ESPE Abstracts

Background: Obesity in childhood and adolescence represents a major health problem of our century, and accounts for a significant increase in morbidity and mortality in adulthood.Objective and hypotheses: To investigate the effectiveness of a comprehensive and personalized plan of action in the prevention and management of overweight and obesity in childhood and adolescence.Method: 470 children and adolescents (mean age±SEM: 9...

Introduction: Classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is a rare, autosomal disorder characterized by deficiency of cortisol and oftentimes aldosterone, elevated adrenocorticotropic hormone (ACTH), and excess androgen production. In a phase 2 study of adolescents with classic 21OHD, 14 days of treatment with the corticotropin-releasing factor type 1 receptor (CRF1) antagonist, crinecerfont, led to median percent red...

Introduction: Carney Complex is a rare genetic disorder inherited in an autosomal dominant manner or may occur sporadically due to de novo mutations. It is characterized by the presence of cardiac myxomas, psammomatous melanotic schwannomas, skin pigmentation (blue nevi, lentigines) and multiple endocrine and non- endocrine tumors. It is caused by inactivating mutations or large deletions of the PRKAR1A gene. Management of the syndrome involves ongoing surveil...

Background: Congenital Hyperinsulinism (CHI) is a rare condition that represents a substantial burden to affected children, their families and the health service (~£3.5 million annually).1–3 CHI is demanding, unpredictable and requires constant hypervigilance to minimise the risk of neurodisability and death. Rapid technological advancements in continuous glucose monitoring (CGM) have revolutionised blood glucose management for children ...

Key words: Descriptive study, short stature, Growth Hormone deficiency, Growth Hormone analogue, Lebanon, NDS-UMC, Byblos, single center experience.Background: There is a lack of national data concerning growth hormone deficiency treatment in Lebanon. The aim of this study is to describe the height gained under growth hormone therapy of 39 patients diagnosed with growth hormone deficiency (GHD).<st...

Background: Allgrove syndrome (AS) is a rare autosomal recessive disease characterized by alacrimia, achalasia, adrenal insufficiency and variable autonomic, central or peripheral nervous system dysfunction due to (AAAS) gene mutation on 12q13 coding ALADIN protein. Simultaneous onset of all clinical features is not a rule. Alacrimia is the earliest and constant symptom presenting since birth. However, achalasia is the most common complaint bringing children t...

Background: Acute Lymphoblastic Leukemia (ALL) is the most common pediatric oncologic disease. Nowadays, ALL has become a treatable disease due to a well designed chemotherapy protocol. L-Asparaginase is an essential drug which has improved the long term outcome of ALL. However, hyperglycemia due to L-Asparaginase (4-20%) and PEG- Asparaginase (4-17%) is one side effect and can lead to diabetes mellitus or even to diabetic ketoacidosis DKA (0.8%) in combinatio...

Background: Celiac disease (CD) is a chronic immune-mediated intestinal inflammatory disease due to gluten intolerance in genetically predisposed patients leading to mal-absorption followed by short stature, frequently associated to immune-mediated diseases (IDDM, autoimmune-thyroiditis, Addisson), syndromes (Down, Williams, Turner, selective IgA deficiency) and increased risk of non-Hodgkin and T-cell lymphoma. Its diagnosis is based on serological antibodies...

Treatment with Recombinant Human GH (rhGH) has been of significant value in promoting quality of life in children with GH deficiency. However, it has been associated with several side-effects in the literature, including hypothyroidism, usually transient during the replacement therapy. The aim of this study was to evaluate the side effects of hGH replacement therapy, among children who were followed up at the Pediatric Endocrinology Outpatients Unit of our hospital during the ...

Background: A common cause of neurodevelopmental impairment in children is congenital hypothyroidism, but can be preventable with adequate screening and proper management. Preterm newborns are more likely to have thyroid dysfunction, with small for gestational age (SGA) being an additional risk factor. However, only few studies addressed the altered thyroid hormone concentrations in the first few weeks of life concluding that Thyroid-Stimulating Hormone (TSH) levels are higher...