hrp0098p2-104 | Fat, Metabolism and Obesity | ESPE2024

Silent Dangers: How Insulin Resistance and Trimethylamine N-Oxide Fuel Early Atherosclerosis in Obese Children. A preliminary study

Simina Mihuta Monica , Stoian Dana , Paul Corina

Introduction: Insulin resistance accelerates the onset of atherosclerosis and arterial stiffness in children. Trimethylamine N-oxide (TMAO), a gut-derived metabolite linked to cardio-metabolic issues in adults, could exacerbate these conditions in children as well. This study explores how insulin resistance and serum TMAO levels relate to vascular damage in obese children.Methods: We included 60 children aged 6 to 18, di...

hrp0095p1-589 | Thyroid | ESPE2022

Familial Dysalbuminemic Hyperthyroxinemia (FDH) in Asymptomatic Child with High Free T4 and Normal TSH

Shanza Afzaal Shanza , Aljalily Sarraa , Malheiros - França Monica , Ten Svetlana

Case report: 6 yrs. old boy presented with high total T4, free T4, reverse T3, and normal total T3 and TSH. He has a history of tic disorder. Blood pressure, and heart rate were normal, no palpitations, no weight loss. Thyroid peroxidase and thyroglobulin antibodies were normal. Thyroid sonogram was normal. Family is of Hispanic origin. There was a family history of elevated T4 in the paternal uncle (half-brother of the father)Me...

hrp0089p2-p255 | Growth & Syndromes P2 | ESPE2018

Clinical and Cost-Effectiveness of GH Treatment for Children in Wales

Pop Raluca-Monica , Warner Justin T. , Gregory John W.

Background: GH treatment has been used for the last 30 years for children with short stature with varying individual responses.Objective: Analysis of final height SDS (standard deviation score) and the factors influencing it in children treated with growth hormone.Material and methods: Subjects across Wales who received GH treatment, part supervised by tertiary center staff and reached final height while on treatment, were identifi...

hrp0086p2-p491 | Fat Metabolism and Obesity P2 | ESPE2016

Anthropometric, Biological and Imagistical Methods For Assessing the Cardiovascular Risk in Obese Children

Stroescu Ramona , Bizerea Teofana , Lesovici Maria , Marazan Monica , Marginean Otilia

Background: Pediatric obesity has increased worldwide over the last decades, being diagnosed at ever-younger ages.Objective and hypotheses: Evaluation of clinical and biological parameters and changes that occur in children with obesity; metabolic syndrome (MetS) identification in the studied groups; identification, evaluation, analysis and correlation of the adipogenic factors with the carotid intima media thickness (CIMT).Method:...

hrp0084p2-191 | Adrenals | ESPE2015

Central Adrenal Insufficiency is not a Common Feature in CHARGE Syndrome

Bocca Gianni , Wong Monica , Ravenswaaij-Arts Conny van

Background: CHARGE syndrome (acronym for coloboma of the eye, heart defects, atresia of the choanae, retardation of growth and/or development, genital hypoplasia, and ear abnormalities) is caused by a mutation in the CHD7 gene. CHARGE syndrome shares features with Prader-Willi syndrome, especially regarding hypothalamic-pituitary abnormalities. In Prader-Willi syndrome, central adrenal insufficiency (CAI) during stressful conditions has been described in a large number of pati...

hrp0084p3-687 | Diabetes | ESPE2015

Correlation of Vitamin D Levels with Glycaemic Control, Total Daily Insulin Dose, BMI, and Ethnicity in Paediatric Patients with Type 1 Diabetes Mellitus

Bianco Monica , Durazo Ramon , Durazo-Arvizu Ramon , Minutti Carla

Background: Type 1 diabetes mellitus (T1DM) is an autoimmune and inflammatory process and vitamin D (VD) is thought to reduce inflammation and prevent autoimmune destruction. Studies have shown that VD has an effect on insulin secretion and sensitivity in rats. And it has been shown that adult T2DM with normal levels of VD have decreased insulin requirements. Two prior studies in Turkey looked at the relationship between VD levels and daily insulin requirement in paediatric pa...

hrp0084p3-759 | Diabetes | ESPE2015

Short-Term Use of Continuous Glucose Monitoring System in Paediatric Patients with Type 1 Diabetes Mellitus and Correlation with Short-Term Improvement in Glycaemic Control

Bianco Monica , Alesia Teresa , Durazo-Arvizu Ramon , Minutti Carla

Background: Several studies show there may be a relationship between the use of continuous glucose monitoring systems (CGMS) and improved glycaemic control in patients with type 1 diabetes mellitus (t1dm).Objective and hypotheses: The purpose of this study was to determine if there is a significant correlation between the clinical (office based) use of short-term CGMS and improvement in glycaemic control in paediatric patients with t1dm.<p class="abs...

hrp0094p2-78 | Bone, growth plate and mineral metabolism | ESPE2021

Deleting STX16 exon 4 to understand the genetic mechanisms underlying pseudohypoparathyroidism-1B and GNAS imprinting

AKSU CAGRI , Reyes Monica , Remillard Claire , He Qing , Bastepe Murat ,

Autosomal dominant pseudohypoparathyroidism type-Ib is characterized by renal parathyroid hormone resistance, with resultant hypocalcemia and hyperphosphatemia. This disorder is associated with an isolated loss of methylation at GNAS exon A/B and most patients carry maternal microdeletions in the neighboring STX16 gene. The shortest deletion overlap is a 1.2-kb region spanning STX16 exon 4 and thought to harbor a cis-acting element regulating GNAS A/B methylation. However, abl...

hrp0095fc7.2 | Growth and Syndromes | ESPE2022

Post-hoc subgroup analysis of the pivotal phase 3 study of once-weekly somatrogon vs once-daily Genotropin: results from subjects with peak stimulated growth hormone value <6.7 ng/ml

Phillip Moshe , Deal Cheri , Silverman Lawrence , Henocque Robin , Nijher Monica , Wajnrajch Michael , Wang Ronnie , Cara Jose

Objectives: Somatrogon is a long-acting recombinant human growth hormone (GH) approved by the EMA as a once weekly treatment for children with GH deficiency (GHD). The peak stimulated GH cut-off value for diagnostic criteria for GHD varies according to country-specific guidelines. The objective of this subgroup analysis of the pivotal phase 3 somatrogon study was to evaluate the primary and secondary efficacy endpoints for subjects with a peak GH value <6.7...

hrp0095lb5 | Late Breaking | ESPE2022

Incidence and Severity of Type 1 Diabetes Mellitus during COVID-19 Pandemic

Dieguez Abigayil , DeLacey Sean , Lado Juan , Levin Laura , Ranganna Adesh , Wu Margaret , E. Bianco Monica

Background: The COVID-19 pandemic continues to impact healthcare overall particularly in relation to diabetes. Initial studies showed delays in emergent healthcare utilization, decreased preventative care visits, and more severe presentations of new onset diabetes. However, the pathophysiologic relationship between COVID-19 and type 1 diabetes is not yet well understood.Objectives: Our primary objective was to compare th...