Introduction: Abnormal levels of lipids and lipoproteins are recognized as a prominent cardiovascular risk factor associated with increased morbidity and mortality. In many studies childhood obesity has been shown to be associated with increased levels of total cholesterol (TH), triglycerides (TG), LDL-cholesterol, and decreased levels of HDL-cholesterol.
Objective: The aim of this study was to evaluate the risk of dyslipidemia (abnormal levels of all of TH, TG, LDL, and HDL-cholesterol) in adolescents with obesity.
Material and methods: The study included 272 adolescents aged 1118 who visited a pediatric endocrinologist as outpatients. All participants filled out a survey, underwent physical examination and had their blood lipid profile taken. The probability of dyslipidemia (abnormal levels of all components of lipid profile) was determined by using logistic regression.
Results: The study included 148 (54.4%) girls and 124 boys (45.6%). The average age of adolescents was 15.6±1.2 years, the average weight was 102.9±16.3 kg, and the average waist circumference was 110.0±14.2 cm. All four lipid components were abnormal in 35 adolescents (12.9%). The results showed that adolescents with weight 100 kg or more had increased risk of dyslipidemia (ExpB (95% CI)=5.74 (2.0116.4); P=0.001), other factors used in the study (waist circumference 110 cm or more, smoking, family history of myocardial infarction or diabetes mellitus) did not show a statistically significant impact on the risk of dyslipidemia (P>0.05).
Conclusion: The study showed that the risk of dyslipidemia was 5.74 times higher in adolescents with weight 100 kg or more. Other factors had no significant impact on the risk of dyslipidemia.
20 - 22 Sep 2014
European Society for Paediatric Endocrinology