ESPE Abstracts

Introduction: Patients with classic congenital adrenal hyperplasia (CAH) require glucocorticoid (GC) therapy to replace cortisol insufficiency and reduce excess adrenal androgens, usually necessitating supraphysiologic GC doses. CAHtalog™, developed in partnership with CARES Foundation using the PicnicHealth platform, is a real-world US patient registry that characterizes the natural history of classic CAH. This study explored changes in health states ba...

Background: The incidence of Type 2 Diabetes Mellitus (T2DM) among children is escalating at an alarming rate, presenting a significant public health concern. This increase is intrinsically linked to the obesity epidemic, with most children diagnosed with T2DM being overweight or obese. While the oral glucose tolerance test (OGTT) remains the gold standard for diagnosing T2DM (and the preceding dysglycaemia), its accessibility and practicality in community set...

Objective: Elevated serum alkaline phosphatase (ALP) levels in pediatric patients can result from various etiologies, with transient hyperphosphatasemia, bone pathologies, and hepatic diseases being the most common. This study aimed to elucidate the etiological factors responsible for elevated ALP levels and to evaluate the clinical presentations of transient hyperphosphatasemia in these patients.Materials and Methods: T...

Introduction: The coexistence of asthma and obesity presents a significant clinical challenge, as both conditions independently contribute to systemic inflammation, metabolic dysregulation, and impaired respiratory function. Metabolic markers can potentially provide insights into the pathophysiological mechanisms that link obesity and asthma. The aimof this study was to investigate the association between metabolic markers, vitamin D and lung function in child...

Introduction: Children born small for gestational age (SGA) may present permanent short stature. Recombinant human Growth Hormone (rhGH) treatment is recommended for those without spontaneous catch-up growth, however it is not universally available in the Brazilian health care system. Response to treatment may be different across populations since there are many etiologies to SGA birth.Objective: to evaluate adult height...

Objective: Cystic fibrosis (CF) associated diabetes (CFRD) is a common comorbid condition in individuals with CF and its prevalence increases with age. There are reports in children aged 10 years and younger. The aimof this study was to estimate insulin resistance by HOMA-IR (Homeostatic Model Assessment) with oral glucose tolerance test (OGTT) data and Matsuda index to test glucose metabolism in relation to Matsuda insulin secretion in children with CF.<p...

Introduction: Serum levels of insulin growth factor (IGF1) could be a good indicator of growth hormone (GH) sensitivity and potentially GH therapy responsiveness. Few studies analyzed IGF1 generation test as predictor factor of the growth response to GH treatment in children with growth hormone deficiency (GHD) but results were controversial.Objective: The aimof the study was to evaluate the IGF-I generation test (IGF-I ...

Introduction: According to World Health Organization, in 2022 over 429 millions of children were obese. Insulin resistance is a resistance to the effects of insulin on glucose metabolism and measured by Homeostasis model assessment- Insulin resistance index (HOMA-IR). Previous studies suggested a correlation between body mass index (BMI) for age and sex with HOMA IR and advised using BMI as a surrogate marker for insulin resistance.<stro...

Introduction: Le diabète de type 1 est l’endocrinopathie la plus fréquente chez l’enfant. Son incidence est en nette progression dans le monde. L’enfant diabétique nécessite une hygiène de vie adaptée et le suivi par une équipe pluridisciplinaire composée de pédiatre spécialiste en diabétologie, psychologue, diététicien, infirmier spécialisé.Objectif: Determiner les...

Background: The melanocortin-4 receptor (MC4R) pathway is a key regulator of energy balance and satiety. Variants in genes upstream of MC4R encoding leptin receptor (LEPR), proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1(PCSK1) and those involved in Bardet-Biedl syndrome (BBS) can impair MC4R pathway signaling. Clinically, these variants are characterized by hyperphagia (Pathologic insatiable hunger) and early-onset, severe obesity. E...