ESPE Abstracts

Objective: The aim here was to describe the characteristics of obese children and adolescents and to determine how the prevalence of comorbidities differed over 10 years in China.

Methods: Obese children and adolescents were enrolled from Department of Endocrinology, Children’s Hospital of Zhejiang University School of Medicine in Hangzhou (Zhejiang Province, China). Eligibility was defined by a body mass index (BMI) of ≥95^th percentile. Medical and physical assessments were obtained.

Results: 2916 participants (1954 boys and 962 girls) aged 10.5±2.6years undertook assessment during the recruitment period from January 2008 to December 2017. Average BMI standard deviation score was 3.39 (95%CI range 3.33-3.44). The majority of participants were found with obese related comorbidities, including 1453(49.9%) dyslipidaemia, 968 (33.3%) hypertension, 1733（60.4%）abnormal liver function, 1678 (57.6%) NAFLD, 1980 (69.3%) acanthosis nigricans, 996 (34.3%)abnormal glycaemia and 85 (2.9%)Type 2 Diabetes Mellitus. The prevalence of comorbidities has increased significantly over the 10 years in two age groups. The incidence of hypertension has almost doubled from year (2008–2012) to year (2013–2017) in both sex groups aged<10 years and girl group aged >10 years.

Conclusions: Our study reveals that a high prevalence of metabolic dysfunctions among children and adolescents with obesity in China over 10 years, especially hypertension, NAFLD and abnormal glucose metabolism, which indicates the undiagnosed metabolic problems encountered by obese children and adolescents in China, and they should be focused on during subsequent follow-up, especially hypertension.