Background: Recent years bring a lot of data of the important role of vitamin D in different physiological processes, including a prevention from pathological states.
Objective and hypotheses: The aim of the study was to analyze associations between serum level of vitamin D and some markers of glucose and lipid metabolism but also as well bone-related molecules as adipokines and in children and adolescents.
Method: 57 patients, 40 with type 1 diabetes mellitus (T1DM), 17 with obesity, and 11 control, healthy age- and BMI-matched children were included in the study. Fasting blood samples for measurement of vitamin D, lipid profile, glucose, HbA1c concentrations, but also as well bone derived sclerostin, osteocalcin (OC) and Receptor Activator of Nuclear Factor NF-κB ligand (RANKL), as fat tissue-derived leptin and adiponectin were taken at 0800 h. Vitamin D was measured by HPLC, hormones by immunochemistry, and other parameters by routine chemistry methods. Statistical analysis was performed in all groups using ANOVA with post-hoc Turkey test and multiple regression analysis.
Results: Vitamin D levels did not differ among three groups: patients with T1DM, obese patients, and healthy ones. There were significant differences regarding C-peptide, HbA1c, fasting glucose, leptin, LDL-cholesterol, HDL-cholesterol, HDL-cholesterol/total cholesterol levels among groups P<0.001. In multiple regression analysis vitamin D was negatively related to HOMA index in obese children (p=0.01). The partial regression coefficient of vitamin D for HOMA-IR was strong (r=−0.64). In the group of patients with T1DM vitamin D correlated negatively with HbA1c (r=−0.3, P=0.03). In the control group vitamin D was positively related to OC (P=0.028).
Conclusion: The results of our study suggest that vitamin D could influence energy metabolism in children and adolescents. Its action seems to be associated with as well insulin action as with bone-derived OC.
Funding: This study was supported by a grant nr K/ZDS/001812, from Medical College, Jagiellonian University in Cracow.
01 - 03 Oct 2015
European Society for Paediatric Endocrinology