hrp0097p1-436 | Diabetes and Insulin | ESPE2023

Should the diagnostic criteria of childhood obesity depend on the nutritional status of national pediatric population? A lesson form assessment of Ukrainian children with type 1 diabetes in Poland after Russian aggression against Ukraine.

Smyczyńska Joanna , Suchowiński Michał , Kopeć Kacper , Seliga Przemysław , Olejniczak Aleksandra , Szadkowska Agnieszka

Introduction: Childhood overnutrition is a global challenge of public health. Both WHO and different countries have prepared BMI charts for pediatric population. Proper assessment of nutritional status is particularly important in children with type 1 diabetes (DM1). Due to Russian aggression, some Ukrainians with DM1 have to continue treatment in Poland.Aim: to compare HbA1 concentrations and the incidence of overnutrit...

hrp0097p1-197 | Thyroid | ESPE2023

Effects of methimazole therapy on effector T and B regulatory cells in pediatric patients with Graves' disease

Stożek Karolina , Grubczak Kamil , Starosz Aleksandra , Bossowski Filip , Moniuszko Marcin , Bossowski Artur

Introduction: The incidence of autoimmune thyroid diseases (ATD) is constantly rising. Graves’ disease (GD) remains the most common cause of thyrotoxicosis in pediatric population, but the exact pathogenesis of GD is still not fully understood. The immunological basis of ATD assumes an imbalance between effector and regulatory T lymphocytes. B regulatory cells (Breg) are able to suppress the pro-inflammatory properties of effector T cells. Methimazole (M...

hrp0097p2-125 | Bone, Growth Plate and Mineral Metabolism | ESPE2023

Unusual presentation of polyostotic fibrous dysplasia in two unrelated patients

Sukarova-Angelovska Elena , Tesovnik Tine , Krstevska-Konstantinova Marina , Janchevska Aleksandra , Daniloski Darko

Background: Fibrous dysplasia (FD) is rare disease that affects skeletal system characterized mostly by abnormal bone formation. The newly formed disorganized mass includes fibrous tissue with poorly organized immature trabeculae. FD is a highly incapacitating condition where fractures, deformities and consecutive functional impairment could occur as mono, olygo or polyostotic form. Aside from predominantly asymmetric skeletal involvement, extra-skeletal manif...

hrp0097p2-104 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2023

Gender dysphoria, social transition, mental health and metabolites of cortisol among transgender and gender non-conforming youth in one of Polish hospitals.

Jakubowski Tomasz , Gawlik Aneta , Antosz Aleksandra , Chmiel-Aleksandrowicz Iga , Gawlik Jakub , Nowak Zuzanna

Introduction: In the body of available literature, the information on the relationship between the level of gender dysphoria (GD), social transition and mental health and hormone levels is scant.Methods: The data has been obtained from medical records of 120 transgender and gender non-conforming (TG/GNC) young patients of the pediatric and endocrinological ward of the Upper Silesian Center of Youth’s Health in Kato...

hrp0098fc3.3 | Pituitary, Neuroendocrinology and Puberty 1 | ESPE2024

Analysis of clinical factors affecting retinal ganglion cell complex thickness reduction in patients with childhood onset craniopharyngioma.

Bogusz-Wójcik Agnieszka , Rakusiewicz Klaudia , Tutka Aleksandra , Hautz Wojciech , Jaworski Maciej , Moszczyńska Elżbieta

Background: Visual impairment is a critical component of aftercare in survivors of childhood onset craniopharyngioma (CP). This study aims to evaluate retinal ganglion cell complex thickness (GCC) and correlation with clinical parameters in patients with CP using optical coherence tomography (OCT).Methods: Sixty eyes of 37 patients with childhood onset craniopharyngioma and 90 eyes of 45 age and sex-matched healthy volun...

hrp0098p1-188 | Pituitary, Neuroendocrinology and Puberty 3 | ESPE2024

Childhood-onset craniopharyngioma: 26 years of experience at Children's Memorial Health Institute (CMHI)

Moszczyńska Elżbieta , Bogusz-Wójcik Agnieszka , Tutka Aleksandra , Baszyńska-Wilk Marta

Introduction: Childhood onset craniopharyngioma (CP) is a rare, low-grade (WHO I) embryonic malformation arising from remnants of the craniopharyngeal duct in the sellar and parasellar regions.Methods: This retrospective study included 167 children (53% boys, 47% girls) diagnosed with CP at the CMHI, Warsaw, Poland, from 1998 to 2024. We evaluated anthropometric data, hormonal test results pre- and post-surgery, brain ma...

hrp0098p1-284 | Sex Endocrinology and Gonads 3 | ESPE2024

Face processing patterns in individuals with gender incongruence or differences of sex development: an eye-tracking study.

Kolesinska Zofia , Kupinski Szymon , Zakrzewska Marzena , Biadala Magdalena , Kapczuk Karina , Niedziela Marek , Chodecka Aleksandra

Background: Face processing is considered the most highly developed visual perception ability, with research indicating differences between genders. Gender incongruence (GI) refers to person’s experience of an incompatibility between gender identity and birth-assigned sex. Differences of sex development (DSD) encompass rare congenital conditions, in which chromosomal, gonadal or phenotypic development is atypical. The study aimed to investigate face proc...

hrp0098p2-194 | Growth and Syndromes | ESPE2024

Effectiveness of therapy with recombinant human growth hormone (rhGH) in patients with HLHS and short stature

Wędrychowicz Andrzej , Furtak Aleksandra , Ossowska Magdalena , Komorkiewicz Karolina , Roztoczynska Dorota , B. Starzyk Jerzy

Hypoplastic left heart syndrome (HLHS) is one of the most severe congenital heart defects. Despite medical progress, HLHS patients remain at risk of many complications of this cardiac defect and cardiac surgery, including growth failure. Some of them can be treated with recombinant human growth hormone (rhGH) fulfilling criteria of GH–deficiency (GHD) or having a history of intrauterine growth restriction or small for gestational age (SGA). We assessed the effectiveness ...

hrp0098p3-210 | Pituitary, Neuroendocrinology and Puberty | ESPE2024

Hypergonadotropic hypogonadism in a girl after bone marrow transplantation from a male unrelated donor.

Shuperliska Elizabeta , Shukarova-Angelovska Elena , Krstevska-Kostantinova Marina , Jancevska Aleksandra , Ivanova Daniela

Background: Primary hypogonadism in females is characterized by inadequate ovarian function, resulting in insufficient or absent production of estrogens. This case report aims to present a rare case of primary amenorrhea in a female child where bone marrow transplantation (BMT) was performed due to the beta-thalassemia.Case presentation: A 14-year-old girl approached the endocrinology department for evaluation due to del...

hrp0098p3-253 | Thyroid | ESPE2024

Growth hormone deficiency in patients with late detected Hashimoto thyroiditis-how long to wait for treatment

Sukarova-Angelovska Elena , Shuperliska Elizabeta , Krstevska-Konstantinova Marina , Janchevska Aleksandra , Sapundjija-Karadjoska Felina

Background: Chronic autoimmune thyroiditis (AT) is a leading cause for acquired primary hypothyroidism in children. The prevalence of the AT in pediatric age is lower than in adults - approximately 2%. Familial predisposition is well established, however exact pathophysiologic mechanism is still not known. Since the first signs of Hashimoto thyroiditis are nonspecific and challenging to recognize, also the disease is not associated with pediatric age, the diag...