hrp0092p1-120 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

Role of Priming in Peri-Pubertal Growth Delays: Preliminary Results of A Large Multicenter Study

Galazzi Elena , Improda Nicola , Cerbone Manuela , Soranna Davide , Moro Mirella , Fatti Letizia Maria , Zambon Antonella , Salerno Mariacarolina , Dattani Mehul , Persani Luca

Introduction: Peripubertal children with delayed puberty frequently display a poor growth rate prompting endocrine work-up. Whether priming with sex steroids should routinely be performed in these patients to improve specificity of growth hormone stimulation tests (GHST) is unclear. Treatment with sex steroids in constitutional delay of growth and puberty (CDGP) is also debated.Patients and Methods: This multicenter retr...

hrp0086rfc3.5 | Pituitary | ESPE2016

Prospective Dynamic Evaluation of Hypothalamo-Pituitary Function in 30 Cases of Paediatric Craniopharyngioma, by Hypothalamic Injury and Treatment; A Single Centre Series

Guzzetti Chiara , Losa Laura , Improda Nicola , Pang Gloria , Phatarakijnirund Voraluck , Gan Hoong-Wei , Hayward Richard , Aquilina Kristian , Ederies Ash , Spoudeas Helen A.

Background: Craniopharyngiomas are the commonest pituitary tumours of childhood. Though benign histologically, their localisation and invasive tendency can cause significant neuroendocrine morbidity and late mortality.Objective and hypotheses: To prospectively determine risk factors for neuroendocrine morbidity by longitudinal survival analysis.Method: All children with craniopharyngioma newly presenting to our quaternary centre be...

hrp0092p2-260 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Heterozygous CYP11A1 Mutation Associated with 46XY Disorder of Sexual Differentiation and Mild Adrenal Insufficiency

Bowen Philippa , Nicoll Nicky , Giri Dinesh

Background: CYP11A1 encodes the P450 side chain cleavage (scc) enzyme. This protein localises to the mitochondrial inner membrane and catalyses the conversion of cholesterol to pregnenolone which is the first and rate-limiting step in the synthesis of all steroid hormones. P450scc deficiency is a rare disorder that can present as adrenal insufficiency and varying degrees of disorder in sex development (DSD) in 46XY individuals. Typically, this disorde...

hrp0082p3-d2-739 | Diabetes (3) | ESPE2014

Cystic Fibrosis-Related Diabetes in Children and Adolescents in the Russian Federation

Kondratyeva Elena , Kapranov Nicolay , Sherman Victoria

Background: Disorders of carbohydrate metabolism in children and adolescents with cystic fibrosis occur from 5 to 12.6%, significantly increasing during the teenage period and reaching 24–50% in adults.Method: An analysis of 499 medical records was conducted. All the patients were treated in the Russian Children’s Clinical Hospital in 2012. The survey was carried out on carbohydrate metabolism and indications according to children after 12 year...

hrp0095fc7.3 | Growth and Syndromes | ESPE2022

Italian long-term data on efficacy and safety of rhGH therapy in children with SHOX deficiency: the final report of a national survey performed into ISPED Growth Study Group.

Bruzzi Patrizia , Vannelli Silvia , Scarano Emanuela , Elisabeth Maria , Parpagnoli Maria , Salerno Mariacarolina , Secco Andrea , Andrea Trettene Adolfo , Wasniewska Malgorzata , Pitea Marco , Faienza Mariafelicia , Delvecchio Maurizio , Corciulo Nicola , Tornese Gianluca , Filomena Madeo Simona , Iughetti Lorenzo

Background: Among children with idiopathic short stature, Italian data reported a prevalence of short stature homeobox-containing gene (SHOX) deficiency disorders (SHOX-D) near to 1/1.000-2.000 (1.1-15%) with a wide phenotypic spectrum. Current guidelines support recombinant human growth hormone (rhGH) therapy in SHOX-D children, but long-term data are still lacking. This national survey aims to evaluate long-term efficacy and safety of rhGH therapy in Italian...

