ESPE2021 ePoster Category 1 Fat, Metabolism and Obesity A (10 abstracts)
The possible association of the apoptotic marker APO1/Fas with predisposition to metabolic syndrome and mean platelet volume in children
Eirini Kostopoulou 1 , Maria Efthymia Katsa 2 , Maria Magana 2 , Anastasios Ioannidis 2 , Stylianos Chatzipanagiotou 3 , Athanasios Sachlas 4 , Bessie Spiliotis 1 & Andrea Paola Rojas Gil 2
1Division of Paediatric Endocrinology and Diabetes, Department of Paediatrics, University of Patras School of Medicine, Patras, Greece, Patras, Greece; 2Laboratory of Biology and Biochemistry, Faculty of Health Sciences, Department of Nursing, University of Peloponnese, Tripoli, Greece, Tripoli, Greece; 3Kapodistrian University of Athens Medical School, Aeginition Hospital, Department of Biopathology and Clinical Microbiology, Athens, Greece, Athens, Greece; 4Department of Statistics and Insurance Science, Faculty of Finance and Statistics, University of Piraeus, Athens, Greece, Athens, Greece
Objective: To investigate the possible relationship between APO1/Fas, components of metabolic syndrome and Mean Platelet Volume (MPV) in a healthy pediatric population.
Study design: 185 children, aged 5-17 years old, were enrolled to the study. The participants were divided intο subgroups according to age and body mass index percentile (BMI%). APO1/Fas was measured by ELISA and MPV by the MEK-6410K.
Results: Eighty-one children (43.8%) had excess weight (overweight: 27.5%, obesity: 16.2%), which was more prevalent in children ≤9 years of age. Sixty-five children (35.1%) exhibited a predisposition to metabolic syndrome. A negative correlation was found between APO1/Fas and predisposing factors for metabolic syndrome, such as weight, glucose, cholesterol, uric acid, LDL, triglycerides and CADi. In contrast, a positive correlation was found between APO1/Fas and CRP. ROC analysis showed a predisposition to metabolic syndrome when APO1/Fas was<78,46ng/ml. A negative correlation was also observed between APO1/Fas and MPV. Furthermore, increased BMI was positively correlated with uric acid, triglyceride concentrations, CADi, SGPT and GGT.
Conclusion: APO1/Fas expression may possibly have a protective role against metabolic syndrome in the paediatric population, through its involvement in angiogenesis, atherosclerosis and increased platelet activity, as expressed by elevated MPV. It may also enhance CRP-mediated protection of cells from necrotic lysis. Finally, close monitoring of all the components of metabolic syndrome in children with excess weight is important from a young age in order to prevent metabolic and cardiovascular complications.
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