hrp0089p2-p041 | Bone, Growth Plate & Mineral Metabolism P2 | ESPE2018

Clinical and Biological Parameters Associated to the Severity of X-linked Hypophosphatemia in Children

Salcion-Picaud A , Rothenbuhler A , Etcheto A , Molto A , Briot K , Linglart A

Introduction: X-linked hypophosphatemia or XLH is a rare genetic disease, often revealed in children by rickets, growth failure, delayed walking, and leg bowing. Clinically the severity is reflected by leg deformities. The aim of our study was to assess the clinical and biochemical parameters correlated to the severity of XLH at the end of growth.Materiel and methods: Monocentric retrospective study of patients treated with phosphate supplements and vita...

hrp0089p2-p199 | Fetal, Neonatal Endocrinology and Metabolism P2 | ESPE2018

Evaluation of Vitamin D Status and Its Correlation with Gonadal Function in Children at Mini-puberty

Kılınc Suna , Atay Enver

Objective: Most recent evidence from conducted in human and animal studies suggests that vitamin D has a potential role in the physiology of reproductive function in both genders. We investigate the role of vitamin D in male and female gonadal function at mini-puberty period with particular emphasis on production of sex steroids and gonadal peptide hormones. Additionaly, this study evaluated serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradio...

hrp0089p3-p213 | GH & IGFs P3 | ESPE2018

Role of Insulin like Growth Factors on the Growth Parameters in Children with Acquired Hypothyroidism: An Analysis

Yadav Sangita , Goel Ruchi , Mantan Mukta , Mishra T K

Introduction: Growth retardation as clinical manifestation among children with acquired hypothyroidism is observed later in the course of the illness. Thyroid hormones along with insulin like growth factors (IGF) have important role in somatic and skeletal growth. Studies addressing role of IGF’s towards growth retardation in children with acquired hypothyroidism are limited.Objective: To evaluate effect of Insulin like growth factors in children wi...

hrp0089p2-p409 | Thyroid P2 | ESPE2018

Do Insulin Like Growth Factors also Influence Growth in Children with Congenital Hypothyroidism: A Cohort Analysis

Yadav Sangita , Goel Ruchi , Mantan Mukta , Mishra T K

Introduction: Congenital Hypothyroidism if not treated timely presents with growth & developmental delay. Thyroid hormones and Growth hormone- Insulin like growth factor 1 axis (GH-IGF-1) together are critical for somatic and skeletal growth. Hypothyroidism and derangement in this axis leads to profound growth retardation and delayed skeletal maturation. Limited studies suggest that thyroxine directly regulates IGF-1 independent of GH in congenital hypothyroidism.<p cl...

hrp0086p1-p477 | Fat Metabolism and Obesity P1 | ESPE2016

Renal Involvement ın Obese Children and Adolescents

Kaya Mehmet Sirin , Anık Ahmet , Unuvar Tolga , Sonmez Ferah

Background and aim: Epidemiologic studies have been shown that obesity increases the risk of renal disease and it impact on prognosis. In this study, we aimed to investigate both glomerular and tubular involvement in asymptomatic obese children and to investigate the association of metabolic-anthropometric parameters with renal parameters.Material-method: Children with BMI ≥95th percentile and diagnosed as primary obesity (n=43) were inclu...

hrp0086p2-p965 | Thyroid P2 | ESPE2016

An Unusual form of Precocious Puberty: Van Wyk and Grumbach Syndrome

Anık Ahmet , Avcı Esma Cigdem , Unuvar Tolga

Introduction: The association of precocious puberty and/or polycystic ovaries, delayed bone age and hypothyroidism is known as the Van Wyk and Grumbach syndrome (VWGS). Clinically this syndrome is a diagnostic challenge because hypothyroidism usually leads to pubertal and growth delay, whereas in case of VWGS hypothyroidism it leads to growth delay and precocious puberty. We report a boy with long-standing, untreated hypothyroidism who presented with precocious puberty.<p ...

hrp0082p2-d1-456 | Growth | ESPE2014

How Early is the Rise in Leptin Levels in Small for Gestational Age Children With Catch Up Growth

Gupta Ainam , Yadav Sangita , Ramji Siddharth , Mishra T K

Background: Strong association of early postnatal catchup growth in SGA with higher leptin levels and increased risk of insulin resistance has been described.Objective: To determine leptin levels in term small for gestational age (SGA) children at 15–18 months age and assess their relationship with postnatal catchup growth (CUG).Methods: Birth and current weight and length of 60 term SGA (<10thpercentile) childr...

hrp0082p2-d2-462 | Growth (1) | ESPE2014

Adiponectin Levels as Early Marker of Insulin Resistance in Children Born Small for Gestational Age in Our Cohort

Yadav Sangita , Gupta Ainam , Ramji Siddharth , Mishra T K

Background: Small for gestational age (SGA) children, especially those with postnatal catchup growth, have increased risk of insulin resistance and adult metabolic diseases. Adipokines produced by adipose tissue play crucial role in fetal growth and early postnatal life. Low adiponectin (adipokine) is marker of insulin resistance.Objective: To evaluate adiponectin levels in term SGA at 15–18 months age and its relationship with postnatal catchup gro...

hrp0082p3-d2-686 | Bone (1) | ESPE2014

I.V. Zolendronic Acid: Experience of Treatment of Children with Osteogenesis Imperfecta in Indonesia

Pulungan A , Zacharin M , Armstrong K , Soesanti F , Pramesti D L

Background: The incidence of osteogenesis imperfecta (OI) worldwide is unknown. In the USA, the incidence is ~1/20 000 live births: for Indonesia (population 240 million) this should extrapolate to 12 000 OI patients rather than the 35 patients currently registered with the Indonesian Pediatrics Society (IPS), Faculty of Medicine, University of Indonesia-Cipto Mangunkusumo Hospital (RSCM). This enormous disconnect signifies many missed diagnoses, mortality or both.<p class...

hrp0084fc11.4 | Neuroendocrinology | ESPE2015

Idiopathic Multiple Pituitary Hormone Deficiency (IMPHD): Radiological and Perinatal Factors

Ginige Nimasari , Kirk Jeremy M W , MacPherson Lesley K R

Background: Most cases of multiple pituitary hormone deficiency (MPHD) are acquired and genetic aetiology is rare in the UK. We have investigated whether environmental factors are implicated in ‘idiopathic’ MPHD (IMPHD).Objective and hypotheses: In IMPHD to determine perinatal risk factors and radiological features; to identify the regional epidemiology.Method: Systematic analysis of paediatric IMPHD cases in the UK West ...