hrp0084p3-660 | Bone | ESPE2015

4 Years Follow-Up for 25OHD and iPTH in Vitamin D Substituted Patients with Diabetes Mellitus 1: An Unicentric Prospective Study

Weissenbacher Claudia , Roeb Julia , Sydlik Carmen , Pozza Susanne Bechtold Dalla , Marx Michael , Schmidt Heinrich

Background: Vitamin D deficiency/insufficiency seems to occur frequently in children and teenagers but it is a matter of debate if limits (<20 ng/ml; <30 ng/ml) are correct. Besides its effect in bone metabolism Vit-D is also supposed to have a positive influence in diabetes mellitus 1 (DM1).Objective and hypotheses: To study 25OHD and iPTH values in a group of patients (pts) (n=57) with DM1 without Vit-D substitution (2011), with 1000 I...

hrp0084p3-741 | Diabetes | ESPE2015

Low fT3 Syndrome due to Metabolic Acidosis/Ketoacidosis in Type 1 Diabetes Mellitus (Type 1 DM)

Demikhova Irina , Pozza Susanne Bechtold Dalla , Weissenbacher Claudia , Sydlik Carmen , Roeb Julia , Schmidt Heinrich

Background: Type 1 DM is an autoimmune disease, characterized by destruction of the insulin-producing beta-cells in the islets of Langerhans. The absolute insulin deficiency leads to metabolic imbalance with hyperglycaemia, acidosis and proneness to ketosis. This acute disturbance can change thyroid hormone metabolism.Objective and hypotheses: To examine the influence of metabolic acidosis/ketoacidosis in type 1 DM on thyroid hormone levels.<p class=...

hrp0097p2-155 | Adrenals and HPA Axis | ESPE2023

A case of Ectopic ACTH in a girl with thymic carcinoid

Deodati Annalisa , Bizzarri Carla , Ubertini Graziamaria , Carmen Garganese Maria , Stigliano Antonio , Cappa Marco

Background: Ectopic ACTH-producing tumors rarely occur in children, with <1% of all adolescents with Cushing Syndrome (CS). Many cases of ACTH-secreting ectopic neuroendocrine tumors (NETs) are reported in literature. In most patients, tumors secrete corticotropin-like peptides and/or corticotropin releasing factor (CRF)-like peptide, which stimulate cortisol hyperproduction.Background: Ectopic ACTH-producing tumors r...

hrp0098rfc10.3 | Multisystem Endocrine Disorders | ESPE2024

Anthropometric changes in survivors of childhood acute lymphoblastic leukemia treated on the Italian Association of Pediatric Hematology and Oncology protocols without radiotherapy in the last two decades: preliminary data from an Italian tertiary center.

Bruzzi Patrizia , Cattini Umberto , Deonette Elisa , Gargiulo Cano Carmen , Palazzi Giovanni , Iughetti Lorenzo

Background: Previous research demonstrated that survivors of childhood acute lymphoblastic leukemia (ALL), treated on the Italian Association of Pediatric Hematology and Oncology (AIEOP) protocols without radiotherapy between 1989 and 2000, generally achieve a normal final height with a body mass index (BMI) within the normal range. Nevertheless, their height catch-up growth is not fully restored after chemotherapy and BMI increases during treatment. In female...

hrp0098p3-244 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2024

A rare cause of Secondary Amenorrhoea: Sertoli-Leydig cell tumour of ovary associated with DICER-1

Gunasekara Buddhi , McGlacken- Bryne Sinead , MacDonald Nicola , Soto Carmen , El-Khairi Ranna

Background: Secondary amenorrhoea occurs in approximately 8% of adolescent females. Ovarian and adrenal tumours are rare causes of secondary amenorrhoea. Ovarian Sertoli-Leydig cell tumours (SLCT) are rare sex-cord stromal tumours of the ovary, accounting for <0.5% of all primary ovarian neoplasms. SLCTs affect all age groups, 75% detected in second and third decade of life (mean age 25 years) and <10% detected following menopause. Testicular-like tumour...

hrp0098p1-308 | Late Breaking 2 | ESPE2024

Empowering diabetes self-management and peer connections – The role of a community young adult diabetes specialist nurse (CODSN) and diabetes youth worker (YW) in improving outcomes, Transition Safe and Sound (TraSS), an NHS England pilot.

