ESPE Abstracts (2015) 84 P-3-1093


Relations of Birth Chest Circumference to Blood Serum IGFBP3 in the Newborn Free of Life-threatening Disease: Possible Role of Birth Body Weight Beyond Blood Serum IGF1 and Respiratory Supportive Treatment

Cesare Terzia,b, Raffaele Virdisa,b, Gabriele Tridentic, Lidia Garavellic, Andrea Ceriolid, Marco Rianid, Sergio Bernasconia,b, Gian Luigi Dé Angelisa,b, Cristiana Magnanic, Werner F Blume & Giacomo Banchinic


aDepartment of Pediatrics, Obstetrics and Gynecology; Azienda Ospedaliero-Universitaria di Parma, Parma, Emilia-Romagna, Italy; bDepartment of Clinical and Experimental Medicine; University of Parma, Parma, Emilia-Romagna, Italy; cDepartment of Pediatrics, Obstetrics and Gynecology; Arcispedale S. Maria Nuova Reggio Emilia, Reggio Emilia, Emilia-Romagna, Italy; dDepartment di Economia; University of Parma, Parma, Emilia-Romagna, Italy; eFriedrich-Stengel-Str. 14, Usingen, Hessen, Germany

Background/objective and hypotheses: Chest circumference (CC) is related to intrauterine growth rate as well as to development-function of respiratory system. We evaluated the relevance of birth body weight (BW) and blood serum IGF1 (IG1) in birth CC (BC) relations to blood serum IGF-binding-protein-3 (IB3) after control for preterm birth (PTB), oxigen (O2) supplementation as %O2 in respiratory gases (O2R) and assisted ventilation of any kind (AV) in the newborn (NWB) without life-threatening disease.

Method: Data available in each NWB: i) gender (SEX), gestational age (GA, unit:complete week), BW (unit:gr), BC (unit:cm), BW<10th centile for GA (SGA), PTB defined as GA≤36 and, ii) same-day records of postnatal age (PNA;unit:day), O2R, AV and IG1-IB3 RIA measurements (unit:μM/dl) at one of the first 5 postnatal days(x), 5 days after x(y) and 10 days after x(z). 78 NWBs without any among total parenteral nutrition, life-threatening disease, diabetes mellitus (DM), endocrine diagnosis out of DM, malformation, clinically relevant trunk trauma or DM in mother were included (male SEX,n,43; SGA,n,20; GA range=28–42; BW range=1200–4150;BC range=22.0–39.0;PTB,n,46; presence of O2R,n,x=22,y=11,z=1; presence of AV,n,x=8,y=4,z=1). Natural log-transformed IB3 (IB3-LN) resulted near-normally distributed. Multiple Linear Regression (MLR) was used (computations; male SEX, PTB, AV, condition present=1, condition absent=0).

Results: MLRs with IB3-LN as outcome showed a significant partial correlation (PC) coefficient (r) of BC PCs with IB3-LN when including as predictors either i) PNA, O2R and AV chronologically corresponding to outcome, and SEX, PTB and BC (BC vs. IB3-LNx, r=0.35, P=0.0022; BC vs IB3-LNy, r=0.47; P=0.0000; BC vs IB3-LNz, r=0.53, P=0.0000), or 2)PNA, O2R, AV and IG1 chronologically corresponding to outcome and SEX, PTB and BC (BC vs. IB3-LNx, r=0.30; P=0.0101;BC vs. IB3-LNy, r=0.30; P=0.0104;BC vs. IB3-LNz, r=0.51; P=0.0000), while MLRs showed no significant r of BC PCs with outcome IB3-LN at x, y or z when including as predictors PNA, O2R and AV chronologically corresponding to outcome, as well as SEX, PTB, BC and BW (R2 of MLR models, 0.38-0.66, significant in all cases).

Conclusion: BW appeared more able than IG1 chronologically corresponding to IB3-LN in explaining BC relations to IB3-LN after control for SEX, PTB, PNA, O2R and AV in not-life-threatened NWBs.

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