hrp0089p1-p253 | Thyroid P1 | ESPE2018

Long Term Comparison between Liquid and Tablet Formulations of L-Thyroxine (L-T4) in the Treatment of Congenital Hypothyroidism (CH)

Vigone Maria Cristina , Ortolano Rita , Vincenzi Gaia , Pozzi Clara , Ratti Micol , Assirelli Valentina , Vissani Sofia , Cavarzere Paolo , Mussa Alessandro , Gastaldi Roberto , Mase Raffaella Di , Street Maria Elisabeth , Trombatore Jessica , Weber Giovanna , Cassio Alessandra

Introduction: Few studies have been published comparing the liquid and tablet formulations of L-T4 in pediatric patients, with a short follow-up period. Both formulations seemed to produce a rapid normalization of thyroid fuction with a tendency of a greater TSH inhibition in children taking the L-T4 liquid drops. The aim of our study is to compare the long-term effectiveness and saftey of both liquid and tablet L-T4 therapy in CH patients up to 3 years old via a multicenter s...

hrp0098rfc13.1 | Pituitary, Neuroendocrinology and Puberty 2 | ESPE2024

MRI-based radiomics of the pituitary gland is highly predictive of CentralPrecocious Puberty in girls: pilot study

Petraroli Maddalena , Dora Patianna Viviana , Maddalo Michele , Masetti Marco , Ormitti Francesca , Fulgoni Alice , Gnocchi Margherita , Piccolo Benedetta , Claudia Turco Emanuela , Sverzellati Nicola , Ghetti Caterina , Maria Roberta Esposito Susanna , Elisabeth Street Maria

Introduction: The diagnostic gold standard for Central Precocious puberty (CPP) is the gonadotropin-releasing hormone (GnRH) stimulation test. MR imaging of the brain (MRI) and the hypothalamus-pituitary region is required to exclude organic causes.Objective: The aim of the study was to explore a radiomic model that could assist physicians in the diagnostic workup of CPP.Methods: 4...

hrp0095p1-144 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Precocious puberty and other pubertal disorders in females during the Italian lockdown and the coronavirus 2019 (COVID-19) pandemic

Stagi Stefano , Elisabeth Street Maria , Sartori Chiara , Ferrari Vittorio , Petraroli Maddalena , Messina Giulia , Lattanzi Claudia , Insalaco Anna , Gnocchi Margherita , Alberghi Francesca , Righi Beatrice , Buia Veronica , Lucaccioni Laura , Messa Federica , Varriale Gaia , Bencini Erica , Ricci Franco , Predieri Barbara , Iughetti Lorenzo

Background: At present few data have clearly showed an increased frequency of idiopathic central precocious puberty (CPP) in females during the COVID-19 pandemic. The role of environmental factors is not fully understood and various hypotheses have been formulated.Aims of the study: To evaluate retrospectively the incidence of newly diagnosed CPP and other pubertal disorders (Premature thelarche, early puberty, fast pube...

hrp0092p2-171 | GH and IGFs | ESPE2019

Final Height in GH-deficient Paediatric Patients: A Nationwide Experience

Zucchini Stefano , Lonero Antonella , Bellone Simonetta , Bozzola Mauro , Cassio Alessandra , Felicia Faienza Maria , Giacomozzi Claudio , Grandone Anna , Guzzetti Chiara , Iughetti Lorenzo , Parpagnoli Maria , Salerno Mariacarolina , Elizabeth Street Maria , Tornese Gianluca , Wasniewska Malgorzata , Delvecchio Maurizio

Background: The primary goal of GH treatment in GHD children and adolescents is to normalize height, in order to attain an adult height within the target height (TH) range.Aim: to investigate height improvement in GHD paediatric patients treated with GH in our Country.Subjects: 737 patients with isolated GHD (39.5% females) from 13 tertiary Centres for Paediatric Endocrine Care...

hrp0098rfc14.1 | Fetal and Neonatal Endocrinology | ESPE2024

The LIFE-MILCH project: preliminary data from the risk assessment model of exposure to Endocrine Disrupting Chemicals (EDCs) in mother-infant dyads during the first 3 months of life.