Carden Kelly , Schlesinger Sarah , Kumaran Anitha

Aim: Transition to adult diabetes services is associated with deterioration in service experience and outcomes. We aimed to increase the uptake of structured education and provide opportunities for peer support. We describe the early outcomes of the innovative Transition (NHSE) pilot TraSS, to improve services for 16–24-year-old young adults (YA).Method: CODSN and YW met with YA in clinics and gained consent to inc...

hrp0097p1-585 | Thyroid | ESPE2023

Papillary thyroid carcinoma incidentally discovered in young patients - a case series

Grosu Iustina , Dumitrache Sabina-Maria , Zubaci Ana , Stan Raluca , Cima Luminita-Nicoleta , Vasilache Simona , Martin Sorina-Carmen , Sirbu Anca-Elena , Soare Iulia , Barbu Carmen-Gabriela , Miron Adrian , Terzea Dana , Fica Simona

Introduction: Thyroid carcinoma in pediatric and young adult population presents contradictory features: it has higher rates of multifocal disease, local and distant metastasis and reccurence compared to the adult population, yet the 5-year survival rate is 98%. The rising incidence seen recently cannot be entirely explained by overdiagnosis, as increasing rates of advanced-stage disease are also observed. The rise consists primarily of papillary thyroid carci...

hrp0095rfc8.6 | Diabetes and Insulin | ESPE2022

Short-term effects of elexacaftor/tezacaftor/ivacaftor modulator therapy on glucose tolerance in young people with cystic fibrosis

Korten Insa , Kieninger Elisabeth , Krueger Linn , Bullo Marina , E. Flück Christa , Latzin Philipp , Casaulta Carmen , BoettcherClaudia

Background: CFRD is a unique subtype of diabetes mellitus, distinct from type 1 and type 2, harbouring β-cell dysfunction and β-cell loss and insulin resistance. Modulator therapies directly target the underlying defect of CF, modulating or correcting the function of the CFTR gene (mutation-specific). Few studies investigated the effect of modulators on CFRD and glucose metabolism. We performed an observational study on the short-term effects of the ...

hrp0089p2-p128 | Fat, Metabolism and Obesity P2 | ESPE2018

Leptin and Cytokines are Not the Best Markers for Metabolic S

Cuartero Beatriz Garcia , Vergaz Amparo Gonzalez , Lacalle Concepcion Garcia , Escudero Veronica Sanchez , Salado Laura Sanchez , Larramendi Carmen Hernando de

Introduction: Leptin, some cytokines and triglycéride/colesterol -HDL ratio (TG/C-HDL ratio) are markers of insulin-resistance in children and adolescents with overweight/obesity. Due to the high prevalence of this pathology it’s necessary to find and easy and better routinely marker that identify these patients in the outpatient clinic. Previous results demonstrated that TG/C-HDL ratio >2 was a better predictor of metabolic syndrome (sensitivity 100%; specificit...

hrp0086p2-p83 | Adrenal P2 | ESPE2016

Testicular Adrenal Rest Tumors in two Young Patients with Congenital Adrenal Hyperplasia

Daniela Belceanu Alina , Bursuc Anamaria , Armasu Ioana , Constantinescu Georgiana , Crumpei Felicia , Matasariu Roxana , Christina Ungureanu Maria , Mogos Voichita , Vulpoi Carmen

Background: Testicular adrenal rest tumours (TART) may develop in males with congenital adrenal hyperplasia (CAH), with a widely variable prevalence. Having no malignant features, there seems to be no need to remove them. However, these lesions may increase in size and number when exogenous hormone therapy is inadequate. Untreated, may lead to infertility and irreversible damage of the surrounding testicular tissue.Case report: We present two cases, diag...