hrp0089p1-p252 | Thyroid P1 | ESPE2018

Morning Versus Bedtime Levothyroxine Administration: What is the Choice of Children?

Akin Onur

Aim: The present study compared the administration of levothyroxine (LT4) before breakfast and bedtime in school children diagnosed with hypothyroidism and analyzed the effects of timing on thyroid functioning and patient satisfaction.Methods: A total of 163 children with hypothyroidism (125 females and 38 males) between 8 and 18 years of age and taking LT4 for at least three months were enrolled in the study. The timing of administration of the drug of ...

hrp0089p2-p164 | Fat, Metabolism and Obesity P2 | ESPE2018

Comparison of Antropometric and Biochemical Parameters in Obese Children with or without Primary Headache

Akin Onur , Arslan Mutluay

Aim: The objective of our study was to investigate the physical examination and laboratory findings in obese children with or without primary headaches.Methods: A total of 161 children, aged 8-18, with obesity (90 female and 71 male) and primary headache, admitted to pediatric endocrinology and pediatric neurology department between 2013 and 2018 were evaluated retrospectively. Participants were divided into subgroups as with tension headache and migrain...

hrp0089p2-p278 | Growth & Syndromes P2 | ESPE2018

Effects of Inhaled Corticosteroids and Montelukast on Growth and BMI in Children with Asthma

Akin Onur , Yavuz Suleyman Tolga

Background: Inhaled corticosteroids (ICS) and montelukast are commonly prescribed drugs in asthma treatment. Several studies have investigated the adverse effects of ICS on growth and weight gain in children. However, the biosafety studies of montelukast are mostly focused on the neuropsychiatric side effects. The present study aimed at investigating the adverse effects of montelukast and ICS on anthropometric parameters in children.Methods: The present ...

hrp0082p3-d3-839 | Growth (2) | ESPE2014

A Rare Syndrome Benefits from GH Therapy: Hypotonia–Cystinuria Syndrome

Akin Onur , Hacihamdio[gbreve]lu Bulent , Ye[scedil]ilkaya Ediz

Background: Hypotonia–Cystinuria syndrome (HCS), characterized by hypotonia at birth, poor feeding and growth retardation is an autosomal recessive disorder caused by homozygous microdeletions of PREPL and SCL3A genes. Increase in the urinary amino acids including cystine, lysine, arginine, and ornithine is the main laboratory finding.Objective and hypotheses: HCS was described in 17 patients so far and previous reports with favorable responses to G...

hrp0084p2-231 | Bone | ESPE2015

Cinacalcet Treatment in Girls with Hereditary Vitamin D Resistant Rickets

Sari Erkan , Ozkececi Firat , Akin Onur , Bolat Ahmet , Yesilkaya Ediz

Background: HVDRR is characterised by hypocalcaemia, secondary hyperparathyroidism and severe early-onset rickets in infancy and is diagnosed easily especially associated with alopecia.Objective and hypotheses: Successful treatment requires reversal of hypocalcaemia and secondary hyperparathyroidism and is usually failed by high dose calcitriol but sometimes accomplished by administration of high doses calcium. Some patients need enteral or parenteral co...

hrp0084p3-635 | Autoimmune | ESPE2015

Radiologic Appearance is Important for Diagnosis of Autoimmune Hypophysitis

Sari Erkan , Yesilkaya Ediz , Akin Onur , Gursel Orhan , Sari Sebahattin

Background: Aetiologic causes should be evaluated in patients with central diabetes insipidus. Inflammatory and malign diseases must be exclude.Objective and hypotheses: A 9-year-old girl suffered from polyuria and polydipsia was diagnosed CDI. Adenohypohysis height and infudibulum thickness were increased 8 and 9 mm respectively. Physical findings were consistent with Tanner stage 1, height SDS −0.48, and BMI 91 percentile. Tumor markers and adeno...

hrp0086p2-p184 | Bone & Mineral Metabolism P2 | ESPE2016

DiGeorge Syndrome and 10p Deletion

Sari Erkan , Akar Hatice , Akin Onur , Zeybek Cengiz , Kozan Salih , Unay Bulent , Yesilkaya Ediz

Background: Hypoparathyroidism, deafness and renal dysplasia (HDR) syndrome is a rare condition inherited as an autosomal dominant trait. The responsible genetic defect is in the region 10p. Phenotype is very similar to DiGeorge Syndrome (DGS) which occurs due to 22q11 microdeletion.Method: An 8-year-old girl was referred to Pediatric Endocrinology outpatient department because of hypoparathyroidism. She was born at 36 weeks after a normal pregnancy and ...

hrp0084p3-634 | Autoimmune | ESPE2015

Stevens Johnson Syndrome in a Case with Type 1 Diabetes Mellitus: Relation or Coincidence?

Akin Onur , Doger Esra , Demet Akbas Emine , Bakirtas Arzu , Camurdan Orhun , Bideci Aysun , Cinaz Peyami

Background: Stevens-Johnson syndrome (SJS) is an acute life-threatening dermatosis characterised by conjunctivitis, oral ulcerations, fever, and erythematous macules. The most important etiological factors are infections and drugs including anticonvulsants and nonsteroidal anti- inflammatories.Objective and hypotheses: Cases with both SJS and type 1 diabetes mellitus have been reported rarely in the literature. Herein, we report a diabetic case of recurr...

hrp0084p3-686 | Diabetes | ESPE2015

A Rare Reason of Hyperinsulinism: Münchausen Syndrome by Proxy

Yesilkaya Ediz , Akin Onur , Sari Erkan , Macit Enes , Akar Cagdas , Gun Husamettin

Background: Drug intoxication is one of the rare reasons of hyperinsulinism; it may occur not only accidentally but also deliberately.Objective and hypotheses: Herein, we report a case who presented with factitious hyperinsulinaemic hypoglycemia and diagnosed with Münchausen syndrome by proxy (MSBP) which is an uncommon condition of child abuse.Method: A 7-year-old girl was referred to our department due to hyperglycemic and h...

hrp0086p1-p249 | Diabetes P1 | ESPE2016

Autoimmune Limbic Encephalitis Associated with Type 1 Diabetes Mellitus

Kilinc Ugurlu Aylin , Doger Esra , Demet Akbas Emine , Akin Onur , Arhan Ebru , Bideci Aysun , Camurdan Orhun , Cinaz Peyami

Background: Limbic encephalitis (LE) is a neurological disorder characterized with amnesia, seizures, personality changes. LE is usually considered as paraneoplastic disorder. Infections, paraneoplastic disorders and autoimmunity should be considered in LE etiology. Association of type 1 diabetes mellitus and LE is very rare. Here in we report a patient who was diagnosed with type 1 diabetes mellitus (T1DM) six months after LE occurrence.Case: A 17-year-...