hrp0097p1-347 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Treatment of Children with Central Precocious Puberty (CPP) with Gonadotropin-Releasing Hormone agonist (GnRHa): Evaluation of The Effectiveness of Treatment and Recovery of Gonadal Function

Mohamed Duaa , Al Remeithi Sareea , Al Jneibi Sara , Elyazori Yara

Background: GnRHa is the treatment for CPP, it arrests puberty progression, slows bone age (BA) maturation, and increases pubertal height. In the last decades, the use of GnRHa has demonstrated its favorable effects on linear growth, although the net height gain and predictors of long-term outcomes remains debated. Concerns raised on thepotential negative effects of treatment on weight and reproductive function.Methods: ...

hrp0098p1-64 | Growth and Syndromes 1 | ESPE2024

Osteocalcin in infancy and early childhood correlates to growth and body composition: A longitudinal birth cohort study

Berggren Sara , Dahlgren Jovanna , Andersson Ola , Bergman Stefan , Roswall Josefine

Background: Osteocalcin, a metabolic active hormone, correlates to bone formation and inversely to BMI and waist circumference in adults.Objectives: To investigate whether osteocalcin in infancy and early childhood is related to childhood growth or body composition.Methods: A Swedish longitudinal birth cohort of 551 children, gathered blood samples from birth until 5 years of age t...

hrp0098p3-181 | Multisystem Endocrine Disorders | ESPE2024

Impact of Nutrition and Endocrinal Complications on Growth Pattern of Children with Sickle cell Disease

Shamma Radwa , Khaled Salama , Sara Eldesouky , Yasmeen Selim

Background: Growth retardation as well as metabolic and endocrine derangements are of utmost importance among the sickle cell disease (SCD) population.Objective: To determine the growth pattern in a cohort of Egyptian children with SCD and to determine the impact of endocrine complications and nutritional status on their growth pattern.Subjects and Methods: This study was a prospec...

hrp0098p3-201 | Pituitary, Neuroendocrinology and Puberty | ESPE2024

A case of Precocious Puberty in a girl with Prader-Willi Syndrome

Vaiasuso Renato , Pignatone Emanuela , Barneschi Sara , Varriale Gaia , Stagi Stefano

Background: Prader–Willi syndrome (PWS) is a rare genetic disorder caused by a loss of function of specific genes on chromosome 15. It is characterized by infantile lethargy and hypotonia causing poor feeding and failure to thrive, childhood obesity, short stature, and hypogonadism, that causes incomplete, delayed, and sometimes disordered pubertal development.1 Precocious puberty is very rare in PWS. We report a girl with PWS and idiopathic p...

hrp0095p2-89 | Diabetes and Insulin | ESPE2022

Design, certification and evaluation of an Insulin Infusion Therapy Care and Education Program (PAETII) in children/adolescents in a Pediatric Unit

J. Chueca Maria , Gabari Mercedes , Burillo Elisabeth , Berrade Sara , Herrero Sara , Francisco Laura , Lopez de Dicastillo Ana , Andres Carlos

A structured program of therapeutic education is essential to achieve a good result from the use of technology in the treatment of diabetes.Objectives: Facilitate knowledge, skills and aptitudes to patients and their families in therapy. Promote the capacity for self-management and adherence to treatment. Provide ongoing support to patients. Improve clinical outcomes, health status and quality of life.Metho...

hrp0097p1-203 | Adrenals and HPA Axis | ESPE2023

Adrenal insufficiency due to bioinactive ACTH caused by novel POMC variants

Illiano Sara , Vasaturo Sara , Andolfo Immacolata , Russo Roberta , Di Mase Raffaella , Moracas Cristina , Salerno Mariacarolina , Capalbo Donatella

Introduction: Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disease characterized by ACTH-resistant isolated cortisol deficiency. FGD usually presents with hypoglycemia, convulsions, prolonged jaundice, and marked skin hyperpigmentation in the early period of life. Several defects in MC2R, MRAP, MCM4, NNT, and TXNRD2 genes are related to FGD. In all these situations, plasma ACTH is high. By contrast, all reported cases of glucocorticoi...

hrp0097p1-489 | GH and IGFs | ESPE2023

Effects of GH therapy in patients with GHD (Growth Hormone Deficiency) on glucose homeostasis: results of a 10-years follow-up

Vasaturo Sara , Illiano Sara , Mirra Rita , Lorello Paola , Apuzzo Diletta , Di Mase Raffaella , Capalbo Donatella , Salerno Mariacarolina

Objectives: Among adverse effects of GH, a particular attention should be given to glucose homeostasis. The aim of the study was evaluate the effect of GH therapy on glucose homeostasis in children with GHD after 10 years of treatment.Methods: 30 patients (8 M/22 F, age 7.00 ± 2.61 years) with GHD at diagnosis and 30 healthy children comparable to patients for age, sex and BMI were enrolled. Glucose, insulin, HOMA-IR ...

hrp0095fc11.1 | Late Breaking | ESPE2022

Deep subcutaneous adipose tissue is associated with hyperinsulinemia in adolescents

Cerenius Sara Y. , Stenlid Rasmus , Aydin Banu , Weghuber Daniel , Bergsten Peter , Forslund Anders

Introduction: Abdominal subcutaneous adipose tissue (SAT) is subdivided into two depots by the fascia of Scarpa. The deep SAT (dSAT) and superficial SAT (sSAT) are morphologically and metabolically distinct, with dSAT reportedly being more similar to visceral adipose tissue (VAT) in terms of elevating the risk for obesity-related complications. Conversely, sSAT appears to be more similar to lower-body SAT. The relationship between dSAT and metabolic disease ha...

hrp0095p1-15 | Adrenals and HPA Axis | ESPE2022

Growth from Birth to Adult Height in Patients with Classical Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency: A Collaborative Study

Clemente María , Teresa Sandino María , Escribano Arancha , Berrade Sara , Campos Ariadna , Yeste Diego

Objective: To evaluate growth in patients with classical CAH.Patients and methods: Retrospective, longitudinal and multicentric study of patients with classical CAH due to 21-hydroxylase deficiency who had achieved adult height(AH).Excluded: boys with simple virilising forms(SV)>1-year at diagnosis. Normative Control Group:Millennials Longitudinal Growth Study(2018). According t...

hrp0095p1-269 | Fat, Metabolism and Obesity | ESPE2022

Characterization of glucose metabolism in obese and overweight children and adolescents during COVID-19 pandemic period

Polidori Nella , Giannini Cosimo , Mastromauro Concetta , Prosperi Sara , Chiarelli Francesco , Mohn Angelika

Background: COVID-19 restriction measurements have enhanced the obesity status in the pediatric population which might further contribute to obesity related glucose-insulin metabolism alterations. Therefore, we retrospectively compared anthropometric and OGTT data on obese children during the 13 years before and during the COVID-19 pandemic period.Subjects/Methods: Data from 741 obese/overweight children were retrieved a...