ESPE Abstracts

Background: Neonatal diabetes mellitus (NDM) comprises a group of monogenic disorders caused by mutations in genes involved in pancreatic development or insulin secretion. Accurate and rapid molecular diagnosis of NDM is pivotal for making decision on the treatment strategy. Next-generation sequencing (NGS) allows simultaneos analysis of several candidate genes, which facilitates the diagnostic procedure in NDM.Objective and hypotheses: To summarise our ...

The gold standard for the treatment of Type 1 diabetes in children and adolescents is the intensified insulin therapy using either multiple daily injections (MDI) or continuous subcutaneous insulin infusion (CSII) pump according to the basal-bolus-principle. Blood glucose measurement is the mainstay of diabetes management, guiding insulin dosing decisions and monitoring glycemic control. New technological advances including subcutaneous continuous glucose monitoring (CGM), eit...

Global growth in the use of mobile phones, the so-called smartphones, makes them a powerful platform to help provide tailored health, delivered conveniently to patients. These devices are developing rapidly mainly with regard to information processing, design, features and connectivity with other devices. Modern treatment and monitoring of type 1 diabetes is being supported by rapid evolving technology as pumps for continuous subcutaneous insulin infusion and sensors for conti...

Background: The results of several studies suggest that vitamin D could possibly decrease the risk of autoimmune diseases.Objective: To evaluate the efficiency of the vitamin D in adolescents with Hashimoto’s thyroiditis (HT).Methods: The study included 32 adolescents (aged 12–17 years, mean age was 14.4±1.3 years) with HT (normal range TSH, fT3, fT4 and elevated antibodies). HT was diagnosed on...

Background: Self-monitoring of blood glucose is an essential tool in the optimal management of childhood and adolescent diabetes. In the last 15 years, an extraordinary development of reliable devices for real-time continuous glucose monitoring (CGM) has taken place. Meanwhile, several trials in adults and children showed that CGM can be associated with improved glycaemic control, significant reduction of hypoglycaemia and better quality of life, particularly in those patients...

Background: Congenital adiptical diabetes insipidus is rare condition in infancy. Immediate diagnosis and treatment is required to ensure normal development.Case report: A boy, from the 2nd pregnancy, 1st term delivery was born with weight 4480 g. Bottle feeding from the 1st months. Weight at 1st months – 4500 g, at 2nd – 5000 g. Until the first 2 months mother complained on child’s apathia, feeding problems, vomiting, weight stagnation. A...

Hyperglycemia in newborns is most common in premature infants. At present, in clinical practice, the attitude towards this type of metabolic disorders is not well defined and controversial.Objective: To determine the feasibility of prescribing insulin for hyperglycemia in premature newborns.Patients and Methods: We observed 68 newborns with a birth weight of 1326 ± 119.8 g and a gestational ag...

Background: Obesity is associated with increased risks of the disease of the reproductive organs (including breasts). Several studies mentioned correlation between obesity and increased risks for breast cancer.Objective and hypotheses: To study the frequency and peculiarities of breasts diseases in adolescent girls with obesity.Method: The study included 2369 adolescent girls (aged 11–19 years). Gils were subjected to the clin...

Background: Pendred’s syndrome (Pendred’s disease) is a genetic disorder leading to congenital bilateral sensorineural hearing loss and goitre with occasional hypothyroidism. Cause of Pendred’s syndrome is mutations in the SLC26A4 gene. The SLC26A4 gene provides instructions for making a protein called pendrin. The pendrin transports negatively charged ions (chloride, iodide, and bicarbonate) into and out of cells.Objective and hypotheses:...

It is noted that with gestational diabetes mellitus, lipids cross the placenta in a limited amount. It is assumed that their concentration in maternal blood correlates with the concentration of lipids in the fetus. The purpose of this study was to compare the levels of the main indicators of the lipid profile, such as cholesterol, triglycerides and high and low density lipoproteins, in newborns and similar indicators in their mothers with gestational diabetes.<p class="abs...