Background: Simple obese is a worldwide public health problem. Recent studies suggested a possible relationship between obese and vitamin D deficiency.
Objective and hypotheses: To discuss the relationship between 25-Hdroxyvitamin D with glucose and lipid metabolism of simple obese in Chinese children.
Method: 65 children with obeses (35 mild-to-moderate, 50 severe) and sixty-two children with normal weight were enrolled in this trial. The Serum 25-hdroxyvitamin D, insulin, cortisol and C peptide were measured by CLIA.
Result: There was significant difference between obeses and normal children in serum 25-(OH) D (P<0.001). Serum 25-(OH) D was inversely related with BMI (r=−0.456, P<0.001), BMI SDS (r=−0.447, P<0.001). Serum 25-(OH) D was inversely related with triglyceride obsess children (r=−0.389, P<0.001). Moreover, triglyceride in obese children with serum 25-(OH) D≤50 nmol/l was higher than that in obese children with 25-(OH) D>50 nmol/l (P<0.05). Serum 25-(OH) D was not statistically significant with blood total cholesterol and low density lipoprotein cholesterol (hdl-c), blood glucose, insulin, haemoglobin A1c in obese children (P>0.05).
Conclusion: Serum 25-(OH) D in obese children are lower than normal weight children, Serum 25-(OH) D was inversely related with height and BMISDS, 25-(OH) D was inversely related with triglyceride level in obeses, which imply that 25-(OH) D maybe a risk factor of obesity and abnormal blood lipid.
01 - 03 Oct 2015
European Society for Paediatric Endocrinology