ESPE Abstracts

Background: Type 1 Diabetes Mellitus children are at risk to suffer from thyroid dysfunction. The association between thyroid stimulating hormone and hemoglobin A1c is still controversy.

Objective: To determine the association between thyroid stimulating hormone and hemoglobin A1c in type 1 Diabetes Mellitus children.

Methods: We conducted a cross sectional study from January - June 2017 in pediatric endocrine outpatient clinic dr Soetomo Hospital. Subjects were Type 1 DM children aged 7 until <18 years old. Exclusion criterias were diabetes ketoasidosis, previously diagnosed thyroid problems and patients hospitalized in PICU.

Results: 34 patients included in the study. Nineteen (54.3%) were male, mean of age was 11.3 years old. Mean of duration of diabetes was 3 years, mean of thyroid stimulating hormone was 3.76 mIU/l. The lowest was 0.033 mlU/l and highest 45,300 mlU/l. There were 2 male patients with high TSH level, 25 and 45 mIU/l respectively. These patients then follow up for FT4 and we have normal FT4. So we diagnose patients as subclinical hypothyroidism. The association of duration of diabetes and Thyroid stimulating hormone was r_s=−0.068; P=0.703 (P>0.05). The association of thyroid stimulating hormone and hemoglobin A1c was r_s=−0.017; P=0,925 (P>0,05).

Conclusion: There was not any association between thyroid stimulating hormone and hemoglobin A1c in T1DM children.

Keywords: thyroid stimulating hormone, hemoglobin A1c, type 1 diabetes mellitus children.