hrp0094fc10.5 | Thyroid | ESPE2021

Adjuvant Rituximab – exploratory trial in young people with Graves’ disease

Cheetham Tim , Cole Michael , Abinun Mario , Alalhabadia Amit , Barratt Tim , Kirk Jeremy , Davies Justin , Dimitri Paul , Drake Amanda , Murray Robert , Steele Caroline , Zammitt Nicola , Carnell Sonya , Howell Denise , Prichard Jonathan , Watson Gillian , Matthews John , Pearce Simon ,

Objective: Remission rates in young people with Graves’ hyperthyroidism are 25% or less after a 2-yr course of thionamide antithyroid drug (ATD). Immunomodulatory agents could potentially improve outcome by facilitating immune tolerance. We wanted to explore whether rituximab, a B lymphocyte depleting agent, would increase remission rates when administered with a short course of ATD.Design: This was an investigator-...

hrp0098rfc13.1 | Pituitary, Neuroendocrinology and Puberty 2 | ESPE2024

MRI-based radiomics of the pituitary gland is highly predictive of CentralPrecocious Puberty in girls: pilot study

Petraroli Maddalena , Dora Patianna Viviana , Maddalo Michele , Masetti Marco , Ormitti Francesca , Fulgoni Alice , Gnocchi Margherita , Piccolo Benedetta , Claudia Turco Emanuela , Sverzellati Nicola , Ghetti Caterina , Maria Roberta Esposito Susanna , Elisabeth Street Maria

Introduction: The diagnostic gold standard for Central Precocious puberty (CPP) is the gonadotropin-releasing hormone (GnRH) stimulation test. MR imaging of the brain (MRI) and the hypothalamus-pituitary region is required to exclude organic causes.Objective: The aim of the study was to explore a radiomic model that could assist physicians in the diagnostic workup of CPP.Methods: 4...

hrp0098p2-11 | Adrenals and HPA Axis | ESPE2024

Iatrogenic adrenal insufficiency – a single centre response to increasing awareness and instituting management in non-endocrine specialities.

Tollerfield Sally , Atterbury-Todd Abigail , Wadey Hannah , Edmondson Claire , Moodey Nicola , Morris Stacey , Enright Noelle , Soo Audrey , Gan Hoong-Wei , Amin Rakesh , Shaunak Meera , Dattani Mehul , Hoskins Steve , Katugampola Harshini

Introduction: Supra-physiological doses of steroids are frequently used in the management of non-endocrine conditions, including chronic respiratory disease and epilepsy. Long-term use risks iatrogenic adrenal insufficiency (AI), necessitating professional and family education on management of intercurrent illness and adrenal crisis.Aims: To design and implement a Trust-wide pathway for steroid prescribers on the managem...

hrp0092p2-117 | Fat, Metabolism and Obesity | ESPE2019

Trends in Childhood Obesity, Underweight and Short Stature Among Urban School Children in Romania

Pop Raluca-Monica , Neagu Nicolae , Pascanu Ionela

Background: Childhood adolescence overweight and obesity are increasing in Romania, but limited information is available on their current trends.Aim: the current study aimed to analyze the trend in prevalence of weight disturbances and stunting in the past 5 years in school aged children from the Transylvania region in Romania.Material and Methods: Two cross-sectional data sets fro...

hrp0097p1-157 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Girls born small for gestational age may have an earlier pubertal development comparing to girls born appropriate for gestational age

Nicolas Georges , Haddad Nicolas

Key words: girls, small for gestational age, thelarche, pubarche, menarche.Background: Small for gestational age (SGA) babies are more prone to have an earlier onset of pubertal development and menarche. We conducted a study comparing the first menarche of small for gestational age (SGA) to appropriate for gestational age (AGA) girl newborns.Objective: The objective of the study is...