Righi Beatrice , Alberghi Francesca , Pelosi Annalisa , Fontana Marta , Sartori Chiara , Davolio Emanuela , Rotteglia Cecilia , Catellani Cecilia , Buia Veronica , Shulhai Anna-Mariia , Paterlini Silvia , De Fanti Alessandro , Nuti Francesca , Real Fernandez Feliciana , Fanos Vassilios , Maria Papini Anna , Palanza Paola , Elisabeth Street Maria

Introduction: The ongoing LIFE-MILCH project (www.lifemilch.eu), focuses on detecting EDCs in mothers, in breast milk (BM) and in urine, and in infants from birth up to 12 months of age studying relationships with neurodevelopment, growth, distribution of adiposity, pubertal stages, and ano-genital distances, life-style sources (questionnaires) of exposure to establish a risk assessment model to prepare safety guide...

hrp0098p1-245 | Fetal and Multisystem Endocrinology | ESPE2024

The LIFE-MILCH study: first data on the exposure to Endocrine Disrupting Chemicals (EDCs) in urine and breast milk (BM) from end of pregnancy to 12 months of life.

Alberghi Francesca , Righi Beatrice , Pelosi Annalisa , Fontana Marta , Sartori Chiara , Davolio Emanuela , Rotteglia Cecilia , Catellani Cecilia , Buia Veronica , Shulhai Anna-Mariia , Paterlini Silvia , De Fanti Alessandro , Nuti Francesca , Real Fernandez Feliciana , Fanos Vassilios , Maria Papini Anna , Palanza Paola , Elisabeth Street Maria

Introduction: The ongoing LIFE-MILCH project (www.lifemilch.eu) focuses on detecting EDCs in mothers, in BM and in urine, and in infants from birth up to 12 months of age studying relationships with neurodevelopment, growth, distribution of adiposity, pubertal stages, ano-genital distances, life-style and professional sources of exposure (questionnaires) to establish a risk assessment model to prepare safety guideli...

hrp0082p1-d1-112 | Fat Metabolism & Obesity | ESPE2014

Mir-146a and -155 are Involved in FOXO1 Regulation and Non Alcoholic Fatty Liver Disease in Childhood Obesity

Montanini Luisa , Lazzeroni Pietro , Sartori Chiara , Nobili Valerio , Crafa Pellegrino , Bernasconi Sergio , Street Maria E

Background: Non alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in childhood, in obese subjects and associated with insulin resistance.FOXO1 is a key regulator in insulin signalling and in intracellular adipogenesis, and is implicated in liver steatosis. We have previously identified that a group of miRNAs are involved in its epigenetic regulation.Objective and hypotheses: We aimed to assess in liver tissue and in serum whe...

hrp0082fc3.1 | Diabetes | ESPE2014

High Mobility Group Box-1 Serum Concentrations Increase at Onset of Diabetes in Cystic Fibrosis Patients

Montanini Luisa , Smerieri Arianna , Pisi Giovanna , Giardino Ida , Ziveri Maria Angela , d'Apolito Maria , Cesari Silvia , Spaggiari Cinzia , Merli Silvia , Bernasconi Sergio , Street Maria E

Background: The DNA-binding High Mobility Group Box-1 (HMGB1) is an intracellular gene regulator that can be secreted also in response to inflammatory mediators, including interleukins, binding subsequently to both RAGE and Toll-like receptors forming a self-reinforcing inflammatory circle. Cystic fibrosis (CF) is a condition characterized by chronic inflammation. Elevated serum HMGB1 concentrations were described in serum of obese children and to be associated with the metabo...

hrp0095p1-303 | GH and IGFs | ESPE2022

Short stature due to a novel missense variant (695C>A) in the GHR gene: a case report.

Righi Beatrice , Trimarchi Gabriele , De Fanti Alessandro , Garavelli Livia , Sartori Chiara , Elisabeth Maria

Introduction: Laron Syndrome (LS) or primary growth hormone (GH) insensitivity is an autosomal recessive disorder due to variants in the GH-receptor (GHR) gene or to post-receptor defects. LS prevalence is estimated 1-9/1000000. We report a case of LS with a missense variant in the GHR gene not previously described.Case: female, Turkish, was referred to our clinic for short stature. Born at term, birth ...

hrp0097p1-359 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

An Evaluation of coping strategies in girls diagnosed of central precocious puberty before and after the COVID-19 lockdown, and in their mothers: preliminary study.

E Street Maria , Rollo Dolores , Rossi Maurizio , Sartori Chiara , Petraroli Maddalena , Pilloni Simone , Francavilla Roberta , Lattanzi Claudia , Miglioli Irene , Iughetti Lorenzo , Stagi Stefano

During the COVID-19 pandemic, a significant increase in Central Precocious Puberty(CPP) has been observed worldwide. The reasons for this phenomenon are yet unclear. In order to evaluate if fear, stress and coping strategies used by children and parents when dealing with negative emotional situations and health issues might have acted as triggers for this phenomenon, we administered specific questionnaires to girls who had a diagnosis of CPP before and after the COVID-19 relat...