment in Children and Adolescents With Proopiomelanocortin (POMC) Deficiency, Leptin Receptor (LEPR) Deficiency, and Bardet-Biedl Syndrome (BBS)

Argente Jesús , Kühnen Peter , M. Haqq Andrea , Wabitsch Martin , K. Chung Wendy , van den Akker Erica , Á. Martos-Moreno Gabriel , Mohamed Iqbal Anoop , Forsythe Elizabeth , Dubern Béatrice , Malhotra Sonali , Yuan Goujun , Touchot Nicolas , Dollfus Hélène , Farooqi Sadaf , Clément Karine

Background: The melanocortin-4 receptor (MC4R) pathway is a key regulator of energy balance and satiety. Variants in genes upstream of MC4R encoding leptin receptor (LEPR), proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1(PCSK1) and those involved in Bardet-Biedl syndrome (BBS) can impair MC4R pathway signaling. Clinically, these variants are characterized by hyperphagia (Pathologic insatiable hunger) and early-onset, severe obesity. E...