hrp0092p2-204 | Multisystem Endocrine Disorders | ESPE2019

Electromagnetic Fields Exposure in Adolescents: A Survey in 11-14 y Old Greek Students

Geronikolou Styliani , Chrousos George , Kanaka-Gantenbein Christina

Background: Electromagnetic field (EMF) exposure has been considered a potential environmental toxicant, which may influence endocrine and other functions, while population awareness remains limited. In an earlier study, we demonstrated that EMF alters the hypothalamic-pituitary-adrenal axis in children using a 3G mobile telephone.Aim: To screen and compare the motives, knowledge and status of electromagnetic field expos...

hrp0089p3-p279 | Multisystem Endocrine Disorders P3 | ESPE2018

Near Electromagnetic Fields – Induced Syndrome: Unsuspected and Newly Recognised

Geronikolou Styliani , Chrousos George , Kanaka-Gantenbein Christina

This present study investigates the impact of a common environmental hazard, the radiofrequency fields (RF), such as those regarding cell phones, cell phone base stations, wi-fi, portable phones (DECT), etc., as close to the body sources of exposure, on endocrine function. This is of importance, particularly for developing children, that have been and are exposed to this potential hazard. We performed analyses on endocrine assessments regarding stress, thyroid hand reproductiv...

hrp0095p1-181 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

Monoallelic variants in Myelin Regulatory Factor (MYRF) associated with 46,XY DSD – two cases and first report of inheritance through parental mosaicism

Kaninde Abhidhamma , Chandran Harish , McCarthy Liam , Ghose Arun , Ellis David , Fulton Piers , Vogt Julie , Igbokwe Rebecca , Jeremy Kirk Jeremy , Mohammed Zainaba , Idkowiak Jan

Background: Haplo-insufficiency of the Myelin-Regulatory Factor (MYRF) gene causes cardiac-urogenital syndrome (CUGS) and Differences in Sexual Development (DSD) in 46,XY and 46,XX (OMIM #618280). The gene product, a transcription factor, is involved in development of Coelomic epithelium derived cells, and likely causative for DSD. To date, only a few MYRF de novo variants are reported in children with DSD and associated CUGS symptoms.<s...

hrp0095p1-448 | Diabetes and Insulin | ESPE2022

The effect of physical activity on leptin and adiponectin in youth with T1D

Kaza Maria , Tsentidis Charalambos , Vlachopadopoulou Elpis , Sakou Ikboule , Paltoglou George , Mastorakos George , Karavanaki Kyriaki

Introduction: Exercise has pleiotropic positive effects for children and adolescents with Type 1 Diabetes (T1D). It improves glycemic control, daily insulin requirements, quality-of-life, morbidity and mortality rate. Leptin and adiponectin are adipocytokines produced by adipose tissue cells. Adiponectin is anti-atherogenic, anti-diabetic and anti-inflammatory, whereas leptin induces insulin resistance, has thermoregulatory properties and is pro-inflammatory.<...

hrp0092p1-169 | Bone, Growth Plate and Mineral Metabolism (1) | ESPE2019

Hypercalcemia as a Post Stem Cell Transplantation Complication in Children with Osteopetrosis - A Single Centre Experience

Paul Praveen George , N.A Fouzia , Korula Sophy , Mathai Sarah , George Biju , Simon Anna

Introduction: Osteopetrosis (OP) is a rare genetic disorder that is characterized by abnormal osteoclast function resulting in dense bones and marrow failure. The only definitive cure for OP is stem cell transplantation (SCT). Hypercalcemia is a well described complication in children with OP undergoing SCT. This study describes the calcium profile and treatment modalities used to maintain normocalcemia in children with OP undergoing SCT.<p class="abstext"...

hrp0089rfc9.4 | Pituitary, Neuroendocrinology and Puberty 1 | ESPE2018

REplacement of MAle mini-Puberty in Neonates and Children with Micropenis and Cryptorchidism due to Hypogonadotropic Hypogonadism: Results of the ‘REMAP’ Study ISRCTN13007297

Papadimitriou Dimitrios T , Chrysis Dionysios , Nyktari Georgia , Zoupanos George , Liakou Eleni , Papadimitriou Anastasios , Mastorakos George

Background: Hormonal replacement in boys with congenital Hypogonadotrophic Hypogonadism (HH) as well as hormonal repair of bilateral cryptorchidism and micropenis remain a challenge in pediatric endocrinology.Methods: In the «REMAP» study ISRCTN13007297 eight neonates and infants, all with bilateral cryptorchidism in intra-abdominal position and micropenis (≤2 cm), with absence of neonatal male-mini puberty were treated for 3 months with ...

hrp0089p1-p203 | Pituitary, Neuroendocrinology and Puberty P1 | ESPE2018

Serum Concentrations of the Endocrine Disruptors-organochlorine Pesticides (OCPs) in Greek Children with Neurodevelopmental Disorders

Makris Gerasimos , Chrousos George , Sabico Shaun , Abd-Alrahman Sherif , Al-Daghri Nasser , Chouliaras George , Pervanidou Panagiota

Background: The exposure to environmental toxicants has been estimated to contribute directly to 3% of human neurodevelopmental disabilities (NDDs). Organochlorine pesticides (OCPs), which are widespread persistent organic pollutants, have been implicated mainly because of their endocrine disruptive nature. Several studies have reported the above relations between maternal serum, the placenta barrier and the breast milk levels of OCPs and NDDs.Aim: The a...

hrp0086rfc13.2 | Management of Obesity | ESPE2016

The Use of Proteomics in the Assessment of Health Status of Offspring Born after Intracytoplasmic Sperm Injection (ICSI)

Kosteria Ioanna , Gkourogianni Alexandra , Papadopoulou Aggeliki , Anagnostopoulos Athanasios , Chrousos George , Tsagaris George , Kanaka-Gantenbein Christina

Background: Several studies have correlated Assisted Reproduction Technologies (ART) including classic IVF and Intacytoplasmic Sperm Injection (ICSI) with epigenetic alterations in the offspring that could have long lasting unfavorable metabolic effects. Proteomics, a state-of-the-art technology used for the identification of early biomarkers of disease, has already been implemented in the search of success in ART but not yet for such markers evaluation in offspring of ART.</p...

hrp0082fc12.2 | Obesity | ESPE2014

Obesity in Childhood and Adolescence is Associated with Shorter Leucocyte Telomere Length

Lamprokostopoulou Agaristi , Moschonis George , Manios Yannis , Chrousos George P , Charmandari Evangelia

Background: Obesity in adulthood is associated with shorter leukocyte telomere length, a marker of biological age that is also associated with age-related disorders, including cardiovascular disease and type 2 diabetes mellitus.Objective and Hypotheses: To investigate the relation between BMI in childhood and adolescence and telomere length, by determining the mean telomere length of leukocytes.Patients and Method: Seven hundred fo...

hrp0084p2-427 | GH &amp; IGF | ESPE2015

rhGH Replacement Therapy Ameliorates Body Composition Substantially but has No Effect in the Quality of Life in Adolescents with GH deficiency – A Cross-Sectional Study

Stefanaki Charikleia , Paltoglou George , Bacopoulou Flora , Boschiero Dario , Chrousos George P

Background: GH is fundamental in skeletal growth during puberty, however detailed studies of body composition analyses in adolescents with GH deficiency on GH therapy are scarce. Moreover, there are few studies on the psychologic aspects of hrGH therapy in this population.Objective and hypotheses: In this case-control study, we investigated differences in body composition based on bio-impedance measurements between adolescents with idiopathic GH deficien...