hrp0089p1-p133 | Fat, Metabolism and Obesity P1 | ESPE2018

Severe Obesity and Cardiometabolic Comorbidities in Adolescents: Chronology of an Epidemic

Pinhas-Hamiel Orit , Reichman Brian , Afek Arnon , Derazne Estela , Hamiel Uri , Furer Ariel , Gershovitz Liron , Kark Jeremy D , Bader Tarif , Twig Gilad

Aims: To assess trend in the prevalence of severe obesity in a national population-based sample of adolescents and to evaluate the association of severe obesity with major cardio-metabolic morbidities.Methods: Prevalence and severity of obesity was determined among 373,226 Israeli adolescents with abnormal BMI (≥85th percentile for age and sex) examined in an obligatory health assessment at mean age 17.3±0.5 years between 1967 and 2...

hrp0089p1-p149 | GH & IGFs P1 | ESPE2018

Assesment of SDF-1 and Ang-1 and Ang-2 in Children with Growth Hormone Deficiency before and after 1- year Therapy with Recombinant Growth Hormone

Sawicka Beata , Moniuszko Marcin , Grubczak Kamil , Singh Paulina , Radzikowska Urszula , Mikłasz Paula , Dębrowska Milena , Borysewicz-Sańczyk Hanna , Bossowski Artur

Introduction: Angiopoietins are necessary for development, differentiation and stabilization vessels progress. Angiopoient 1 (Ang-1) is responsible for vascular integrity, through stimulation of endothelial cell migration and adhesion, and inhibition of apoptosis. Action of angiopoietin 2 (Ang-2), in the absence of VEGF it Leeds to vascular regression, but in the presence of high VEGF concentration it stimulates angiogenesis. Stromal derived factor (SDF-1) play an important ro...

hrp0084fc4.3 | Growth | ESPE2015

An Updated and Final Analysis of a Randomised Placebo-controlled Trial of the Effect of Oxandrolone and Timing of Pubertal Induction on Final Height in Turner Syndrome

Gault Emma-Jane , Cole Tim J , Perry Rebecca J , Casey Sarah , Paterson Wendy F , Hindmarsh Peter C , Betts Peter , Dunger David B , Donaldson Malcolm D C

Background: While GH therapy forms the mainstay of growth promoting treatment for Turner syndrome (TS), adjunctive use of oxandrolone and optimal timing of pubertal induction remain controversial. The previously published interim analysis of this randomised double-blind placebo-controlled trial demonstrated that oxandrolone and pubertal induction at 14y vs 12y significantly increased final height. However, these effects were not additive.Objective: To up...

hrp0084p1-73 | Fat | ESPE2015

Circulating miR146a and 486-5p are Altered in Obese Children with and Without Non-Alcoholic Fatty Liver Disease (NAFLD) and Correlate with Abdominal Fat and BMI

Montanini Luisa , Patianna Viviana D , Sartori Chiara , Predieri Barbara , Bruzzi Patrizia , Lazzeroni Pietro , Merli Silvia , Bergamaschi Paolo , Bernasconi Sergio , Iughetti Lorenzo , Street Maria Elisabeth

Background: MicroRNAs (miRNA) are small non coding RNA molecules, key regulators of metabolic pathways. Obesity is characterised by many metabolic changes. NAFLD is seen as a complication of obesity. FOXO-1, key regulator in insulin signalling, has been shown to be implicated in NAFLD. We previously identified miRNAs regulators of the FOXO-1 gene.Objective and hypotheses: To assess in serum whether the regulation of miR-146a and miR-486-5p, FOXO1 gene re...

hrp0094fc7.2 | Fetal Endocrinology and Multisystem Disorders | ESPE2021

Maternal, rather than fetal, genetic variation in vitamin D metabolism is associated with umbilical cord blood 25-hydroxyvitamin D in pregnancies supplemented with cholecalciferol: findings from the MAVIDOS randomized controlled trial

Moon Rebecca , D’Angelo Stefania , Curtis Elizabeth , Cooke Laura , Davies Justin , Crozier Sarah , Godfrey Keith , Graham Nikki , Holloway John , Lewis Rohan , Cleal Jane , Inskip Hazel , Cooper Cyrus ,

