hrp0094p1-62 | Diabetes B | ESPE2021

Epidemiology of type 1 diabetes in children and adolescents: a 50-year, single center experience

Vuralli Dogus , Ozon Z. Alev , Gonc E. Nazli , Ardicli Didem , Jalilova Lala , Gulcek Omer Nazım , Alikasifoglu Ayfer ,

Introduction: Global variations in epidemiology of type 1 diabetes (T1D) exist worldwide. This study is designed to determine the demographic and clinical characteristics of T1D in the past three decades, and to analyze changing trends in epidemiology over the past 50 years.Methods: Epidemiological and clinical characteristics of 925 patients with T1D were analyzed in three decades between 1991 and 2019. In addition, pre...

hrp0097fc6.2 | Pituitary, neuroendocrinology and puberty 1 | ESPE2023

The role of body composition and appetite-regulating hormones in idiopathic central precocious puberty and their changes during GnRH analogue therapy.

Tarçın Gürkan , Bayramoğlu Elvan , Güneş Kaya Didem , Karakaş Hasan , Turan Hande , Evliyaoğlu Olcay

Aim: This study aimed to compare the levels of appetite-regulating hormones (ghrelin, leptin, peptide-YY (PYY), neuropeptide-Y (NPY)) in girls with idiopathic central precocious puberty (ICPP) before treatment with prepubertal girls, and to evaluate changes in these hormone levels and body composition during leuprolide acetate (LA) treatment.Methods: This prospective, cross-sectional study included girls with ICPP, isola...

hrp0097p2-66 | Diabetes and Insulin | ESPE2023

Physician and Family Awareness in the Diagnostic Process of Newly Diagnosed Type-1 Diabetes Mellitus

Kahveci Ahmet , Helvacıoglu Didem , Kelestemur Elif , Kurt Ilknur , Turan Serap , Guran Tulay , Bereket Abdullah , Haliloglu Belma

Aim and Method: Diagnosis of type 1 diabetes (T1DM) may be delayed in some children, despite seeking medical care by the family. In this prospective/observational study, the time and process from consulting with a doctor to getting diagnosed with diabetes was investigated in patients hospitalized for newly diagnosed T1DM between 2021-2022.Results: During the study period total of 114 newly diagnosed T1DM patients (49%F, ...

hrp0098p1-265 | Growth and Syndromes 4 | ESPE2024

Use of Vosoritide in Children with Achondroplasia - Real Life Experince

Kahveci Ahmet , Helvacıoglu Didem , Yavas Abalı Zehra , Tugba Canbaz Aylin , Gunay Aylin , Bereket Abdullah , Demircioglu Turan Serap

Aim and Method: Achondroplasia is the most common form of short-limbed dwarfism, characterized by mutations in the FGFR3 gene. Vosoritide, a C-type natriuretic peptide analog, has shown promise in promoting linear growth in children with achondroplasia. This study aims to present the real-life experiences of using vosoritide in children diagnosed with achondroplasia.Method and Results: A prospective study was conducted o...

hrp0098p2-85 | Diabetes and Insulin | ESPE2024

Clinical Characteristics and follow-up of Type 2 Diabetes in Children and Adolescents: A Single Center Experience

Güneş Nazlı , Helvacıoglu Didem , Gurpinar Tosun Busra , Yavas Abali Zehra , Guran Tulay , Haliloglu Belma , Bereket Abdullah , Serap Turan

Aim: This study aims to investigate the presentation characteristics, follow-up, and treatment modalities in children and adolescents diagnosed with Type 2 Diabetes (T2D).Materials and Methods: This retrospective chart review includes 50 patients aged 4-20 years diagnosed with T2D between February 2013 and October 2023 according to American Diabetes Association (ADA) criteria in pediatric endocrinology clinic of a univer...

hrp0098p2-304 | Late Breaking | ESPE2024

Basal Ganglia Calcification in Children with Hypoparathyroidism and Pseudohypoparathyroidism: Characterization of Relationships and Clinical and Laboratory Findings

