hrp0092p2-183 | Growth and Syndromes (to include Turner Syndrome) | ESPE2019

The Prevalence of Celiac Disease (CD) in Children with Type 1 Diabetes Mellitus (T1D); Does CD Adversely Affect Linear Growth in these Children?

Alyafei Fawzia , Soliman Ashraf , Sabt Aml , Elsayed Nagwa

The prevalence of biopsy-proven CD in T1D in pediatric populations widely ranges between 2.6 in Finland to 16.4 in Algeria. Many patients with CD and T1D are either asymptomatic (silent CD) or present with only mild symptoms. CD children may be less likely to show overt growth failure but can have weight and height measures at a lower growth percentile and complain of nonspecific symptoms, including anorexia and lassitude.Aim; Patients and Methods:<p...

hrp0089p3-p087 | Diabetes &amp; Insulin P3 | ESPE2018

Prevalance of Fatty Liver in Patients with Type 1 Diabetes Mellitus Attending Diabetes Clinic at Alexandria University Children’s Hospital

Fawzy Dina , Elsayed Shaymaa , Adel Abdel-Moneim Mahmoud

Background: Type 1 diabetes mellitus (T1DM) - related hepatopathy is not uncommon and tends to be more prevalent among children with poor glycemic control. Recent studies suggest that fatty liver disease may be more common in T1DM than previously thought.Aim: The aim of this work was to determine the frequency of hepatopathy in patients with type 1 diabetes mellitus attended diabetes clinic at Alexandria university children’s hospital (AUCH) and it&...

hrp0089p3-p417 | Diabetes &amp; Insulin P3 | ESPE2018

Study of Children with Type 1 Diabetes Mellitus of Long Duration Attending Alexandria University Children’S Hospital

Fawzy Dina , Elsayed Shaymaa , Abd El-Moneim Mahmoud

Background: Type 1 diabetes mellitus (T1DM) is a complex metabolic disorder typically diagnosed in childhood and characterized by insufficient insulin production. Diabetic complications are still a major concern as they constitute the main cause of morbidity and mortality in diabetic patients despite the advances in T1DM treatment. Long-term complications of diabetes include retinopathy with potential loss of vision; nephropathy leading to renal failure; peripheral neuropathy ...

hrp0094p2-395 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

Cognitive function and linear growth in Prednisone-treated children with salt-wasting congenital adrenal hyperplasia

Elsayed Shaymaa , Soliman Ashraf , Omar Tarek , Ibrahim Sandra , Elawwa Ahmed ,

Introduction: Congenital adrenal hyperplasia (CAH) is a disorder with a wide spectrum of severity. Impaired cognition has been reported in patients with CAH, although the findings have been conflicting. It has been hypothesized that the major causes of the deficits are prenatal hormonal imbalances and/or excessive glucocorticoid treatment.Objective: The objective of this study was to investigate cognitive function in chi...

hrp0094p2-202 | Fat, metabolism and obesity | ESPE2021

The challenges faced in the management of Congenital Generalized Lipodystrophy.

Abdelmeguid Yasmine , Elashry Reham , Elsayed Shaymaa , Raafat Shaymaa ,

Background: Congenital Generalized Lipodystrophy (CGL) is a rare autosomal recessive disease. The prevalence has been reported to be 1 in 10million with around 500 cases worldwide. The absence of functional adipocytes results in storage of lipids in other tissues, including muscle & liver. The diagnosis of CGL is based on clinical data; however, there is phenotypic heterogeneity. Metreleptin injections cause decreased appetite & is beneficial in loweri...

hrp0092p2-50 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

Bone Mineral Density in Children with Type 1 Diabetes Mellitus (T1DM) and Analysis of Possible Factors Affecting Their Bone Health; A controlled study

Abdel Meguid Ahmed Shaymaa Elsayed , Saleh Elsayed Salma Mohamed , Hazem Gouda Mohamed , Mokhtar Emara Doaa , Elawwa Ahmed , Soliman Ashraf

Type 1 diabetes mellitus (T1DM) may be associated with reduced bone mineral density (BMD). Possible pathogenic mechanisms include impaired bone anabolic effect due to decreased insulin and insulin-like growth factor 1 (IGF-I). In addition, hyperglycemia can impair osteoblast function.We measured anthropometric data, glycemic control (HbA1C), insulin dose /kg, calcium, PO4 and alkaline phosphatase and BMD by (DEXA scan at the spine (L2–L4) and at the...

hrp0092p2-33 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

Growth and Bone Mineral Density in Egyptian Children with Congenital Adrenal Hyperplasia on Glucocorticoid Replacement Therapy; A Single Center Study

Magdy Omar Omneya , Elsayed Shaymaa , Abokhashaba Mohamed , Abd El Fattah Magdy

Background: Children with congenital adrenal hyperplasia (CAH) need chronic glucocorticoid therapy, both to replace congenital deficit in cortisol synthesis and to suppress the overproduction of androgens by the adrenal cortex. High doses of glucocorticoid taken chronically might affect bone metabolism and lead to alterations of bone mass in this condition. In particular, they could increase bone resorption rate. Bone mineral density (BMD) by energy X-ray abso...

hrp0092p2-258 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Study of Autistic Features Among Children and Adolescents with Congenital Adrenal Hyperplasia

Elsayed Shaymaa , Omar Tarek , El Bardeny Magdy , El-Latif Soha Abd , Ibrahim Sandra

Introduction: Autism spectrum disorder (ASD) consists of a pattern of persistent deficits in social communication and interaction across multiple contexts together with restricted, repetitive patterns of behavior, interests or activities. In the general population autistic traits can be found more frequently in males than females. This male predominance indicates that high androgen levels may prenatally have influence on development of autistic traits.<p c...

hrp0089p2-p015 | Adrenals and HPA Axis P2 | ESPE2018

Study of Cardiovascular Risk Factors and Carotid Intima-Media Thickness in Children with Congenital Adrenal Hyperplasia

Elsayed Shaymaa , Emam Mohamed , El Fattah Magdy Abd , Gabal Ahmed Abou

Introduction: Congenital Adrenal Hyperplasia (CAH) is the commonest cause of Disorder of Sex development (DSD). It is a group of autosomal recessive disorders caused by deficiency of enzymes involved in synthesis of cortisol, aldosterone or both. The combination of hypocortisolism, hyperandrogenism and adrenal medullary hypofunction due to the disease and side effects of steroids treatment may make these individuals more prone to develop cardiovascular disorders including impa...

hrp0089p2-p375 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P2 | ESPE2018

Could Basal AMH Replace hCG Stimulation Test in XY Disorder of Sex Development Cases

Elsayed Shaymaa Raafat , Abdo Magdy Omar , Badawy Haytham Elmetwaly , Abbassy Hadeer Aly , Yaseen Duaa Khatter

Background: Traditionally, the standard endocrinological evaluation of 46, XY DSD cases is based upon measurement of testosterone, dihydrotestosterone and androstenedione and their ratios either in mini-puberty or under human chorionic gonadotropin (hCG) stimulation. However, this method is of limited value in reaching definite diagnosis in many cases. More recently, there is a growing appreciation of the value of assessing Sertoli cell function because the most active compart...