hrp0089p2-p117 | Diabetes & Insulin P2 | ESPE2018

Prevalence of and Risk Factors for Nonadherence to Insulin Among Paediatric Type 1 Diabetes Patients in Singapore

Chua Brandon , Stephanie Jamie , Lim XIn Yan , Poh Kar Men , Cheen McVin , Lim Soo Ting , Lek Ngee

Introduction: Nonadherence to insulin therapy is a significant problem worldwide, which is associated with poor health outcomes among patients with type 1 diabetes (T1D). It is important to identify the risk factors related to nonadherence to target those at higher risk of diabetic complications. In Singapore, there is a knowledge gap in understanding the risk factors for insulin nonadherence in paediatric patients with T1D.Objectives: To assess the prev...

hrp0086p1-p248 | Diabetes P1 | ESPE2016

GCK Mutations in Chinese MODY2 Patients: A Family Pedigree Report and Review of Chinese Literature

Ping Xiao Yu , Xu Xiao Hua , Lan Fang Yan , Qiong Jiang Li , Chen Chun , Liang Li , Lin Wang Chun

Background: Maturity-onset diabetes of the young, type 2 (MODY2), caused by mutations in the glucokinase (GCK) gene is rare in a Chinese population.Objective and hypotheses: We report three Chinese families with MODY2 and sequenced the GCK gene to find novo mutation.Method: Three unrelated Chinese families with MODY2 and pedigrees were investigated. In Family 1, the proband was a 7-year-old girl with impaired fasting glucose (IFG) ...

hrp0082p2-d3-610 | Turner Syndrome | ESPE2014

Therapeutic Effects of GH Combined with Low-Dose Stanozolol on Growth Velocity and Final Height of Girls with Turner Syndrome

Chen Hong-Shan , Du Min-Lian , Li Yan-Hong , Xiong Hui , Ma Hua-Mei , Chen Qiu-Li

Objective: This study aimed to investigate the therapeutic effects of recombinant human GH (rhGH) combined with low-dose stanozolol on the growth and final adult height (FAH) of girls with Turner syndrome (TS).Method: A total of 47 girls with TS were treated with rhGH (47.6–52.4 μg/kg per day) and low-dose stanozolol (20–35 μg/kg per day), starting at a mean age of 12.57±1.96 year. The control group consisted of 26 girls with TS,...

hrp0084p2-455 | Growth | ESPE2015

Effect of Aromatase Inhibitor Treatment During Adolescence on the Final Adult Height in Males with Idiopathic Short Stature

Yan-hong Li , Min-lian Du , Hua-mei Ma , Hong-shan Chen , Qiu-li Chen , Jun Zhang

Background: Aromatase inhibitors (AIS) can block the conversion of androgens to estrogens, thus can be used to delay bone maturation in males, however, the effect on improvement of final adult height (FAH) is still controversial.Objective and hypotheses: A prospective study was performed to evaluate the effect of letrozole used on the FAH in males with idiopathic short stature (ISS).Method: 55 boys with ISS and had entered puberty ...

hrp0098rfc15.2 | Late Breaking | ESPE2024

Study on effects of poly- and perfluoroalkyl substances on hormones in girls with central precocious puberty

Li Yan , Xing Yanan , Yin Xiaoqin , Yang Jiaoru , Zang Shaolian , Dong Ting , Pan Yitao , Dai Jiayin , Li Pin

Background: The pathogenesis of central precocious puberty (CPP) is complex, and exposure to environmental endocrine disruptors leading to CPP deserves attention. Poly- and perfluoroalkyl substances (PFASs) can interfere with sexual development, but there are few reports of their effects on sexual hormones and other hormones in CPP girls.Objective: To explore the levels of PFASs in CPP girls and healthy control girls age...

hrp0098p3-90 | Fat, Metabolism and Obesity | ESPE2024

Gene variants and clinical characteristics of children with sitosterolemia

Zou Chao-Chun , Gu Rui , Wang Hui , Wang Chun-Lin , Lu Mei , Miao Miao , Huang Mengna , Chen Yi , Dai Yangli , Zhu Mingqiang , Zhou Qiong

Objective: To enhance the detection, management and monitoring of Chinese children afflicted with sitosterolemia by examining the physical characteristics and genetic makeup of pediatric patients.Methods: In this group, 26 children were diagnosed with sitosterolemia, 24 of whom underwent genetic analysis. Patient family medical history, physical symptoms, tests for liver function, lipid levels, standard blood tests, phyt...

hrp0095p2-229 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

12 years follow-up of GH/PRL secreting pituitary macroadenoma in a child with McCune Albright syndrome

Wei Mei-hua , Li Yan-hong , Xie Liu-lu , Ma Hua-mei , Chen Qiu-li , Chen Hong-shan , Du Min-lian

Background: McCune-Albright Syndrome(MAS)includes fibrous dysplasia(FD), cafe-au-lait spots and gonadotropin-independent precocious puberty(PP). Adenohypophyseal hyperfunction syndromes is uncommon but may be potentially severe complication.Objective: To report a girl who has been confirmed McCune-Albright syndrome and has been found pituitary adenoma during follow-up.Methods:</stron...

hrp0095p2-254 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

Intracranial beta human chorionic gonadotropin(β-hCG)-secreting germ cell tumor in a girl with central precocious puberty

Huang Meng-tian , Zheng Ru-jiang , MA Hua-mei , LI Yan-hong , Jiang Bo , Huang Li-Bin , Guo Song , Zhang Jun , Chen Qiu-Li

Background: Precocious puberty is common in boys occasionally in girls with beta human chorionic gonadotropin (β-hCG)-secreting intracranial tumors, and is reported to be peripheral precocious puberty exclusively.Object: To described a girl with intracranial β-hCG-secreting germ cell tumor(GCT) who presented with central precocious puberty(CPP).Method:<...

hrp0098p1-11 | Bone, Growth Plate and Mineral Metabolism 1 | ESPE2024

Clinical and genetic characteristics of primary hypoparathyroidism in children a multicenter experience in China

Shen Yingxiao , Yang Wei , He Qin , Xu Xiaoqin , Sun Yan , Wang Zhihua , Yang Xiaohong , Dong Guanping , Huang Ke , Wei Haiyan , Wu Wei , Fu Junfen

This study was aimed to analyze the clinical and genetic characteristics of primary hypoparathyroidism in children from five medical centers in China. We performed a multicenter retrospective analysis of 74 patients diagnosed with pediatric primary hypoparathyroidism from 2014 to 2023 recruited in five medical centers across China. Data of basic information and clinical tests were extracted from patients’ records. WES, MLPA and CMA were utilized to identify the genetic c...

hrp0098p1-58 | GH and IGFs 1 | ESPE2024

Somapacitan is Effective and Well Tolerated in Chinese Children with GHD: 52-week Results from the Randomized Phase 3 REAL6 Trial

Fu Junfen , Cheng Xinran , Højby Michael , Gong Chunxiu , Lund Leunbach Tina , Li Yanhong , Wei Haiyan , Zhu Yu , Zhang Yining , Zhong Yan

Somapacitan is currently the only long-acting GH approved by FDA, PDMA and EMA to treat GH deficiency (GHD) in both children and adults. Similar efficacy, safety, and tolerability in children with GHD was demonstrated for somapacitan (0.16 mg/kg/week) compared to daily GH (0.034 mg/kg/day) in the global phase 3 REAL4 study, which was conducted in 20 countries within Asia (excluding China), Europe, and North America. Efficacy and safety of somapacitan in Chinese children with G...