hrp0086rfc1.7 | Adrenals | ESPE2016

The Recovery of Adrenal Function in Children with Chronic Asthma Assessed by Low Dose Short Synacthen Test (LDSST)

Gangadharan Arundoss , McCoy Paul , McGuigan Michael , Didi Mohammed , Das Urmi , Dharmaraj Poonam , Senniappan Senthil , Ramakrishnan Renuka , Yung Zoe , Hatchard Lynn , Blundell Pauline , Stirrup Kelly , Blair Joanne

Background: Hypothalamic-Pituitary–Adrenal (HPA) axis suppression is common during inhaled corticosteroid (ICS) treatment of asthma, and deaths due to adrenal crisis are described. Little is known about the optimal treatment or recovery of ICS induced HPA axis suppression.Aims: To describe the treatment and outcomes of children with ICS induced HPA suppression diagnosed on the low dose short Synacthen test (LDSST).Method: The ...

hrp0086fc1.6 | Adrenals | ESPE2016

A Novel Syndrome of IUGR, Congenital Adrenal and Gonadal Insufficiency, Severe Infections, Thrombocytopenia and Monosomy 7 is Caused by SAMD9 Mutations

Buonocore Federica , Kuehnen Peter , Suntharalingham Jenifer , McKee Shane , Didi Mohammed , Brady Angela , Proctor Annie , Ghirri Paolo , Dimitri Paul , Blankenstein Oliver , Knoebl Dieter , Khajavi Noushafarin , Digweed Martin , Grueters Annette , Achermann John

Background: The association of intrauterine growth restriction (IUGR), adrenal insufficiency and gonadal dysgenesis is well recognised. Some children have been reported to develop monosomy 7 and myelodysplasia. However, the genetic basis of this condition was poorly understood.Objective and hypotheses: Our aim was to investigate the genetic basis of eight children with IUGR, adrenal insufficiency and gonadal failure and additional features including seve...

hrp0094p2-377 | Pituitary, neuroendocrinology and puberty | ESPE2021

Use of Tolvaptan in a child with SIADH post pituitary surgery

Lohiya Nikhil , Didi Mohamed , Senniappan Senthil ,

Introduction: Post-operative management of fluid and electrolyte imbalance after surgery for pituitary or suprasellar tumors could be challenging. Post-operative course could include diabetes insipidus (DI) (transient or permanent) or a classical triphasic response (initial phase of DI followed by a second phase of transient SIADH and third and final phase of permanent DI). Mainstay of management of SIADH in these patients involves fluid restriction. At times,...

hrp0089p2-p190 | Fetal, Neonatal Endocrinology and Metabolism P2 | ESPE2018

Atypical Hepatoblastoma and Wilm’s Tumour in an Infant with Beckwith-Wiedemann Syndrome and Diazoxide Resistant Congenital Hyperinsulinism

Uppal Saurabh , Senniappan Senthil , Didi Mohammad , Hayden James

Introduction: Beckwith-Wiedemann Syndrome (BWS) is a rare genetic disorder that could be associated with embryonal tumours. Genotype based categorisation of patients enables better screening strategies. We present a patient with BWS who developed atypical congenital hepatoblastoma and atypical Wilms tumour in infancy.Case Report: A 2 day old infant was referred with recurrent hypoglycaemia and high intravenous glucose requirement [>12 mg/kg/min]. He ...

hrp0086p2-p683 | Growth P2 | ESPE2016

Bone Health Index: A Potential Discriminator between Growth Hormone Deficiency and Constitutional Delay in Growth and Puberty in Adolescent Children

Patil Prashant , Dharmaraj Poonam , Povall Ann , Abernethy Laurence , Das Urmi , Didi Mohommed , Ramkrishnan Renuka , Senniappan Senthil , Blair Jo

