ESPE2023 Poster Category 1 Fat, Metabolism and Obesity (97 abstracts)
Risk Factors for becoming adult with obesity in survivors of childhoodcancer
Laurene Delacourt 1,2 , Rodrigue Allodji 3,4,5 , Juliette Chappat 3 , Nadia Haddy 3,4,5 , Chiraz El-Fayech 6 , Charlotte Demoor-Goldschmidt 3,7,8 , Neige Journy 3,4,5 , Stephanie Bolle 9 , Cécile Thomas-Teinturier 4,2 , Monia Zidane 3,4,5 , Carole Rubino 3,4,5 , Cristina Veres 3,4,5 , Giao Vu-Bezin 3,4,5 , Delphine Berchery 10 , Claire Pluchart 11 , Pierre-Yves Bondiau 12 , Agnès Dumas 13 , Nicolas Bougas 13 , Jacques Grill 6,14 , Christelle Dufour 6 , Brice Fresneau 4,5,6 , Helene Pacquement 1 , Ibrahima Diallo 3,15 , François Doz 1,13 & Florent De Vathaire 3,4,5
1SIREDO Center (Care, Innovation, Research in Pediatric, Adolescent and Young Adult Oncology), Institut Curie, Paris, France. 2Department of Pediatric Endocrinology and Diabetes AP-HP, Le Kremlin Bicêtre, France. 3Radiation Epidemiology Team, CESP, Inserm U1018, Villejuif, F-94805, France. 4Université Paris-Saclay, UVSQ, Inserm, CESP, Villejuif, F-94805, France. 5Department of Research, Gustave Roussy, Villejuif, F-94805, France. 6Department of Pediatric Oncology, Gustave Roussy, Gustave Roussy, F-94805, France. 7Department of Pediatric Oncology, University Hospital of Angers, Angers, F- 49000, France. 8Department of Radiation Therapy, Centre François Baclesse, Caen, France. 9Department of Radiation Therapy, Gustave Roussy, F-94805, France. 10Epidemiology Unit, Claudius Regaud Institute, Toulouse, F-31000, France. 11Pediatric Oncology, Centre Hospitalier Universitaire, Reims, F-51100, France. 12Radiation Therapy, Antoine Lacassagne Cancer Center, Nice, France. 13Université Paris Cité, Paris, France. 14Inserm U981, Villejuif, F-94805, France. 15Inserm U1030, Villejuif, F-94805, France
Purpose: The aim of this study was to identify risk factors for adult obesity in childhood solid cancer or lymphoma survivors (CCS).
Patients and Methods: The study included 3199 patients of the French Childhood Cancer Survivor Study Cohort (FCCS) with 303 obese patients who had returned self-questionnaire. Analyses were adjusted on social deprivation index and sex.
Results: CCS being less frequently obese (9.5%, 95% confidence interval [CI] 8.5% to 10.5%) than expected from the GFP rates (12.5%; P= 0.0001). Nevertheless, brain tumor survivors were significantly more obese than the GFP (P= 0.0001). Compared with patients who did not receive radiotherapy, for those who received < 1, 1 to 5, 5 to 20, 20 to 40, or ≥ 40 Gy of radiation to the pituitary gland, the RR of obesity was 0.8 (95% CI 0.5 to 1.1), 1.1 (95% CI 0.6 to 1.8), 1.09 (95% CI 1.2 to 3.1), 2.5 (95% CI 1.7 to 3.7), and 2.6 (95% CI 1.6 to 4.3), respectively. Etoposide administration appeared to significantly increase the risk of obesity (RR 1.7, 95% CI 1.1 to 2.6). High social deprivation index was also a risk factors for adult obesity, just like BMI at diagnosis.
Conclusion: Long-term follow-up of CCS should include weight follow-up during adulthood, especially in patients who had received pituitary gland irradiation.
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