Gurpinar Tosun Busra , Kurt Ilknur , Helvacioglu Didem , Yavas Abali Zehra , Guran Tulay , Bereket Abdullah , Jüppner Harald , Turan Serap

Background: Hypoparathyroidism (HP) and pseudohypoparathyroidism (PHP) are conditions associated with basal ganglia calcification (BGC) which is thought to be caused by high serum calcium-phosphorus product and inadequate management of hypocalcemia. Novel mechanisms have recently been proposed for phosphate sensing and transport. However, the exact pathophysiology of BGC remains to be elucidated.Objective: To gain furthe...

hrp0092p1-207 | Fetal, Neonatal Endocrinology and Metabolism (to include Hypoglycaemia) (1) | ESPE2019

Clinical characteristics and long term follow up of 17 patients with permanent neonatal diabetes due to PTF1A distal enhancer mutations

Demirbilek Huseyin , Cayir Atilla , DeFranco Elisa , Kor Yilmaz , Yildiz Melek , Yildirim Ruken , Baran Riza Taner , Demiral Meliha , Haliloglu Belma , Flanagan Sarah E , Ellard Sian , Hussain Khalid , Ozbek Mehmet Nuri

Background: Pancreas transcription factor-1 alpha (PTF1A), encoded by the PTF1A gene, is a beta helix loop(bHLH) protein which involved in the development of the pancreas and cerebellar neurogenesis. Although mutations of PTF1A cause permanent neonatal diabetes(PNDM), pancreas agenesis and cerebellar agenesis, PTF1A enhancer mutations reported causing PNDM and isolated pancreas agenesis. In the present study, we evaluate the phenotyp...

hrp0095fc6.6 | Sex Development and Gonads | ESPE2022

Breast ultrasonography: How useful in the diagnosis of precocious puberty?

Helvacıoğlu Didem , Bıyıklı Erhan , Buğdaycı Onur , Turan Serap Demircioğlu , Güran Tülay , Bereket Abdullah

Context: Assessment of breast development by physical examination(PE) can be difficult especially in overweight girls and in early stages. We aimed to study ultrasonography(USG) on evaluation of breast tissue in girls with breast development< 8 years of age.Patients and Methods: In this prospective study, 125 girls (age 7.1&pm;1.5 years) with early breast development were evaluated by breast USG for ultrasonographic b...

hrp0095p1-21 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

Etiological analysis of hypophosphatemia: A single-center experience

Eltan Mehmet , Alavanda Ceren , Yavas Abali Zehra , Bayramoglu Elvan , Betul Kaygusuz Sare , Helvacioglu Didem , Gurpinar Tosun Busra , Seven Menevse Tuba , Ata Pinar , Guran Tulay , Bereket Abdullah , Turan Serap

Background: Hereditary hypophosphatemia (HH), is a rare condition related to decreased renal tubular phosphate reabsorption. Although X-linked hypophosphatemia (PHEX mutation) is the most frequent cause of HH, recent advances in the next-generation sequencing (NGS) techniques enable the identification of various genetic etiologies. Our study aims to determine the molecular etiology of patients with hypophosphatemia and to identify new candidate genes....

hrp0095p1-193 | Thyroid | ESPE2022

Diagnostic Features and Risk Factors for Childhood Thyroid Cancers

Sahin Pinar , Gurpinar Tosun Busra , Cemal Yumuşakhuylu Ali , Guran Tulay , Helvacioglu Didem , Yavas Abali Zehra , Haliloglu Belma , Oysu Cagatay , Bereket Abdullah , Turan Serap

A worldwide increase in pediatric thyroid cancers incidence over the years has been observed. Although pediatric thyroid cancers tend to have a more aggressive course compared to adults, the survival rate is better. In this study, we aimed to examine the demographic, clinical, pathological, and laboratory characteristics, prognostic and risk factors of children with thyroid cancer.Methods: We retrospectively analyzed 39 children with thy...