ESPE Abstracts

Background: There are multiple indications where evaluation of the Hypothalamic-pituitary-adrenal (HPA) axis in neonates may be considered e.g. hypoglycaemia, hypotension, conjugated hyperbilirubinemia; however permanent neonatal adrenal insufficiency (AI) is rare. Interpretation of results can be challenging due to a paucity of normative reference data in this population. This risks overdiagnosis and unnecessary treatment with corticosteroids leading to the a...

Background: Diabetic nephropathy (DN) is the leading contributor to high morbidity and mortality in patients with type 1 Diabetes (T1D). Abuminuria, the gold standard marker of renal damage in diabetic nephropathy, lacks the sensitivity to detect the earliest changes in renal function; as renal histopathological changes were reported to be found before the onset of albuminuriaAim of the work: To assess the diagnostic rol...

Background: The global prevalence of childhood and adolescent obesity has surged since 1980, reaching 107.7 million cases in 2015. Notably, 23% of children in developed countries are overweight or obese. The Atherogenic Index of Plasma (AIP) emerges as a novel, robust biomarker, closely linked to obesity, and serves as a reliable indicator of dyslipidemia and associated conditions, including cardiovascular diseases.Aim: ...

Background: Small for Gestational Age (SGA) infants, characterized by a birth weight below the 10th percentile for their gestational age, are susceptible to growth challenges. This longitudinal study investigates the postnatal growth of 10 SGA infants with birth weights under 1.5 kg, tracking their Weight-for-Age Z-score (WAZ), Length-for-Age Z-score (LAZ), and Weight-for-Length Z-score (WLZ) for five years.Methods: This...

Background: Growth monitoring of Appropriate for Gestational Age (AGA) preterm infants is critical for the assessment of postnatal developmental progress and health outcomes. This study aims to delineate the postnatal growth patterns of AGA preterm infants with birth weights less than 1.5 kilograms, using Z-scores for length-for-age (LAZ), weight-for-age (WAZ), weight-for-length (WLZ), and head circumference-for-age (HCZ) over the first 60 months of life.<...

Background: The growth and development of human tissues are critically regulated by the Insulin-like Growth Factor 1 Receptor (IGF1R) and its ligand IGF-1. Mutations in the IGF1R gene and less frequently in the IGF1 gene are associated with a heterogeneous group of growth disorders, manifesting as intrauterine and postnatal growth retardation.Literature Review: In this review, a total of 47 papers were analyzed, providin...

Background: The growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis is central to growth and metabolism. Growth hormone deficiency (GHD) in children can lead to metabolic disturbances and an increased risk of hypoglycemia. However, the response of blood glucose levels to glucagon in the presence of GHD compared to children with idiopathic short stature (ISS) is not well understood. This study aims to elucidate the glucose response to glucagon in thes...

Introduction: Growth Hormone Deficiency (GHD) in early childhood is a significant concern due to its impact on physical development. This retrospective study investigates the early growth patterns of children diagnosed with GHD during early childhood (average diagnosis age 5.2 years &pm; 1.1 years) to understand the progression of growth deviations in this population.Patients and Methods: Our study involved a retrospecti...

Introduction: The PAPPA2 gene plays a crucial role in growth regulation through its interaction with the insulin-like growth factor (IGF) system. Mutations in this gene can lead to disrupted growth patterns. This case report describes the clinical course of a Yemeni girl with a pathogenic PAPPA2 variant, characterized by high IGF-1 levels and affected linear growth and weight gain.Case Presentation: A 5-year-old girl of ...

Background: Understanding the growth trajectories of preterm Appropriate for Gestational Age (AGA) infants with birth weights under 1.5 kg is crucial for optimizing their long-term health outcomes. This study explores the correlations between various growth parameters over five years to identify predictive markers for future growth.Methods: A longitudinal cohort study was conducted on preterm AGA infants (n = 50...