ESPE Abstracts

Background: With the increase of overweight prevalence an increasing number of women develop gestational diabetes.Objective and hypotheses: We evaluated the growth of 6902 children of mothers with gestational diabetes. The secular trends in the prevalence of children with gestational diabetes in mothers was studied during 30 years.The material consisted of children born 1974 (n=1108), 1981 (n=977), 1991 (n</em...

Background: Multiple organ dysfunction occurs in mitochondrial diseases (MDs). MDs are sometimes difficult to diagnose, because patients have solitary and/or combination of various symptoms including short stature, diabetes, myopathy, and seizure. Since plasma levels of lactate and pyruvate are not always the perfect biomarker for MDs, there are many pseudo-mitochondrial patients who are suspect for MDs. Diagnosis for MDs often requires muscle biopsy, gene analysis, and measur...

Background: Obese children are often taller than non-obese ones before puberty. Reports on the GH/IGF system in obese children are not consistent and do not explain the increased height observed. Changes in IGF1 bioavailability/bioactivity have been claimed as a possible explanation, however, no data is available regarding the expression of the IGF type 1 receptor (IGF1R) gene.Objective and hypotheses: To study the expression of IGF1R gene in obese child...

Background: Obesity has in males been associated with reduced testosterone levels during and after puberty. However, the onset and progress of puberty into fertility in obese boys remain inadequately evaluated.Objective and hypotheses: We aimed to study testicular function at the end of pubertal development (15–24 years) in males with severe childhood-onset obesity (height-adjusted relative weight exceeding 160% before the age of 7 years).<p cla...

Background: Heterozygous GHR gene variants were found in 5–8% of idiopathic short stature (ISS) children. Frequent polymorphisms within GHR coding regions, but not intronic SNPs, have been investigated in ISS.Objectives: To characterize GHR gene variants in ISS children, and to test their influence on height and the peripheral GH/IGF1/IGFBPs system.Methods: GHR gene (coding/intronic flanking...

Background: Recent research has focused on the association between obesity and health-related quality of life (HRQoL). However, the results are mixed when addressing this issue in youth and in different cultural contexts. Little is known about the impact of obesity on HRQoL of Asian adolescents.Objectives: To determine the metabolic and lifestyle correlates of HRQoL among Taiwanese obese adolescents in a hospital setting.Methods: O...

Background: Adolescence represents a period of one’s life when profound mental and physiological adjustment take place marking the transition to adult life. Obesity is a common health issue amongst Greek adolescents often following an obese childhood.Objective and hypotheses: We intended to assess the dietary, lifestyle, and metabolic profile of adolescents followed at the outpatient clinic of our hospital.Methods: 253 adolesc...

Background: Treatment compliance is one of the most important practical aspects in long-term treatments such as GH therapy.Objective and hypotheses: To evaluate the level of compliance and its association with duration of treatment and other demographic factors.Method: A prospective study with the use of validated questionnaires was conducted in the Endocrinology Department of one of the two main Pediatric Hospitals in Athens. The ...

Background: Iodine concentrations in Chilean schoolchildren are the highest in South America. This may be related to excessive sodium intake, which is associated with hypertension. However, iodine decreases blood pressure (BP), which would be a cardiovascular protective factor.Objective and hypotheses: The objective of this study is to evaluate the effects of iodine on BP and cardiovascular risk factors, despite salt intake.Method:...

Objective: To compare resistivity index (RI) in type 1 diabetic patients and normal controls, secondly to evaluate whether high RI is associated with different biomarkers of diabetic nephropathy (DN) as early detection of DN offers the best chance of delaying or possibly preventing progression to end-stage renal disease.Patients and methods: The study included 62 type 1 diabetic patients and 30 healthy volunteer of the same age and sex. Blood sample was ...