ESPE Abstracts

Background: Administration of recombinant GH (rhGH) to GH-deficient children has yielded conflicting results concerning its impact on thyroid function. Data about patients developing subclinical hypothyroidism are scanty, but it is thought to be associated with impairment of metabolic profile and lower growth response.Objective: To investigate the frequency of SH in children with pituitary dwarfism treated with rhGH, as well as its influence on rhGH ther...

Background: Children born small-for-gestational-age (SGA) have a birth weight below 2,500 g at a gestational age over 37 weeks or a birth weight or length below the 3-rd percentile for gestational age. They usually recover growth during the first 6–12 months of life, but if not so, it is unlikely the recovery to happen after the age of two unless GH replacement therapy is initiated.Objective: The aim of this study was to evaluate the 1-st year growt...

Background: Floating Harbor syndrome (FGS) is a dominant autosomal genetic disorder characterized by facial dysmorphism, delay in language development and short stature associated with delayed bone age. Currently there are about 100 cases reported worldwide. Although the short stature is one of the main features of the FHS, its etiology is poorly understood. A limited number of cases reported growth hormone deficiency as a cause of short stature in FHS and the evolution during...

Introduction: Following the onset of the COVID-19 pandemic in early spring 2020, there was a need to identify the burden of this infection on people with rare endocrine conditions. The European Registries For Rare Endocrine Conditions (EuRRECa) was launched in 2018 in collaboration with Endo-ERN, ESPE and ESE to support the needs of the wider endocrine community. The project consists of an e-reporting (e-REC) platform that allows monthly reporting of new clini...

Background: Clinical outcome data of patients with adrenal insufficiency, who were affected by COVID-19, have been collected as a common initiative by the ESE Rare Disease Committee and ENDO-ERN via the European Registries for Rare Endocrine Conditions (EuRRECa) project. Methods: This Webropol-based questionnaire included a total of 32 questions collecting quantitative and qualitative data. Of the 19 medical centres out ...

Introduction: Siberia traditionally belonged to iodine-deficient regions. Cessation of iodine prevention in the 1990-s promoted the increase of iodine deficiency disorders (IDD) in Siberia. For iodine prophylaxis now is used iodized salt, and iodine preparations.The Aim: To estimate the iodine deficiency, the prevalence of IDD and the effectiveness of iodine prophylaxis in the North of Krasnoyarsk territory.<p class=...

Introduction: There are the inconsistent data about a role cellular and humoral immunity in pathogenesis of type 1 diabetes mellitus.The aim: The aim of this research was to study features of the immune status and of the activity of metabolic enzymes in lymphocytes of blood in children with type 1 diabetes.Methods: Cellular and humoral immunity parameters were studied in 94 patient...

Background: young children with type 1 diabetes mellitus (DM1) have a tendency to recurrent hypoglycemia. Increased sensitivity to insulin in young diabetes patients may be associated with features of secretion of catecholamine, particularly adrenaline.The aim: to explore the basal levels of catecholamine (epinephrine, norepinephrine, and dopamine) in serum of young children with type 1 diabetes mellitus to identify of p...

Background: Mauriac's syndrome (MS) may occur in patients with poor controlled type 1 diabetes mellitus (DM1), with often ketoacidosis, episodes of hyperglycemia and hypoglycemia, under the dose insulin. MS characterized growth retardation and puberty delay, Cushingoid obesity, moon facies, protuberant abdomen, hepatomegaly with transaminase elevation, dyslipidemia. Now it is a rare syndrome, firstly described by Mauriac in 1930.<str...

Background: Prader-Willi syndrome (PWS) is a complex genetic disorder with implications on the endocrine and neurologic systems, metabolism, and behavior. Early in life, PWS is characterized by hypotonia and failure to thrive, followed by obesity and hyperphagia. Patients with PWS develop hypothalamic dysfunction which may lead growth hormone deficiency, hypogonadism, hypothyroidism, adrenal insufficiency and poor bone mineral density. Traditionally, obesity i...