ESPE Abstracts

ESPE Abstracts

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hrp0098s3.2 | Novel Advances in the Treatment of Hypothalamic disease | ESPE2024

Use of MC4R agonist in hypothalamic obesity

Argente Jesús

Clinical and experimental evidence supports the important contribution of brain circuits in the pathogenesis of obesity. While functional perturbation of hypothalamic pathways could underlie common forms of obesity, the term “hypothalamic obesity” has been coined to define rare forms of severe overweight where a clear hypothalamic substrate, either genetic or acquired, can be identified. Addressing the problem of early-onset, severe obesity in children is of utmost...
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hrp0098p1-34 | Diabetes and Insulin 2 | ESPE2024

SEXUAL KNOWLEDGE AND CONTRACEPTIVE USE IN ADOLESCENTS WITH TYPE 1 DIABETES IN COMPARISON WITH THEIR HEALTHY PEERS

Paltoglou George , Kandyla Betina , Tsitsika Artemis , Tzavara Chara , Soldatou Alexandra , Karanasios Spyridon , Kossiva Lydia , Karavanaki Kyriaki

Introduction: Adolescents with type 1 diabetes mellitus (T1D) may differ from their healthy peers in respect to sexually transmitted diseases (STDs) knowledge and contraceptive use.Objectives: We aimed to explore sexual knowledge and contraceptive use and associated factors in T1D adolescents compared to healthy peers.Methods: Fifty-eight T1D adolescents (mean±SD age 16.3±2.0...
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hrp0098p1-100 | Thyroid 1 | ESPE2024

Evaluating Malignancy in Pediatric Thyroid Nodules: The Effectiveness of the Bethesda System and TIRADS

Gazek Natalia , Suarez Mozo Melissa , Celeste Mattone Maria , Santana Olivares Jesus , Ciaccio Marta , Dujovne Noelia

Introduction: The risk of malignancy of pediatric thyroid nodules is determined according to the Bethesda System. Biopsy is performed by fine needle aspiration (FNA) based on ultrasonography (US) patterns. To identify suspicious nodules in adults, the Thyroid Imaging Reporting and Data System (TI-RADS) is widely used; however, its use in pediatrics is less common.Aim: To analyze the usefulness of the Bethesda system and ...
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hrp0098p1-186 | Pituitary, Neuroendocrinology and Puberty 3 | ESPE2024

Utility of First-Morning-Voided Urinary Total LH in Detecting the Onset of Central Puberty

Demir And , Hero Matti , Main Katharina , Juul Anders

Introduction: Early morning basal serum luteinizing hormone LH) (S-LH) ≥ 0.3 IU/L is a specific marker for the onset of central puberty. In this study, we aimed to investigate the sensitivity and specificity of the first-morning-voided (FMV) total urinary LH (U-LH) to replace this marker.Methods: We re-analyzed our previously published data set of 297 children (145 boys and 152 girls, aged 5-15 years, across Tanner st...
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hrp0098p1-229 | Diabetes and Insulin 4 | ESPE2024

Nighttime Blood Pressure Disturbances in Children with Long-Term Type 1 Diabetes

Stepniewska Anna , Szczudlik Ewa , Drozdz Dorota , Wojcik Malgorzata , Nazim Joanna , Janus Dominika , Starzyk Jerzy

Background: Arterial hypertension (AH) in young patients with Type 1 Diabetes (T1D) occurs more often, and at younger age than in general population. A reduction of nighttime dip value is considered as an early marker of AH risk.The aim of this study: was to identify the association between AH, and abnormal nighttime dip and diabetes-related factors: duration time and glycemic controlMethod...
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hrp0098p2-196 | Growth and Syndromes | ESPE2024

Early life growth patterns in cystic fibrosis in Infants from western Algeria

Oussalah Meriem , Rezak Radia , Aichaoui Malika , Leila Khelil Amina

Background: If in European and American countries we have very clear statistics about growth in Cystic fibrosis (CF). It is not the same in the majority of African countries because it has long been considered as a very rare pathology there. Actually without newborn screening; CF is under-diagnosed and given the fatal nature of the disease, many patients are lost.Objective: describe the anthropometric parameters of infan...
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hrp0098p2-378 | Late Breaking | ESPE2024

Serum vascular endothelial growth factor-A (VEGF-A) levels regarding pubertal stage and obesity in girls

Nam Hyo-Kyoung , Kang Eungu , Jun Rhie Young , Lee Kee-Hyoung Kee-Hyoung

Objectives: Vascular endothelial growth factor-A (VEGF-A) is essential for normal growth plate morphogenesis and angiogenesis in adipose tissue. Childhood obesity may lead to early puberty in girls, however, it remains unclear whether early thelarche in overweight girls is related to central activation of the gonadotropin releasing hormone-gonadotropin axis. We assessed serum VEGF-A level regarding to pubertal stage and obesity in girls....
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hrp0095fc8.1 | Diabetes and Insulin | ESPE2022

Clinical effectiveness of Liraglutide 3.0 mg for weight management as an adjuvant therapy in obese adolescents with type 1 diabetes: A single-center pilot study

Elbarbary Nancy

Background: Recent data from multiple international registries showed higher rates of overweight and obesity in adolescents with type 1 diabetes (T1DM) compared with their non-diabetic peers. Management of weight gain should be emphasized as obesity is a modifiable cardiovascular risk factor. Liraglutide is a glucagon like peptide‐1 receptor agonist approved for chronic weight management in adolescents with body weight above 60 kg and body mass index (BMI...
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hrp0095rfc9.1 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

The Incidence of Congenital Combined Pituitary Hormone Deficiency in Denmark - a national observational study

Kjersgaard Jakobsen Louise , Beck Jensen Rikke , Holtum Birkebæk Niels , Hansen Dorte , Rønholt Christensen Ann-Margrethe , Thybo Christesen Henrik

Background: Congenital combined pituitary hormone deficiency (cCPHD) is the loss of ≥2 pituitary hormones caused by genetic or prenatal factors.Methods: For the period 1996–2020, patients with cCPHD were identified from the Danish National Patient Registry and the registries at the four Danish hospitals approved for the management of cCPHD. Retrospective hospital file reviews were performed to validate the diagn...
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hrp0095t12 | Section | ESPE2022

Assessment of non-alcoholic fatty liver disease with non-invasive indices in adolescents with polycystic ovary syndrome

Context: Polycystic ovary syndrome (PCOS) is a complex disorder affecting women from adolescence until menopause. PCOS in adolescent years shares common features with clinical presentation in adulthood, including the adverse metabolic profile. Non-alcoholic fatty liver disease (NAFLD) is a spectrum of hepatic changes, from liver steatosis to severe inflammation and fibrinogenesis.Objective: To assess NAFLD in an adolesce...
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