hrp0089p1-p210 | Pituitary, Neuroendocrinology and Puberty P1 | ESPE2018

Hypothalamic-pituitary-testicular Axis Response to Sub-maximal Aerobic Exercise, in Pre- and Early- Pubertal Normal Weight and Obese Boys

Paltoglou George , Avloniti Alexandra , Chatzinikolaou Athanasios , Mantzou Aimilia , Stefanaki Charikleia , Papagianni Maria , Fatouros Ioannis , Mastorakos Ge

Objective: To investigate the association of the gonadal axis with pro- and anti- oxidation, in relation to obesity and pubertal status in boys, before and after a stimulatory exercise bout.Design: Cross-sectional human experimental study.Methods: Ninty-two healthy normal-weight and obese pre- and early- pubertal boys, participated in this study. All subjects underwent a baseline blood sampling followed by an aerobic exercise bout ...

hrp0086p1-p196 | Diabetes P1 | ESPE2016

Development of Type 1 Diabetes in a Child with Inherited CD59 Deficiency Treated with Eculizumab

Koca Serkan Bilge , Ozon Alev , Alikasifoglu Ayfer , Haliloglu Goknur , Topaloglu Haluk

Background: CD59 is a complement regulatory protein which inhibits membrane attack complex protecting self-cells from complement-mediated damage. Recent evidence suggests CD59 may suppress T cell activation via a complement-independent mechanism. Other than an immune regulator, CD59 is shown to regulate glucose stimulated insulin secretion. Herein we report a patient with inherited CD59 deficiency who developed type 1 diabetes.Case: 11 year-old girl was ...

hrp0084p2-265 | Diabetes | ESPE2015

Importance of Thrombocyte Volume Parameters in Type 1 Diabetes Mellitus Patients with and without Clinical Findings of Diabetic Ketoacidosis

Vuralli Dogus , Aksoy Hatice Tatar , Yilmaz Arzu , Engiz Ozlem , Dallar Yildiz Bilge

Background: Thrombocyte volume parameters such as mean thrombocyte volume (MPV) and PDW (thrombocyte distribution volume) are parameters used in evaluation of thrombocyte size which have hemostatic importance. The increased thrombocyte volume is a marker of thrombocyte activation. The thrombocyte activity is important in pathophysiology of diseases with a tendency of thrombosis and inflammation. In adult studies it has been reported that MPV increases in thrombotic diseases su...

hrp0084p2-527 | Puberty | ESPE2015

Evaluation of Final Height in Girls Taking GnRH Analogue: Should the Age Limit for Precocious Puberty be Changed?

Vuralli Dogus , Dallar Yildiz Bilge , Tapci Esra , Engiz Ozlem , Simsek Enver

Background: The age limit for precocious puberty (PP) in girls is a topic that continues to be debated, and there is a new trend that supports the idea that the beginning of breast development in girls between ages 6 and 8 should not be accepted as true PP and it is necessary to label this clinical condition as accelerated puberty or early normal puberty.Objective and hypotheses: The aim of the current study is to determine the diagnostic criteria for gi...

hrp0084p3-855 | Fat | ESPE2015

Plasminogen Activator Inhibitor-1 as a Marker of Insulin Resistance in Obese Adolescents

Engiz Ozlem , Alioglu Bulent , Bagrul Denizhan , Karakaya Jale , Dallar Yildiz Bilge

Background: Obesity is considered to be a chronic inflammatory state in which the dysfunction of adipose tissue plays a central role. Adipose tissue is known to express and secrete a variety of products known as ‘adipokines’ including leptin, adiponectin, resistin, and visfatin, as well as cytokines and chemokines such as tumor necrosis factor-α (TNF-α), interleukin-6, and monocyte chemoattractant protein-1.Objective and hypotheses: T...

hrp0084p3-1151 | Puberty | ESPE2015

Urinary Bisphenol A and Its Relation with Kisspeptin in Girls with Idiopathic Central Puberty Precocious and Premature Telarche

Ozgen Ilker Tolga , Torun Emel , Bayraktar-Tanyeri Bilge , Durmaz Erdem , Cesur Yasar

Background: Endocrine disruptors cause harmful effects to human body through various exposure routes. These chemicals mainly appear to interfere with the endocrine or hormone systems. Bisphenol A (BPA) is known as an endocrine disruptor with an estrogenic effect and it is supposed that it may have a role on development of precocious puberty (PP). Kisspeptin, a hypothalamic peptide, is a neuromodulator of GnRH and it has a big role on regulation of the onset of puberty.<p c...

hrp0097fc2.6 | Bone, Growth Plate and Mineral Metabolism | ESPE2023

Human breast milk-derived exosomes promote growth plate cell lines in vitro

Eren Simge , Kabataş Bilge , Ünsal Naz , Yıldırım Merve , Eren Olcay

Introduction: Human breast milk (HBM) contains various components with critical roles in supporting early human growth and development. HBM is highly enriched in miRNAs, short, non-coding RNAs of 18 to 25 nucleotides in length, involved in the development, differentiation, proliferation, metabolism, and death of cells and tissues. miRNAs have been linked to growth control, apoptosis, epigenetic modifications, developmental programming, stem cell differentiatio...

hrp0097rfc9.6 | Diabetes and insulin 2 | ESPE2023

Wharton jelly derived mesenchymal stem cells exosomes protect pancreatic beta cells from inflamation

Eren Simge , Yıldırım Merve , Kabataş Bilge , Ünsal Naz , Eren Olcay

Background: Type 1 diabetes is an autoimmune disease initiated by the invasion of pancreatic islets by immune cells that selectively kill the β cells. The loss of beta cells in Type I diabetes ultimately leads to insulin dependence and major complications that are difficult to manage by insulin injections. Regulation of immune response is a key strategy to control the autoimmunity in diabetic patients. Mesenchymal stem cells have been shown to have an app...

hrp0097p2-265 | Late Breaking | ESPE2023

in vitro metabolic homeostatic activity of brown adipose tissue-derived exosomes

Kabataş Bilge , Eren Simge , Yıldırım Merve , Ünsal Naz , Eren Olcay

Introduction: Obesity and related metabolic diseases occur as a chronic imbalance between energy intake and energy expenditure. Due to its high metabolic activity, brown adipose tissue (BAT) has become a promising target for the development of new treatment concepts for metabolic disease. Having a high concentration of mitochondria, BAT is necessary to control the entire energy metabolism of the body. BAT consumes significant amounts of glucose and fatty acids...

hrp0098fc2.2 | Bone, Growth Plate and Mineral Metabolism | ESPE2024

Therapeutic Effects of Human Bone Marrow Mesenchymal Stem Cells Derived Exosomes on Glucocorticoid-Induced Osteoporosis: In Vitro Model

Eren Simge , Ünsal Naz , Kabataş Bilge , Yıldırım Merve , Eren Olcay

Introduction: Glucocorticoid-induced osteoporosis is the most frequent cause of secondary osteoporosis. Glucocorticoids are known to diminish β-catenin activity via Wnt pathway signaling, leading to osteoporosis and osteonecrosis. Bone homeostasis depends on the regulation of β-catenin in osteoblasts. Disruption of bone homeostasis, oxidative stress and mitochondrial dysfunction are major causes of glucocorticoid-induced osteoporosis; therefore, alle...