hrp0095wg4.1 | ESPE Working Group on Diabetes Technology (DT) Symposium | ESPE2022

Use of Automated Insulin Delivery systems (AIDs) in preschool children

de Beaufort Carine

Management of type 1 diabetes in preschool children is a huge challenge for their caregivers. Age-specific factors (e.g. unpredictable food intake and physical activity, small insulin doses, high insulin sensitivity, frequent intercurrent infections, high variability in insulin requirements) increase the complexity of daily diabetes management. Furthermore, the preschool child depends completely on his/her caregiver. To meet recommended treatment targets while avoiding hypogly...

hrp0084p2-537 | Puberty | ESPE2015

Increased Ambulatory Blood Pressure in Adolescents with Gender Dysphoria Treated with Gonadotropin- Releasing Hormone Analogues

Klink Daniel , Bokenkamp Arend , Atsma Eline , Rotteveel Joost

Background: Adolescents with gender dysphoria (GD) are treated with gonadotropin-releasing hormone analogues (GnRHa) to prevent the development of characteristics of the undesired sex. Subsequently, sex steroids of the desired sex, cross sex hormones (CSH) are added. GnRHa treatment is generally considered to be safe in the treatment of precocious puberty in children. However, we observed that some adolescents with GD developed hypertension during GnRHa monotherapy (Klink D <e...

hrp0094p1-168 | Growth B | ESPE2021

Mother’s smoking during pregnancy influence intrauterine and postnatal growth - the GrowUp 1990 Gothenburg cohort population

Holmgren Anton , Niklasson Aimon , Aronson A. Stefan , Albertsson-Wikland Kerstin ,

Background/Objective: Smoking during pregnancy is known to influence prenatal/postnatal growth of the offspring. We investigated the impact of smoking in the Swedish reference population for new reference for height, weight and BMI, the GrowUp1990Gothenburg cohort.Material/Methods: The study was based on 1907 healthy children (918girls/989boys) born at term in Sweden with Nordic parents and longitudinal growth measurements. 155girls/180b...

hrp0094p2-241 | Fetal, neonatal endocrinology and metabolism (to include hypoglycaemia) | ESPE2021

Incidence of early neonatal hypoglycemia and some related risk factors in Qatar. A cohort study over two years (2018 and 2019)

Soliman Ashraf , Ali Hamdy , Alaaraj Nada , Alyafei Fawzia , Hamed Noor , Ahmed Shaymaa ,

Objective: The objective of this study is to determine the incidence of early neonatal hypoglycemia and to confirm potential risk factors.Study design: The study was conducted at a tertiary Medical Center in Qatar. between January 2018 and December 2019. First blood glucose concentrations of all infants admitted to the nursery were measured using a "point of care" analyzer (Accu-Chek). We recorded risk factors for hypoglycemia su...

hrp0098p3-321 | Late Breaking | ESPE2024

Etiological aspects of growth failure

Benyahya Nadia , Rhouzali Khawla , Hamdane Chaymae , Bouichrat Nisrine , Rouf Siham , Latrech Hanane

Introduction: Short stature is a common cause of consultation in the endocrinology department, It can be a sign of many affections or hereditary conditions. A clear and rapid diagnostic procedure is imperative for the improvement of height prognosis. The present study sought to evaluate the etiological profile of short stature in childrenPatients and Methods: This is a retrospective study of 292 patients admitted for del...

hrp0092p3-273 | Late Breaking Abstracts | ESPE2019

Insulin Sensitivity as Homa at Start and End of HGH Treatment of Children with Congenital (C) Ighd and Mphd

Laron Zvi , Shmalia Mona , Kauli Rivka , Lilos Pnina

Background: Patients with congenital IGHD or MPHD develop adiposity already "in utero". The effects of growth hormone (GH) treatment on adipose tissue are controversial, many claiming that GH reduces body fat (1.2). In addition there are reports that long-term GH treatment causes glucose intolerance, insulin resistance, followed in some instances by diabetes (3).Objective: To determine whether long-term hGH treat...

hrp0089fc14.3 | Multisystem Endocrine Disorders | ESPE2018

Regulation of Salt, Sugar and Sex Steroids in Humans by Genetic Variations in NADPH Cytochrome P450 Oxidoreductase (POR) Identified in 1000 Genome Samples

Pandey Av Amit V , Udhane Sameer S , Parween Shaheena

A broad spectrum of human diseases, including abnormalities in steroidogenesis, are caused by mutations in the NADPH cytochrome P450 oxidoreductase (POR) (1-4). Human POR is a diflavin reductase that transfers electrons from NADPH to small molecules, non-P450 redox partners and cytochrome P450 proteins in the endoplasmic reticulum. Cytochrome P450 proteins perform a very wide range of reactions, including metabolism of steroids, drugs and other xenobiotics. Therefore, genetic ...

hrp0089p2-p360 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P2 | ESPE2018

Spontaneous Pregnancies in Female Survivors of Childhood Hematological Malignancies Post Allogeneic Haemopoietic Stem Cell Transplantation

Lai-Ka Lee Samantha , Zacharin Margaret , Tiedemann Karin

Background: With improved treatment and survival of childhood hematological malignancies, the issue of fertility in survivors has become an important domain of holistic care. Haemopoietic stem cell transplant (HSCT) survivors were reported to have reduced fertility as compared to siblings, with 4/170 adult female allogeneic HSCT survivors achieving successful pregnancy.1 Of 532 female survivors, median age of 17.8 years at HSCT, who had TBI conditioning, 13 pregnanc...

hrp0086rfc14.4 | Growth : Mechanisms | ESPE2016

Genetic Diagnosis of Congenital Growth Hormone Deficiency by Massive Parallel Sequencing Using a Target Gene Panel

Nakaguma Marilena , de Lima Jorge Alexander Augusto , de Assis Funari Mariana Ferreira , Lerario Antonio Marcondes , de Azevedo Correa Fernanda , de Carvalho Luciani Renata Silveira , de Mendonca Berenice Bilharinho , Arnhold Ivo Jorge Prado

Background: Congenital GH deficiency (GHD) can be isolated (IGHD) or combined with other pituitary hormone deficiencies (CPHD). The identification of mutations has clinical implications for the management of patients and genetic counseling1.Objective: To prospectively conduct a molecular-genetic analysis in genes associated with IGHD or CPHD.Method: Forty patients with IGHD (n=8) or CPHD (n=32) were stu...

hrp0084p3-774 | Diabetes | ESPE2015

Is Autoimmunity on the Increase in Type 1 Diabetes Mellitus? Presentation of Multiple Auto-Immune Disorders at Diagnosis of Type 1 Diabetes Mellitus

Elangaratnam Diluxshy , Punniyakodi Sadhanandham , Puthi Vijith

Background: Globally approximately 8%1 of children have type 1 diabetes mellitus (TIDM) with an incidence of 24.5 in every 100 000 children (0–14 years)2. TIDM is an autoimmune condition causing the destruction of beta islet cells and is associated with other autoimmune conditions such as coeliac disease (10% of children with TIDM test are positive for TTG) and hypothyroidism (25% have thyroid autoantibodies). We would like to report a case series of...