hrp0097rfc4.3 | Growth and syndromes (to include Turner syndrome) | ESPE2023

Aromatase inhibitors: an effective and safe option for height increment in boys with growth hormone deficiency?

Kağızmanlı Gözde Akın , Özalp Kızılay Deniz , Besci Özge , Yüksek Acinikli Kübra , Özen Samim , Demir Korcan , Damla Gökşen Şimşek Ruhsar , Böber Ece , Darcan Şükran , Abacı Ayhan

Background: Aromatase inhibitors (AIs) have been suggested to slow down estrogen-dependent skeletal maturation in pubertal boys with short stature. In the literature, few studies evaluate the efficacy and safety of AIs in boys with growth hormone deficiency (GHD). Objective: To evaluate the auxologic effects and short-term laboratory profiles of combined AI and rhGH therapy in adolescent males with GHD.Subjects and Methods:</stro...

hrp0095p1-198 | Thyroid | ESPE2022

FT3:FT4 ratio be used to predict relapse and remission? Single Centre Experience

Kara Leyla , Çiçek Dilek , Sarıkaya Emre , Gök Ebru , Berber Uğur , Gül Şiraz Ülkü , Kurtoğlu Selim , Kendirci Mustafa , Hatipoğlu Nihal

Introduction: Graves’ Disease (GD) is autoimmune hyperthyroidism occurring mostly in adolescent girls. The main pathogenic role of the disease is attributed to TSH receptor antibodies (TRAb), which stimulate the thyroid gland to increase the production of the most active thyroid hormone- triiodothyronine (T3). High levels of TRAb and a large goitre size are commonly known as poor prognostic factors for the disease and are used to predict relapse.<p c...

hrp0095p1-600 | Thyroid | ESPE2022

Response to Growth Hormone Therapy in Turner And Noonan Syndrome: First Year And Final Height

Kara Leyla , Çiçek Dilek , Sarıkaya Emre , Gök Ebru , Berber Uğur , Gül Şiraz Ülkü , Kurtoğlu Selim , Kendirci Mustafa , Hatipoğlu Nihal

Background: Despite different genetic backgrounds, Noonan syndrome (NS) shares similar phenotype features to Turner syndromes (TS) such as short stature, webbed neck and congenital heart defects. The primary cause of short stature in Turner syndrome and Noonan syndrome is GH resistance [1]. Recombinant human growth hormone (rhGH) is being used to promote linear growth in short children with Noonan syndrome. However, its efficacy is still controversial.<p c...

hrp0097p2-6 | Growth and Syndromes | ESPE2023

Maternal, placental and fetal IGF-1 and IGFBP in Obese pregnancies and the effect on fetal/infantile growth

Soliman Ashraf , Hamed Noor , Ahmed Shyama , Alyafei Fawzia , Alaaraj Nada , Soliman Nada

Introduction: Placental hormones can control the transfer of maternal nutrients to the fetus and modulate fetal and neonatal growth. Data about the interaction between maternal, placental and fetal IGF1/IGFBP in relation to newborn size is not clear,Aim: To review research paper published in Pubmed, Google scholar, Research gate, and Scopus in the past 20 years on the relation between maternal, placental and fetal/infant...

hrp0098p1-174 | Pituitary, Neuroendocrinology and Puberty 2 | ESPE2024

International Practice in Management of Puberty for Patients with Hypogonadotropic Hypogonadism

Castro Sebastian , Rohayem Julia , Varughese Rachel , Bonomi Marco , Butler Gary , Candler Toby , Cole Tim , Dattani Mehul , Heger Sabine , Jayasena Channa , Krone Nils , Nordenstrom Anna , Senniappan Senthil , Wood Claire , Bryce Jillian , Ahmed Faisal , Howard Sasha

Background: Hypogonadotropic hypogonadism, a condition of central hypogonadism secondary to deficiency of gonadotropin releasing hormone and/or gonadotropins, is a rare disease affecting approximately 1 in 5000-15,000. A key step in improving understanding of best practice in this condition is the collection of geographically widespread data. Standardised and accessible international data collection can facilitate this, with implementation of established proto...

