ESPE2021 ePoster Category 2 Adrenals and HPA Axis (57 abstracts)
Endocrine-disrupting chemicals: an often-forgotten etiology of endocrinological disturbances
Ana Pereira Lemos 1,2 , Mariana Duarte 1 , Júlia Galhardo 1 & Lurdes Lopes 1
1Paediatric Endocrinology Unit, Hospital de Dona Estefânia – Central Lisbon University and Hospital Centre, Lisbon, Portugal; 2Paediatric Service, Leiria Hospital Centre, Leiria, Portugal
Background: Endocrine disruptors (ED) are chemicals that can mimic hormones and interfere with their receptors, causing endocrinological abnormalities.
Clinical report: We present the case of a previously healthy, melanodermic, two-year-old female, who had a three-month evolution of clitoromegaly and generalized hypertrichosis. Endocrine blood work showed suppressed serum androgens suggesting steroid exogenous contact. Karyotype, bone age, growth rate, and head and pelvic imaging exams were unremarkable. Detailed medical history revealed exposure to cyclosiloxanes and parabens within an anti-frizz hair product. She totally recovered during the 16 months after its withdrawal.
Discussion: ED have become a matter of concern over the past few years, due to its significant impact on public health, even in low doses. However, besides worldwide regulatory efforts, there are still several known ED in commonly used products, and also others that are not even listed on its labels. Therefore, strict rules should be put on urgently.
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