ESPE Abstracts (2018) 89 P-P3-297

Is Premature Adrenarch Associated with Precocıous Puberty via Kisspeptin?

Aysun Albayrak, Gul Direk, Zeynep Uzan Tatlı, Merve Nur Hepokur, Leyla Akın, Nihal Hatipoğlu, Mustafa Kendirci & Selim Kurtoğlu

Erciyes University Department of Pediatric Endocrinology, Kayseri, Turkey

Aim: Premature pubarche is defined as the start of axillary and pubic hair before age 9 in boys and 8 in girls. 10 times more common in girls than boys. Central precocious puberty is a condition due to early activation of hypothalamic-pituitary- gonadal axis associated with breast development before age 8 in girls and testicular volume growth before age 9 in boys. Despite this axle is not known exactly which hormones are respnsible for the activation, the role of kisspeptin’s role as a trigger factor has been demonstrated in many studies. The aim of this study is to evaluate activation of kisspeptin which is the first hormon level known tor ise.

Method: Girls with <8 yeras of age were enrolled in our study. 17 patients diagnosed with prematüre pubarche, 20 patients diagnosed with central precocious puberty and admitted to the general pediatrics clinic reasons nonendocrine, 20 healty age- matched girls were divided into groups as the control group. Each group of basal LH,FSH, E2 and were adrenal androgens. LHRH test was administered to patients. Kisspeptin levels were studied from all patients in the study.

Results: Plasma kisspeptin level central puberty precocious puberty group (122.1±51 pg/ml) in premature pubarch to (209.4±56 pg/ml) by statistically significant difference was observed (P<0.001). Premature pubarche group with in the control group (143±51 pg/ml) showed a significant difference (P<0.001). estrogen levels were negatively correlated with kisspeptin. In the group of central precocious puberty peak LH/FSH ratio and kisspeptin was a positive correlation between levels.

Discussion: The mean value of estrogen in central puberty precocious group was significantly higher than the other groups, and the high estrogen levels may be responsible for the decreased level of kisspeptin. The possitive correlation between peak LH/FSH ratio and kisspeptin levels shows the importance of Kisspeptin/GPR54 signaling system for onset of puberty.

Keywords: central precocious puberty, premature adrenarch, kisspeptin

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