hrp0089p3-p265 | Multisystem Endocrine Disorders P3 | ESPE2018

Insulinoma as Initial Presentation of Multiple Endocrine Neoplasia Type 1

Borowiec Ada , Kucharska Anna , Pyrżak Beata

Background: Multiple Endocrine Neoplasia type 1 (MEN1) is a disorder with autosomal dominant inheritance pattern. It is characterized by the occurance of parathyroid, pituitary and pancreatic tumors. MEN1 presented by insulinoma as first presentation in children is very rare. On the other hand insulinoma affects 10% patients with MEN1 and occurs usually in young patients.Case: Eleven years and eight months old girl was admitted, after a syncopal episode ...

hrp0095t16 | Section | ESPE2022

The Relationship Between Leptin, Kisspeptin, Irisin, Myostatin and Omentin Levels and Fat Tissue at Puberty

Başak Polat Zeliha , Orbak Zerrin , Doneray Hakan , Ozturk Nurinnisa

Introduction: The hypothalamo-pituitary system is activated as puberty begins and GnRH release occurs as well as the synthesis of many hormones. These hormones cause changes on muscle development, body fat distribution. In this study, changes in miyostatin, irisin, kisspeptin, omentin and leptin levels and the relationship of these changes with physical properties and fat tissue were investigated.Material and Method: A t...

hrp0086p2-p55 | Adrenal P2 | ESPE2016

The Treatment of a Functional Adrenocortical Cancer with Mitotane

Kurtoglu Selim , Hatipoglu Nihal , Gul Ulku , Tatlı Zeynep Uzan , Akın Leyla , Kendirci Mustafa

Introduction: In the pediatric age group, the incidence of the adrenocortical cancer (ACC) is 0.2%. The effective treatment is surgical resection. The only medical option is mitotane but it has negative effects on steroidogenesis. The difficulty in the management of mitotane therapy is discussed in this case.Case report: An 1110/12 years-old boy was referred with A 5 cm diameter solid-hypoecoic mass observed by sonography in the left surrenal ...

hrp0092lb-2 | Late Breaking Posters | ESPE2019

The Effects of Different Diets (High Fat and High Fructose Diet) on the Development of Insulin Resistance and Tissue Advanced Glycation End Product Levels in Rats

Demirci Tuba , Orbak Zerrin , Ozturk Nurinnisa , Kaygisiz Merve Durmus , Nalci Kemal Alp , Polat Zeliha Başak

Introduction & Objectives: Fat and fructose-rich nutrition bring many metabolic diseases, especially obesity and diabetes. Recent years, more scientific interest in how can diet effect on brain function has emerged. We aimed to investigate the effect of high fructose and high-fat diet on the brain, and whether the presence of relationship with advanced glycation end products histologically, in rat model.Materials & Method...

hrp0089p1-p055 | Diabetes & Insulin P1 | ESPE2018

Wolfram Syndrome Case with Hypergonadotropic Hypogonadism: A Novel Mutation

Uzan Tatlı Zeynep , Direk Gul , Hepokur Mervenur , Hatipoglu Nihal , Akın Leyla , Kendirci Mustafa , Kurtoglu Selim

Introduction: A rare cause of diabetes mellitus is Wolfram Syndrome, which arises from mutations in wolframin gene found on chromosome 4. Optic nerve atrophy, diabetes insipidus, sensorineural deafness, psychiatric problems can accompany diabetes mellitus, so it can be also named as DIDMOAD syndrome. Hypergonadotrophic hypogonadism can be rarely observed in Wolfram syndrome. A case of novel homozygous mutation in the wolframin gene has been reported because of concomitant rare...

hrp0089p3-p124 | Diabetes & Insulin P3 | ESPE2018

Continuous Glucose Monitoring Results of Our Cases with MODY Type 2 Diabetes

Tatlı Zeynep Uzan , Direk Gul , Hepokur Mervenur , Hatipoğlu Nihal , Akın Leyla , Kendirci Mustafa , Kurtoglu Selim

Introduction: The most common type of diabetes in childhood is type-1 diabetes. The group of diabetes called MODY (maturity-onset diabetes of the young) is rarer. Mutations that occur in glucokinase gene cause disruption in the perception of the resultant glucose level and, consequently, impaired insulin release, leading to the development of MODY-2. In this case, resulting hyperglycemia is usually at a mild, non-progressive level and does not require insulin therapy. For this...

hrp0086p2-p318 | Diabetes P2 | ESPE2016

A Rare Reason of Type 2 Diabetes: Alström Syndrome

Akın Onur , Ozge Gokhan , Sarı Erkan , Sarı Sinan , Unay Bulent , Yeşilkaya Ediz

Background: Alström Syndrome (ALMS), occurred due to mutations in ALMS1 gene, is a rare otosomal ressesive disorder. Seven hundred cases have been reported so far. Main clinical findings are rod con dystrofy, neurosensorial deafness, obesity and type 2 diabetes. Hypogonadism, hypothyroidism, growth hormone deficiency, hipertryglyceridemia, cognitive dysfunction, cardiomyopathy, renal, hepatic and pulmoner disorders could also be seen.Objective and h...

hrp0089p3-p094 | Diabetes & Insulin P3 | ESPE2018

Our Clinical Experiences in Type 2 Diabetes

Direk Gul , Uzan Tatlı Zeynep , Nur Hepokur Merve , Gul Şiraz Ulku , Akın Leyla , Hatipoğlu Nihal , Kendirci Mustafa , Kurtoğlu Selim

Background: Type 2 diabetes is a heterogeneous disorder characterized by the defective of insulin, which can not progressively compensate for insulin resistance, due to the influence of environmental factors on the basis of genetic susceptibility. Hyperglycemia, which starts with insulin resistance, is thought to show toxic effects (glucotoxicity) on β cells and ultimately impairs beta cell function., Although many factors play a role in etiology, obesity is the most comm...

hrp0089p2-p130 | Fat, Metabolism and Obesity P2 | ESPE2018

A Rare Case of Diabetes Mellitus in an Adolescent: Partial Lipodystrophy

Ozen Samim , Ata Aysun , Gokşen Damla , Akıncı Barış , Tuncer Canan Altay , Darcan Şukran

Introduction: Lipodystrophies are heterogeneous group of disorders; characterized by congenital or acquired loss of fat tissue. These disorders can causes severe metabolic complications during childhood. Case: 10.5 years old girl admitted to our clinic due to pigmented lesions on her body. She was investigated due to sclerotic lesions on her legs when she was 8 years old and was diagnosed as scleroderma and methotrexate was initiated. On physical examination weight was 47 kg (...

hrp0089p3-p247 | Growth & Syndromes P3 | ESPE2018

A Rare Chromosomal Disorder, Trisomy 4p

Hepokur Merve Nur , Tatlı Zeynep Uzan , Direk Gul , Akın Leyla , Hatipoğlu Nihal , Kendirci Mustafa , Kurtoğlu Selim

Background: 4p duplication syndrome is a very rare chromosomal disorder. In the literature; dysmorphic facial features, learning disability, speech retardation, overgrowth, musculoskeletal abnormalities, attention deficit hyperactivity disorder and autism syndrome have been reported to be associated with 4p16.3 duplication. Here we present a patient who admitted to our clinic with complaints of growth in hands and feet along with delayed speech and mental retardation. The gene...