ESPE Abstracts

Objective: To define the prevalence of autoantibodies at presentation in children with type 1 diabetes and to determine the associated comorbid autoimmune conditions in Indian pediatric patients.Materials and Methods: Children (n=468) diagnosed with type 1 diabetes at Indraprastha Apollo Hospital, Delhi, India for childhood Diabetes were screened for autoimmune thyroid disease (thyroid peroxidase autoantibodies [TPOAb]), celiac disease (tissue t...

Introduction: Type 1 Diabetes is a condition associated with deficiency of insulin, which is a key regulator of carbohydrate and fat metabolism. Most newly diagnosed type 1 diabetes present with diabetic ketoacidosis, which is a triad of hyperglycemia, ketonemia and acidosis. It usually presents with features of acidosis such as lethargy, dehydration, and tachypnea.Case: We present a case that presented to us with a lipemic blood sample and on further wo...

Introduction: Liraglutide is a long-acting glucagon-like peptide-1 receptor agonist which directly stimulate POMC neurons and inhibit neuropeptide-Y and Agouti-related peptide neurons of the arcuate nucleus resulting in appetite suppression. It has been approved in adult population for obesity.Aim: To assess the Efficacy and Safety of Liraglutide in Indian Adolescent obese population.Materia...

Background: Obesity is one of the most common nutritional problems in developed countries. The prevalence of obesity is rapidly progressing in children. It is associated with serious health hazards in adolescence and especially in adulthood, like hypertension, coronary artery disease, diabetes mellitus, etc.Methods: A study was conducted including the pediatric patients presented to Indraprastha Apollo hospital with signs of insulin resistance. All patie...

Introduction: Congenital Hyperinsulinemic hypolglycemia (CHI) is a rare genetic disorder resulting severe hypoglycaemia secondary to excessive insulin release from the pancreatic cells. Its early diagnosis is imperative to prevent irreversible brain damage by hypoglycemia. Genetic testing and 18-F-DOPA scan help to confirm the diagnosis.Case: A 2.7 kg male baby was born at term to non-consanguineous parents by normal vaginal delivery. On day 4 of life th...

Objective: To evaluate the genetic mutations prevalent in Indian children with Neonatal diabetes.Methods: All infants, less than 6 months of age with hyperglycemia requiring insulin were included in the study and their genetic testing were done.Results: Ten infants with ND were included; there were three females and seven males. The age of presentation ranged from 4 weeks to 28 weeks of age. of all the children tested 5 children we...

Objective: To evaluate the growth response in children with Noonan syndrome (NS) treated with growth hormone (rGH).Methods: We retrospectively collected data from 2007 of pre-pubertal children with NS, their baseline auxological parameters were recorded pre and post treatment.Results: A total 1134 were treated with growth hormone for short stature of which there were six cases of NS, constituting 0.5% of the short stature. There we...

Introduction: Pallister Hall Syndrome (PHS) is a rare autosomal dominant disorder clinically diagnosed by hypothalamic hamartoma, mesoaxial or postaxial polydactyly, and can have several endocrine abnormalities associated with.Case: We report a case of a 7 year old boy presented with precocious puberty and short stature. He was the youngest of 11 siblings, who used to have laughing spells and global developmental delay till four years of age. He had an M...

Introduction: Thyroid hormone abnormalities are the commonest endocrine disorder in India and also the commonest preventable cause of mental retardation.Aim: To determine the prevalence, clinical profile, etiology and associated co-morbidities of thyroid dysfunction in children.Materials and Methods: This is a retrospective study, performed in our tertiary care Pediatric Endocrine Center at Indraprastha Apollo Hospital, Delhi, Indi...

Objective: To evaluate the prevalence of autoantibodies associated with hypothyroid disease and to assess the associated comorbid autoimmune diseases in Indian pediatric patients.Materials and Methods: Children (n=373) diagnosed with hypothyroidism at Indraprastha Apollo Hospital, Delhi, India were screened for celiac disease (tissue transglutaminase autoantibodies [TTGAb]) which were further confirmed by upper GI endoscopy and biopsy for coelia...