hrp0086fc1.3 | Adrenals | ESPE2016

Steroidogenesis in the Human Fetal Adrenals at the End of the First Trimester

Savchuk Iuliia , Morvan M.L. , Soeborg T. , Antignac J.P. , Danielsson K. Gemzell , Bizec B. Le , Soder O. , Svechnikov K.

Background: Steroid hormones produced by the human fetal adrenals (HFA) are suggested to regulate intrauterine homeostasis and the maturation of certain fetal organs necessary for extrauterine life. Appropriate development and hormonal function of the HFA therefore are critical for normal fetal maturation and survival. Little is known about the possible relationship between the expression of steroidogenic enzymes and corresponding transcription factors in the HFA in vivo</...

hrp0098rfc1.5 | Diabetes and Insulin | ESPE2024

Evaluation of Arterial Stiffness in Children with Type 1 Diabetes Mellitus Using Speckle Tracking Carotid Strain Ultrasonography: Do Atherosclerotic Changes Begin in Childhood?

Gök Mustafa , Deveci Sevim Reyhan , Öztürk Sercan , Ünüvar Tolga , Anık Ahmet

Objective: The aim of this study was to evaluate the effectiveness of the Speckle Tracking Carotid Strain (STKS) ultrasonography technique, which allows the measurement of arterial stiffness and strain parameters, in the detection of early atherosclerotic findings in children with type 1 diabetes mellitus (T1DM).Materials and Methods: Children aged 7-18 years with T1DM and no other comorbidities were included in the stud...

hrp0095p1-43 | Diabetes and Insulin | ESPE2022

The spectrum of paediatric diabetes subtypes from a single center in a highly consanguineous region

Anne Amaratunga Shenali , Hussein Tayeb Tara , Nabaz Muhamad Sediq Rozhan , Karem Hama Salih Fareda , Dusatkova Petra , Pruhova Stepanka , Lebl Jan

Introduction: Monogenic diabetes has been estimated to be 1 - 6% of all diabetic cases in European countries which are primarily non consanguineous populations, while the incidence in highly consanguineous areas is insufficiently defined. However, the genetic aetiology of monogenic diabetes has been shown to be widely different in areas with prevalent consanguinity compared to areas with lower rates. In this single-centre study, we aimed to evaluate the preval...

hrp0095lb25 | Late Breaking | ESPE2022

Challenges of Gender Assignment in Disorder of Sex Development (DSD) in Developing Countries

Aftab Sommayya , Manzoor Jaida , Shaheen Tahir , Hira Noore , Talat Nabila , Bilal Muahmmad , Iqbal Nasir Sajid , Tahir Warda , Usama Aziz Muhammad , Bari Attia , Ullah Ehsan , Mansoor Bugvi Saima , Bashir Shabnam , Akber Maida

Background: Gender assignment in children with disorder of sex development (DSD) is a key step in their management and needs detailed assessment. In developing countries, children with DSD are often presented late, due to lack of awareness and social stigmatization, which makes management more challenging.Methodology: Retrospective review of complex DSD cases (karyotyping different from current sex of rearing), presented...

hrp0084p3-1179 | Thyroid | ESPE2015

Plasma Visfatin Level and Its Association with Apolipoproteins A1 and B in Hypothyroid Children

Dehkordi Elham Hashemi , Rostampour Noushin , Kasiri Karamali , Moafi Mohammad , Aramesh Mohammad Esmail , Hashemipour Mahin

Background and aim: Hypothyroidism could be accountable for cardiovascular diseases; hence, necessity of novel biomarkers being capable to predict patient’s status is indispensable. The aim of this study was to appraise alteration of plasma visfatin levels (as a newly discovered proteins) and its association with lipid profiles of hypothyroid patients.Materials and methods: In this cross-sectional, descriptive, and analytical study, 30 children bein...

hrp0094p2-114 | Diabetes and insulin | ESPE2021

Evaluation of serum myostatin levels in patients with insulin dependent diabetes mellitus

Burak Selver Muhammed , Emre Atabek Mehmet , Selver Eklioglu Beray , Kurban Sevil ,

Objective: We aimed to evaluate the relationship between serum myostatin levels and metabolic parameters in children with insulin dependent (Type 1) diabetes mellitus and to show the relationship with sarcopenia in children with insulin dependent diabetes mellitus.Methods: Forty -four patients aged between 8 and 16 years, and 45 control patients were enrolled in the study. Anthropometric measurements and laboratory analy...

hrp0089p3-p398 | GH &amp; IGFs P3 | ESPE2018

Recombinant Growth Hormone Therapy in Prepubertal Children with Idiopathic Short Stature in Korea: A Phase III Randomized Trial

Im Minji , Kim J , Suh B-K , Ko CW , Lee K-H , Shin CH , Hwang JS , Kim HS , Chung WY , Kim CJ , Han H-S , Kwon NY , Cho SY , Yoo H-W , Jin D-K

Several studies have evaluated the effects of growth hormone (GH) on auxological and biochemical parameters in children with non-GH-deficient, idiopathic short stature (ISS). This study evaluated the efficacy and safety of GrowtropinR-II (recombinant human GH) in Korean patients with ISS. This was a 1-year, open-label, multicenter, phase III randomized trial of Growtropin-II in Korean patients with ISS. In total, 70 prepubertal subjects (39 males, 31 females) betwee...

hrp0089p1-p142 | GH &amp; IGFs P1 | ESPE2018

Growth Hormone Deficiency due to Whole-Gene Deletion of GHRHR

Acar Sezer , Demir Korcan , Kırbıyık Ozgur , Paketci Ahu , Murat Erdoğan Kadri , Abacı Ayhan , Bober Ece

Introduction: Various types of mutations in GHRHR cause isolated growth hormone deficiency type 1B. Here, we report the clinical features associated with deletion of whole GHRHR gene for the first time.Case: A four-year–and-nine-month-old otherwise healthy girl was admitted due to short stature. She was born at term with a birthweight of 3750 gr. Her height velocity slowed down after 2 years of age. The mother (157.8 cm, −0.8...

hrp0097rfc5.5 | Diabetes and insulin 1 | ESPE2023

Syndrome of hypoglycemia unawareness in children with type 1 diabetes: clinical contribution of Clark and Gold questionnaire

Obermannová Barbora , Kyzlíková Kamila , Plachý Lukáš , Neuman Vít , Průhová Štěpánka , Petruželková Lenka , Koloušková Stanislava , Šumník Zdeněk

Introduction: For diagnosis of syndrome of hypoglycemia unawareness is used Clarke and/or Gold questionnaire. Frequency of this syndrome in children with type 1 diabetes (T1D) and its association with parameters of metabolic control including the CGM data are not well characterised.Aims and methods: The aim of our study was to find the prevalence of this syndrome in children with T1D (age 8-19 years) followed at our depa...

hrp0098p2-71 | Diabetes and Insulin | ESPE2024

Severe Acute Kidney Injury in an Adolescent with Diabetic Ketoacidosis

Şen Küçük Kübra , Deveci Sevim Reyhan , Feray Arı Hatice , Ünüvar Tolga , Anık Ahmet

Introduction: Acute kidney injury (AKI) is a common complication in diabetic ketoacidosis (DKA). AKI in children with DKA is often mild and transient. Severe AKI is rare.Case: A 14-year-old female presented with symptoms consistent with recent-onset diabetes mellitus, accompanied by abdominal pain, vomiting, and respiratory distress over the preceding two days. Physical examination revealed confusion with a Glasgow Coma ...