ESPE Abstracts (2023) 97 P1-257

1SIREDO Center (Care, Innovation, Research in Pediatric, Adolescent and Young Adult Oncology), Institut Curie, Paris, France. 2Department of Pediatric Endocrinology and Diabetes AP-HP, Le Kremlin Bicêtre, France. 3Radiation Epidemiology Team, CESP, Inserm U1018, Villejuif, F-94805, France. 4Université Paris-Saclay, UVSQ, Inserm, CESP, Villejuif, F-94805, France. 5Department of Research, Gustave Roussy, Villejuif, F-94805, France. 6Department of Pediatric Oncology, Gustave Roussy, Gustave Roussy, F-94805, France. 7Department of Pediatric Oncology, University Hospital of Angers, Angers, F- 49000, France. 8Department of Radiation Therapy, Centre François Baclesse, Caen, France. 9Department of Radiation Therapy, Gustave Roussy, F-94805, France. 10Epidemiology Unit, Claudius Regaud Institute, Toulouse, F-31000, France. 11Pediatric Oncology, Centre Hospitalier Universitaire, Reims, F-51100, France. 12Radiation Therapy, Antoine Lacassagne Cancer Center, Nice, France. 13Université Paris Cité, Paris, France. 14Inserm U981, Villejuif, F-94805, France. 15Inserm U1030, Villejuif, F-94805, France

Purpose: The aim of this study was to identify risk factors for adult obesity in childhood solid cancer or lymphoma survivors (CCS).

Patients and Methods: The study included 3199 patients of the French Childhood Cancer Survivor Study Cohort (FCCS) with 303 obese patients who had returned self-questionnaire. Analyses were adjusted on social deprivation index and sex.

Results: CCS being less frequently obese (9.5%, 95% confidence interval [CI] 8.5% to 10.5%) than expected from the GFP rates (12.5%; P= 0.0001). Nevertheless, brain tumor survivors were significantly more obese than the GFP (P= 0.0001). Compared with patients who did not receive radiotherapy, for those who received < 1, 1 to 5, 5 to 20, 20 to 40, or ≥ 40 Gy of radiation to the pituitary gland, the RR of obesity was 0.8 (95% CI 0.5 to 1.1), 1.1 (95% CI 0.6 to 1.8), 1.09 (95% CI 1.2 to 3.1), 2.5 (95% CI 1.7 to 3.7), and 2.6 (95% CI 1.6 to 4.3), respectively. Etoposide administration appeared to significantly increase the risk of obesity (RR 1.7, 95% CI 1.1 to 2.6). High social deprivation index was also a risk factors for adult obesity, just like BMI at diagnosis.

Conclusion: Long-term follow-up of CCS should include weight follow-up during adulthood, especially in patients who had received pituitary gland irradiation.

Volume 97

61st Annual ESPE (ESPE 2023)

The Hague, Netherlands
21 Sep 2023 - 23 Sep 2023

European Society for Paediatric Endocrinology 

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