ESPE Abstracts

Puberty is a critical period for the development and acceleration of vascular complications in Type 1 diabetes (T1D). We have shown that metformin in addition to insulin improves vascular smooth muscle function and HbA1c in T1D children over 12 months (1). We aimed to determine if children with T1D who received metformin in a randomized controlled trial (RCT) [Trial registration ACTRN126110001148976] have a sustained vascular function improvement 3 years after ceasing metformi...

Background: Several visfatin, retinol binding protein 4(RBP4) and high affinity receptor for RBP4, STRA6 (stimulated by retinoic acid) single nuclear polymorphisms’ (SNP) have been investigated regarding their relationship with obesity with controversial results.Aim: To analyze the association of two specific SNP for visfatin, RBP4 and STRA6 with anthropometric markers of obesity in children.Material and method: A case control...

Introduction: Neurodevelopmental disability (NDD) is a common problem in children health, occurring in 5–10% of the pediatric population.Aim: To evaluate the endocrine and metabolic complications described in patients with NDD.Material and method: Children with NDD, aged below 9 years old, admitted to 1st Pediatric Clinic of Children Emergency Hospital, Timişoara, România, between January 2014-March 2016 w...

Background: Polycystic ovary syndrome (PCOS) represents one of the most common complains for adolescent girls to present to endocrinologist. PCOS has the potential to affect the young person both metabolically, physically, psychologically and socially.Objective: To evaluate the metabolic and psychological consequences of PCOS in adolescent girls.Method: Adolescent girls admitted in the Endocrinology Department of Children Emergency...

Background: SIDM is not a common complication of high-dose glucocorticoid therapy (HD-GC) in pediatric practice. There are no clear generally accepted approaches to SIDM treatment. In 10 cases, we present the identified patterns of predictors, course, features of the treatment of SIDM in children and adolescents.Methods: 10 case histories of children with SIDM were analyzed. 4 boys, 6 girls, age 8-17.5 years, median 15 y...

Growth retardation in children with type 1 diabetes (T1D) is mostly associated with longterm poor metabolic control or combination with other autoimmune diseases. Although rare it could be due to growth hormone deficiency. We present eleven-year-old girl, diagnosed with T1D at age of 2y6mo., on multiple daily injections (MDI) with analogues. She is raised in poor social conditions – low parental education and income, rare follow-up due to difficult access to healthcare p...

The role of insulin-like growth factor-1 (IGF-1) in the regulation of growth of children with intrauterine growth is currently being discussed, but the final point of view has not been achieved.Aim: to study the effect of IGF-1 in the dynamics of postnatal growth of premature infants with SGA in the first 5 years of life.Material and Methods: The prospective study included prematurity with SGA (gro...

Prematurity combined with intrauterine growth retardation (small to gestational age, SGA) is a potential risk factor for adverse growth prognosis. There is insufficient evidence on this issue.Aim: to study the growth rates in preterm infants born small to gestational age, different gestational age in the first 5 years of life.Material and Methods: The prospective study included preterm infants with...

Background: Human HSD11B2 metabolizes active cortisol into cortisone and protects the mineralocorticoid receptor from glucocorticoid occupancy. Loss of function mutations in HSD11B2 gene cause a rare autosomal recessive disorder, apparent mineralocorticoid excess, resulting in low-renin hypertension and hypokalemia.Objective: We present 2 children with apparent mineralocorticoid excess. Case 1, a boy presenting at 11 yea...

Premature infants born small by gestational age (SGA) represent a potential cohort for growth retardation. However, up to the present time, questions of the frequency and severity of the growth deficit, the timing of the growth rate, the age of achievement of the population standard depending on the gestational age have been discussed.Aim: To assess the dynamics of growth of preterm infants born small by gestational age within 5 years of life, taking int...