hrp0095p1-366 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Hemorrhagic pituitary apoplexy due to pituitary adenoma: description of two cases in two adolescent males

Ciccone Sara , Vestrucci Benedetta , Lia Cataldi Maria , Balestrieri Antonio , Ruggiero Maria , Grandone Anna

Context: Pituitary apoplexy is rare endocrine emergency, resulting from ischemia and/or hemorrhage and necrosis of a pituitary tumor (typically an adenoma). Children and adolescents show severe headache sometimes associated with cranial neuropathies from compression of the optic chiasm or the cavernous sinus.Case presentation: A 15-year-old boy was admitted with severe headache and vomiting since 3 days, without visual d...

hrp0095p2-274 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

Congenital hypogonadotropic hypogonadism caused by a novel mutation of GnRHR gene: a case report

Cristina Maggio Maria , Venezia Renato , Maria Di Blasio Anna , Corsello Giovanni

Hypogonadotropic hypogonadism is characterized by low levels of gonadotropins and delayed or absent sexual development. Most of the patients reach the diagnosis in late adolescence or in adulthood. A timely, appropriate diagnosis implicates a better clinical outcome and treatment timing. We describe the clinical case of a 15-year-old girl with primary amenorrhea. Stature and weight were in accordance with mid parental height; Tanner stage: PH2 B1. FSH, LH, oestradiol showed pr...

hrp0092p1-69 | Fetal, Neonatal Endocrinology and Metabolism (to include Hypoglycaemia) | ESPE2019

Molecular Mechanisms of Idiopathic Ketotic Hypoglycemia in Children

Ivannikova Tatiana , Milovanova Natalya , Zakharova Ekaterina , Gubayeva Dilyara , Kareva Maria , Melikyan Maria

Idiopathic Ketotic Hypoglycemia (IKH) is the most common non-iatrogenic cause of hypoglycemia in children beyond infancy. The severity of the symptoms and frequency of hypoglycemic episodes may vary among the patients. The etiology of IKH is unclear; disturbances in gluconeogenesis, glycolysis and glycogenolysis were regarded as possible causes. Familial IKH recurrence is often observed, suggesting a genetic basis of glucose homeostasis dysregulation.We ...

hrp0092p2-214 | Multisystem Endocrine Disorders | ESPE2019

Celiac Disease and Endocrine Autoimmunity in Children and Adolescents

Mitrogiorgou Marina , Karachaliou Feneli , Karalexi Maria , Georgantzi Maria , Kontaki Helen , Foukas Periklis , Triantafyllou Konstantinos , Fesssatou Smaragdi

Objectives: Celiac disease (CD) is a life-long inflammatory disease of the gastrointestinal tract that affects genetically susceptible individuals and is associated with several autoimmune diseases. The aim of the study was to evaluate the prevalence of coexistent autoimmune endocrine disorders in children and adolescents diagnosed with CD.Patients and Methods: Children diagnosed with CD in the Paediatric Gastroenterolog...

hrp0089p2-p090 | Diabetes & Insulin P2 | ESPE2018

An Unusual Case of an Exclusively Vegan Child with Diabetic Acidosis

Xatzipsalti Maria , Konstantakopoulos Sotiris , Kourti Afroditi , Anastasoudi Maria , Fafoula Olga , Limperatou Christina , Stamogiannou Lela , Vazeou Andriani

Case presentation: A 17 month old female child was transferred to our hospital from another hospital where she was admitted to the intensive care unit (ICU) due to cerebral edema, diabetic acidosis and severe dehydration. The patient had fever, polyuria, polydipsia and vomiting presented four days before admission. At her admission she was unconscious with dilated pupils, no reaction to painful stimuli (GCS 4/15) and Kussmaul breathing. Her initial blood glucose level was 391 ...

hrp0089p2-p112 | Diabetes & Insulin P2 | ESPE2018

A Rare Case of Diabetes Mellitus Type 1 in a Child with Neurofibromatosis Type 1

Panoutsou Eleni , Oikonomakou Maria-Zoi , Vallianatou Markella , Koufoglou Eleni , Giannopoulou Sotiria , Eliopoulou Maria

Introduction: Neurofibromatosis type 1 (NF1) is an autosomal dominant multisystemic neurocutaneous disorder characterized by an increased risk of benign and malignant tumor formation (neurofibromas, glioma and gastrointestinal stromal tumor). The incidence has been described to be around 1 in 2,500–3,500 live births, and the estimated prevalence is 1 in 4,000–5,000. Although it was first described by von Recklinghausen in 1882, the formal diagnostic criteria were pub...

hrp0089p3-p209 | GH & IGFs P3 | ESPE2018

Vitamin D Status in Children with Isolated Idiopathic GH Deficiency (GHD) in North and Central Greece

Tsiroukidou Kyriaki , Xatzipsalti Maria , Mameka Iliana , Polychroni Ioulia , Vamvakis Anastasios , Papagianni Maria , Stamogiannou Lela

Background: Vitamin D status in children with isolated GHD has been analyzed in few studies with controversial results. The aim of the study was to assess vitamin D status in children with idiopathic GHD in North and Central Greece.Materials and methods: 128 children (M/F: 76/61, mean age 9.5 (S.D.±3.5 years) with isolated GHD were compared with 65 controls (M/F: 46/3, mean age 9.3 (S.D.±3.2 years). Children were d...

hrp0089p2-p408 | Thyroid P2 | ESPE2018

The Congenital Hypothyroidism Screening Programme in a Sigle Italian Centre: a 5-Years Retrospective Study

Maggio Maria Cristina , Ragusa Saveria Sabrina , Aronica Tommaso Silvano , Granata Orazia Maria , Gucciardino Eleonora , Corsello Giovanni

Congenital hypothyroidism (CH) occurs in approximately 1:2000–1:3000 newborns in Italy. Lowering of the TSH cut-off was the most important factor contributing to the increase of CH incidence in Italy. The aim of this study is the determination of the prevalence of CH in northwest Sicily, evaluated by the single screening centre of the Children Hospital ‘G. Di Cristina’, ARNAS, Palermo. From January 2013 to December 2017, 79.699 newborns were screened testing TSH...

hrp0086p2-p317 | Diabetes P2 | ESPE2016

Type 1 Diabetes in Childhood: An 8-year Experience

Vaggopoulou Chari , Oikonomakou Maria-Zoi , Katsikareli Evanthia , Vallianatou Markella , Krokidas Georgos , Iliopoulou Maria

Background: Type 1 diabetes mellitus (DMI) is a chronic disease that requires frequent visits in outpatient pediatric endocrine clinics in order to rearrange their new lives.Objective and hypotheses: A retrospective study of patients with DMI was performed during 2008–2015, assessing epidemiological and clinical data, treatment and subsequent course.Method: We analyzed the incidence, age and gender of 75 patients at the diseas...

hrp0086p1-p617 | Growth P1 | ESPE2016

The Blood Antioxidant System in Adult Growth Hormone Deficient Patients after Concluded Childhood Growth Hormone Therapy

Vorontsova Maria , Pankratova Maria , Yusipovich Alexander , Adil Baizhumanov , Shiryaeva Tatyana , Nagaeva Elena , Georgiy Maximov , Peterkova Valentina

Background: The antioxidant system that protects tissues from damaging oxidation processes is a universal indicator for metabolic balance. It is known that GH deficiency (GHD) is associated with a high risk of developing metabolic disorders.Objective and hypotheses: The aim of this study was to examine the effects of inadequate GH secretion on the markers of the blood antioxidant system in adult GHD patients.Method: The study inclu...