Background: Constitutional delay in growth and puberty (CDGP), the most common cause of short stature in children, is a transient state of delayed growth, skeletal maturation and attenuated pubertal growth spurt. It is not always easy to differentiate from GH deficiency (GHD) even with robust clinical and auxological assessment, measurement of IGF1 and bone age evaluation Bone health index (BHI) is a quantitative measure of bone health calculated from a hand and wrist X-ray us...

hrp0095p2-79 | Diabetes and Insulin | ESPE2022

Association of type 1 diabetes mellitus with autoimmune diseases in children in the Department of Endocrinology-Diabetology and Nutrition at Mohammed VI University Hospital Center Oujda

Charif Hajar , Yagoubi Latifa , Ourdi Amal , Youssra Laalaoua , Assarar Imane , Messaoudi Najoua , Rouf Siham , Latrech Hanane

Introduction: Type 1 diabetes is frequently accompanied by other autoimmune diseases that can sometimes be integrated into autoimmune polyendocrinopathies. Through this work, we sought to describe the association of autoimmune diseases with type 1 diabetes in children.Patients and Methods: This is a retrospective and descriptive study, including 354 type 1 diabetic patients hospitalized in the Department of Endocrinology...

hrp0095p2-88 | Diabetes and Insulin | ESPE2022

Association of type 1 diabetes mellitus with autoimmune diseases in children in the Department of Endocrinology-Diabetology and Nutrition at Mohammed VI University Hospital Center Oujda

Charif Hajar , Yagoubi Latifa , Ourdi Amal , Laalaoua Yousra , Assarrar Imane , Messaoudi Najoua , Rouf Siham , Latrech Hanane

Introduction: Type 1 diabetes is frequently accompanied by other autoimmune diseases that can sometimes be integrated into autoimmune polyendocrinopathies. Through this work, we sought to describe the association of autoimmune diseases with type 1 diabetes in children.Patients and Methods: This is a retrospective and descriptive study, including 354 type 1 diabetic patients hospitalized in the Department of Endocrinology...

hrp0094p1-76 | Fetal Endocrinology and Multisystem Disorders A | ESPE2021

Hyperinsulinemic Hypoglycemia in a child with Peroxisomal Biogenesis Disorder due to a Novel PEX1 mutation

Lohiya Nikhil , Morris Andrew , Didi Mohamed , Senniappan Senthil ,

Introduction: Peroxisomal biogenesis disorders - Zellweger Syndrome Spectrum (PBD-ZWS) are rare disorders involving multiple systems including the central nervous system, adrenals, liver and skeleton but hyperinsulinism is not a recognized association. We present a child with PBD-ZWS due to a novel mutation in PEX1 who developed hyperinsulinaemic hypoglycaemia (HH).Case report: A 7 month old boy presented with recurrent hypoglyc...

hrp0084p1-92 | Growth | ESPE2015

Chronic Effects of Bisphenol A Administration on Growth Hormone Activity

AL-Masroori Mohammed , Hebais Mohammed , AL-Araimi Amnah , Zadjali Fahad

Background: Bisphenol A (BPA), a plastic byproduct, is a known endocrine disruptor and is types of cancers, such as prostate and ovaries, and some other health conditions, for instance diabetes and obesity. It has direct effect on reproductive system through its strong oestrogen agonist activity.Objective and hypotheses: BPA has a strong oestrogen agonist activity. And oestrogen antagonize cellular activity of growth hormone (GH), however, the effect of ...

hrp0084p1-105 | Perinatal | ESPE2015

Fluoxetine Induced Hypoglycaemia in a Patient with Congenital Hyperinsulinism on Lanreotide Therapy

Giri Dinesh , Yung Zoe , Stirrup Kelly , Didi Mo , Seniappan Senthil

Background: Lanreotide is a long acting somatostatin analogue that has been used successfully in the treatment of congenital hyperinsulinism (CHI) in patients who are unresponsive or intolerant to diazoxide. Antidepressant drugs are reported to cause alterations in blood glucose homeostasis in adults with diabetes mellitus. We report a patient with persistent CHI on Lanreotide therapy, who developed recurrent hypoglycaemia following Fluoxetine therapy.Ca...