Background: The prevalence of obesity and related cardiovascular comorbodities are increasing rapidly. Adipokines play the major role on the pathogenesis of obesity related inflammation and hypertension.
Objective and hypotheses: The aim of the study was to evaulate the serum adropin levels in obese children and to determine the relationship between adropin levels and blood pressure in pediatric age group.
Method: 40 obese children (mean age: 12.5±2.5 years; male/female ratio: 18/22) and 15 healthy control (mean age: 15±3.14 years; male/female ratio: 5/15) were included to the study. Serum adropin levels, laboratory and clinical variables were compared. Ambulatory blood pressure monitoring were performed to obese subjects. Relationship between adropin levels and blood pressure variables were examined.
Results: Serum adropin levels were significantly lower in obese subjects than healthy controls (193.56±94 vs 289±187 pg/ml, P=0.03). Adropin levels were correlated negatively with BMI z-score (r=−0.56, P=0.034). There were no correlation between serum adropin levels and laboratory data in obese subjects. Five of the patients (12.5%) were non-dipper, nine of the patients (22.5%) had hypertension. There were no significant correlation between serum adropin levels and blood pressure data.
Conclusion: Serum adropin levels were significantly lower in obese children, however there were no correlation between serum adropin levels and blood pressure variables. Further studies are needed to determine the role of adipokines on blood pressure.
01 - 03 Oct 2015
European Society for Paediatric Endocrinology