Background: Neonatal vitamin D deficiency (VDD) can result in symptomatic hypocalcemia, seizures and cardiomyopathy and has been associated with reduced bone mineralization in childhood, but is potentially preventable with antenatal cholecalciferol supplementation. Single nucleotide polymorphisms (SNP) in the vitamin D metabolism pathway are associated with serum 25-hydroxyvitamin D [25(OH)D] in adulthood. We assessed whether maternal and/or offspring SNPs in ...

hrp0094p1-46 | Sex Endocrinology and Gonads A | ESPE2021

Endocrine & Molecular Genetic Findings In XY Boys Investigated For A Disorder Of Sex Development: the Glasgow Experience

Alimussina Malika , Patjamontri Supitcha , Lucas-Herald Angela K , McMillan Martin , McNeilly Jane D , Diver Louise A , Tobias Edward S , McGowan Ruth , Ahmed S Faisal ,

Introduction: Advances in diagnostic capability in the field of DSD hold great promise but need a regular review.Objectives: To study the range of endocrine and molecular genetic variation in a group of boys undergoing investigation for XY DSD.Methods: 157boys with median age of 0.9yrs (range,0,18) evaluated by the DSD Diagnostic Board in Glasgow from 2016to 2021 were included. Seq...

hrp0094p2-398 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

Evaluation of genomic copy number variations in the etiology of syndromic patients with diferences of sex development (DSD)

Antonio Diniz Faria Junior Jose , R. Moraes Daniela , L. Batista Rafael , Gomes Lisboa Natalia , D. Kulikowski Leslie , Y Nishi Miriam , B Mendonca Berenice , Domenice Sorahia ,

Differences of sex development (DSD) occurs when the development of chromosomal sex, gonadal or internal/external genitalia is atypical. It has an incidence of 1: 1000-4500 live born children. New chromosomal array technologies (SNP-array) can analyze the genome of the individual providing information of copy number variation (CNV) of specific chromosomal regions helping to identified pathogenic variants that could explain the etiology of the DSD. This study aims to analyze th...

hrp0097fc10.1 | Fetal, neonatal endocrinology and metabolism (to include hypoglycaemia) & Multisystem endocrine disorders | ESPE2023

Dasiglucagon safety in paediatric participants with CHI

Meissner Thomas , D. De León Diva , Thornton Paul , Zangen David , Mohnike Klaus , Andersen Marie , Bøge Eva , Birch Sune , Ivkovic Jelena , Banerjee Indi

Background: Congenital hyperinsulinism (CHI) is a rare disorder, which causes persistent and severe hypoglycaemia in infants and children. CHI can be treated with glucagon, but long-term use is challenging owing to its instability in aqueous solution. Dasiglucagon, a stable glucagon analogue designed for long-term use as a subcutaneous continuous infusion, is in clinical development. Here, we present dasiglucagon safety results in participants treated for up t...

hrp0097p1-152 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

The awakening of the hypothalamic-pituitary-gonadal axis in the post-COVID era; the Greek experience.

Hatziagapiou Kyriaki , Anargyros Vasilakis Ioannis- , Binou Maria , Dolianiti Maria , C. Nicolaides Nicolas , Zoumakis Emmanouil , Papathanasiou Chryssanthi , Gkougkouli Eleni , Barouti Konstantina , Kanaka-Gantenbein Christina , D. Sakka Sophia

Background: Puberty onset results from the interplay between genetic and environmental factors. During COVID-19 pandemic, children experienced epidemic-related changes, such as stress, sedentary lifestyle, excessive use of electronic devices, all leading to weight gain.Objective: The aim of our study is to retrospectively evaluate the incidence of premature activation of the hypothalamic-pituitary-gonadal axis, as eviden...

hrp0097lb6 | Late Breaking | ESPE2023

A concomitant increase in thinness and weight excess in Brazilian schoolchildren: evaluation from 2010 to 2022

M de Jesus Luciana , M Pinto Renata , B D de Sousa Mariana , P de Oliveira Nayara , de S Gomes Laís

Introduction: The Body Mass Index (BMI) is an essential indicator for the nutritional assessment of children and reflects the exposure to health conditions that are harmful to the development of this population.Objective: To analyze the temporal trends of the BMI of Brazilian children aged 5-10 between 2010 and 2022.Patients and methods: Descriptive ecological study. Data obtained ...