hrp0098p2-354 | Late Breaking | ESPE2024

The IGF1 generation test as a tool to predict growth response to growth hormone treatment in children with growth hormone deficiency

Kherra Sakina , Ouarezki Yasmine , Djermane Adel , Sahli Hassiba , Sifour Latifa , Bellouti Sihem , Mohamedi Kahina , Boutaghane Noureddine , Bouferoua Fadila , Bensalah Meriem , Ladjouze Asmahane , Ait abdelkadder Belaid , Coutant Régis , Zoulikha Zeroual

Introduction: Serum levels of insulin growth factor (IGF1) could be a good indicator of growth hormone (GH) sensitivity and potentially GH therapy responsiveness. Few studies analyzed IGF1 generation test as predictor factor of the growth response to GH treatment in children with growth hormone deficiency (GHD) but results were controversial.Objective: The aimof the study was to evaluate the IGF-I generation test (IGF-I ...

hrp0089p2-p125 | Fat, Metabolism and Obesity P2 | ESPE2018

Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Egyptian Obese Children and Adolescents: Relation to Hypertension Risk

Hamza Rasha , Elkabbany Zeinab , Kamal Tarek , Sedhom Mina

Background: Angiotensin converting enzyme (ACE) is a possible candidate gene that may influence both body fatness and blood pressure. Although several genetic studies have been conducted in adults, relatively few studies have examined the contribution of ACE candidate genes for development of the obesity-hypertension phenotype early in life.Aim: To screen Egyptian obese children and adolescents for insertion/deletion (I/D) polymorphism in the gene encodi...

hrp0086fc3.6 | Pituitary | ESPE2016

Pegvisomant is More Effective in Stunting Growth than Somatostatin Analogs in Childhood Acromegaly/Gigantism

Thomas-Teinturier Cecile , Simonin Gilbert , Vaczlavik Anna , Ajaltouni Zaina , Gaillard Stephan , Bougneres Pierre , Chanson Philippe

Background: We describe our experience in medical therapy for invasive somatotroph pituitary macroadenomas in 8 children or adolescents presenting with acromegaly/gigantism, in terms of growth and IGF-I levels control.Patients: Eight children, aged 5 to 17 years (median 12.4 years), presented with growth hormone (GH) hypersecretion related to somatotroph pituitary macroadenomas with cavernous sinus invasion in 6/8. Genetic testing revealed AIP mutation i...

hrp0094p2-252 | Growth hormone and IGFs | ESPE2021

Pappalysins and stanniocalcins in prenatal and postnatal life

Martin-Rivada Alvaro , Campillo-Calatayud Ana , Guerra-Cantera Santiago , Sanchez-Holgado Maria , Angel Martos-Moreno Gabriel , Soriano-Guillen Leandro , Pellicer Adelina , Barrios Vicente , Argente Jesus ,

Background: The human growth pattern varies from intrauterine to extrauterine life, with the GH-IGF axis being immature at birth and IGF-I assuming an important role in promoting postnatal growth. The actions of IGF-I are modulated by its interactions with IGFBPs, with this interaction being regulated by pappalysins (PAPP-A, PAPP-A2) and stanniocalcins (STC-1, STC-2), and thus modifying the amount of free IGF-I.Objective:</strong...

hrp0097p2-47 | GH and IGFs | ESPE2023

The Interaction between Growth Hormone (GH) -Insulin-like Growth factor 1 (IGF1) axis and Immune Systems in Infants and Children During undernutrition: Newly Discovered Pathological mechanisms.

Soliman Ashraf , Alaaraj Nada , Rogol Alan , Alyafei Fawzia , Hamed Noor , Ahmed Shayma , Soliman Nada

Accumulating evidence indicates various interactions between the GH-IGF1 axis and the immune system in infants and children during undernutrition.Objectives and Methods: We performed electronic literature systematic review using PubMed, Google Scholar, and Web of Sciences with the aim to provide an update on the link between the GH-IGF1 axis and the immune system in infants and children during malnutrition. We reviewed 22 studies (2007-2...