hrp0082p3-d2-719 | Diabetes (1) | ESPE2014

Arabic Translation and Validation of the Newest Vital Sign Health Literacy Tool: a Pilot Project to Test Health Literacy of Caregivers of Children with Type 1 Diabetes in Kuwait

Al-Abdulrazzaq Dalia , Al-Haddad Muneera , AbdulRasoul Majedah , Al-Basari Iman , Al-Taiar Abdulla

Introduction: Health literacy is a recognized concept in diabetes care. The newest vital sign (NVS) is an English instrument established to test health literacy using a nutrition label. No studies looked into health literacy in the Arab world. Our aim is to translate and validate the NVS tool to Arabic then test it on a pilot of Arabic-speaking caregivers of children with type 1 diabetes.Methods: i) Production of the Arabic version: the English version o...

hrp0094p2-276 | Growth hormone and IGFs | ESPE2021

Growth Hormone Resistance; The Iraqi experience

Al-Jumaili Ali ,

Introduction: Primary growth hormone resistance or growth hormone insensitivity syndrome (Laron syndrome) is an autosomal recessive disorder caused by deletions or mutations in the growth hormone receptor gene or by post receptor defects. Laron is characterized by a clinical appearance of sever growth hormone deficiency with high levels of growth hormone in contrast to low insulin-like growth factor 1 values and in this cases are refractory to both endogenous ...

hrp0097p2-85 | Growth and Syndromes | ESPE2023

Challenges in treating delayed puberty in a girl with Marfan syndrome

Alharbi Mashael , Babiker Amir , Al Zaben1 Abdullah , Al Atawi Mohsen , Al Alwan Ibrahim , Al Dubayee Mohamed

Introduction: Marfan syndrome is an autosomal dominant disorder due to a mutation of the FBN1 gene of chromosome 15 that produces fibrillin, a connective tissue protein. Tall stature can be of a major concern especially in a girl patient. Here we discuss a case of a 13-year-old girl with MFS with tall stature and multiple associated comorbidities that pose challenges in her management for the whole family.Case Report: A ...

hrp0097p2-280 | Late Breaking | ESPE2023

Prevalence of Childhood Obesity Among Children Visited Paediatric Outpatient Clinics in Oman - A Single Centre Experience

Al-Lawati Osama , Al-Musharafi Ahmed , Al-Ghafri Shahad , Al-Harthi Hamza , Alsaffar Hussain

Introduction: Childhood obesity is a significant public health concern, affecting over 100 million children worldwide, with an overall prevalence of 13%. A previous Omani study in 2012 suggested the prevalence of childhood obesity in Oman was 12.5%.Objectives: This study aims to identify the prevalence of childhood obesity among children under the age of 13 yrs, who visited various pediatric outpatient clinics at Sultan ...

hrp0082pl2 | Immune-Based Therapies for T1D | ESPE2014

Learning from Histopathology to Design Novel Immune-Therapies for Type 1 and 2 Diabetes

von Herrath M

Study of the histopathology of human type 1 and 2 diabetes through the national pancreatic organ donor (nPOD) consortium has yielded interesting new insights that should also aid us in developing improved therapeutic approaches.1. When insulitis is observed, it usually shows a predominance of CD8 T cells, some of which are autoantigen specific (see also Coppieters et al. JEM 2012). It will be therapeutically challenging to remove/prevent CD8 mem...

hrp0097p1-451 | Fat, Metabolism and Obesity | ESPE2023

Diagnostic Journey with an 80-gene Panel in Non-syndromic Early-Onset Severe Obesity: Association of Outcomes with Metabolic Status and Hyperphagia

Tercan Ummahan , Yildiz Melek , Dilruba Aslanger Ayca , Derya Kardelen Al Asli , Poyrazoglu Sükran , Bas Fİrdevs , Darendeliler Feyza

Background: Monogenic defects are among the significant causes of early-onset non-syndromic severe obesity in childhood. Identifying the genetic cause of obesity can guide for treatment. The aim of our study is to investigate the clinical and biochemical features of patients with early-onset severe obesity and evaluate the underlying molecular diagnosis.Materials and Methods: A total of 39 patients (M/F: 22/17) with non-...

hrp0086p2-p860 | Syndromes: Mechanisms and Management P2 | ESPE2016

Referral Pattern of Children with Short Stature to a Pediatric Endocrine Clinic in Kuwait

Al-Abdulrazzaq Dalia , Al-Taiar Abdulla , Hassan Kholoud , Al-Twari Basma , Al-Osaimi Abdulaziz , Al-Busairi Iman

Background: Short stature is a prominent complaint for which children are referred to pediatric endocrinologists. Data on short stature is lacking in the Arab states in the gulf region despite the fact that treatment is easily accessible. The study aimed to describe the referral pattern, baseline characteristics, and etiological profile of children referred with short stature to a pediatric endocrine clinic in Kuwait.Method: This is a cross-sectional ret...

hrp0089p2-p341 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P2 | ESPE2018

Evaluation of Three Patients with 46,XY Gonadal Dysgenesis due to Desert Hedgehog Gene Mutations

Poyrazoglu Sukran , Aghayev Agharza , Toksoy Guven , Karaman Birsen , Avci Sahin , Al Asli Derya Kardelen , Ozturan Esin Karakilic , Altunoglu Umut , Bas Firdevs , Basaran Seher , Uyguner Oya , Darendeliler Feyza

Background: Desert Hedgehog (DHH) gene acts on early testicu-lar development, testis cord formation and differentiation of fetal Leydig cells. It also has a role in nerve sheath formation. DHH gene mu-tations is a very rare cause of 46,XY gonadal dysgenesis (GD). Gonadal tumors and peripheral neuropathy have been associated with DHH mutations.Aim: To present three patients with 46,XY GD due to novel homozygous DHH muta...

hrp0094p2-186 | Fat, metabolism and obesity | ESPE2021

Diagnostic accuracy of Tri-Ponderal mass index (kg/m3) for identifying glucose intolerance in obese children and adolescents.

Arciniegas Larry , Mogas Eduard , Tomasini Rosangela , Fabregas Ana , Clemente Maria , Yeste Diego ,

Introduction: The identification of obese patients with increased susceptibility and risk for glucose intolerance and type 2 diabetes requires an oral glucose tolerance test (OGTT). Reference values for Body mass index (BMI) and Tri-Ponderal mass index (TMI) according to age and sex of healthy children in Spain without malnutrition or obesity have recently been published (*). TMI values remain very uniform in both boys and girls from the age of 8 to 18 years, ...

hrp0084p3-824 | Endocrine Oncology | ESPE2015

Suprasellar Brain Tumours Related Endocrinopathies

Babiker Amir , Edrees Amani , Gadi Iman Al , Issa Sharefah Al , Malik Safdar , Watedi Sharief Al , Aeyadhy Ayman Al , Hassan Saeed , Otaibi Hessah Al , Jurayyan Nasir Al

Background: Brain tumours constitute the second most common tumours in childhood after leukaemia. Infra-tentorial tumours are more common. Most of the supra-tentorial tumours (STT) are in the supra or para-sellar regions. Malignant tumours are rare. The survival is 50–90% with appropriate management. However, STT and/or treatment may lead to traumatic brain injury (TBI) with endocrinopathic sequel.Methods: This is a retrospective hospital based stud...