hrp0092p1-347 | Fat, Metabolism and Obesity (2) | ESPE2019

Precocious Pubarche in Spinal Muscular Atrophy Patients with Severe Sarcopenia

Brener Avivit , Lebenthal Yael , Shtamler Anna , Stein Ronnie , Fattal-Valevski Aviva , Sagi Liora

Context: Spinal muscular atrophy (SMA) is an autosomal recessive inherited disease characterized by degeneration of anterior horn cells of the spinal cord and brainstem resulting in variable degrees of muscular atrophy and proximal muscle weakness. In December 2016, nusinersen was FDA-approved for the treatment of SMA in pediatric and adult patients. The introduction of this therapeutic modality has provided a platform for professional medical-care providers i...

hrp0097rfc12.4 | Thyroid | ESPE2023

Polyethylene glycol thyroid stimulating hormone (PEG-TSH) in real-life: a practical tool for solving a biochemical dilemma

Zaitoon Hussein , Shefer Gabi , Segev-Becker Anat , Ayal Ori , Lebenthal Yael , Brener Avivit

Background: The polyethylene glycol (PEG) method, which utilizes the addition of PEG to precipitate immunoglobulin fractions in order to measure free thyroid stimulating hormone (TSH), has been implemented as a tool for investigating incongruities in TSH measurement.Aim of the study: To investigate the practical application of PEG-TSH testing in pediatric scenarios with a discrepancy between elevated TSH and normal free ...

hrp0092p2-6 | Adrenals and HPA Axis | ESPE2019

Corticosteroid Use: Practices and Attitudes of Pediatricians

Sekler Opal , Segev-Becker Anat , Interator Hagar , Brener Avivit , Schachter-Davidov Anita , Elkon-Tamir Erella , Lebenthal Yael

Context: Synthetic corticosteroids are medications frequently prescribed for a wide range of medical indications. Various preparations differ in their biological effect, mode of administration, potency and duration of action. Comprehensive knowledge is essential in order to prescribe corticosteroids in an efficient yet safe manner.Objectives: To explore pediatricians' practices and attitudes regarding corticosteroid ...

hrp0084p1-44 | Diabetes | ESPE2015

Is Metabolic Control Affected by Military Service in Young Adults with Type 1 Diabetes?

Brener Avivit , Mel Eran , Shalitin Shlomit , Lazar Liora , de Vries Liat , Tenebaum Ariel , Oron Tal , Philip Moshe , Lebenthal Yael

Background: Young adults with type 1 diabetes (T1D) are exempt from conscript military service due to risk of severe hypoglycaemia and metabolic compromise. Nevertheless, there are patients who volunteer to military service.Aims and objectives: To evaluate the effect of military service on metabolic control and incidence of acute diabetes complications.Methods: Study design: retrospective, comparative analysis. Data of 145 T1D pati...

hrp0094p2-201 | Fat, metabolism and obesity | ESPE2021

Weight status and body composition of children and adolescents during the COVID-19 pandemic

Brener Avivit , Azoulay Erez , Yackobovitch-Gavan Michal , Lopez Adar , Sheppes Tamar , Yaacov Hadar , Gilboa Inbar , Waksman Yarden , Lebenthal Yael ,

Background: The COVID-19 pandemic has tremendous effects on lifestyle that could potentially cause health-related problems. Therefore, extreme preventive measures were taken, including the closure of schools and after school activities. This dramatic alteration in daily routine could lead to adverse consequence of increasing obesity. In this study we aimed to investigate the change in weight status and body composition parameters of children and adolescents du...

hrp0097p1-588 | Thyroid | ESPE2023

The effect of gestational Graves’ disease on the mother-infant dyad: a retrospective observational cohort study

Cohen-Sela Eyal , Brener Avivit , Raviv Orian , Yackobovitch-Gavan Michal , Almashanu Shlomo , Marom Ronella , Anteby Matan , Hiersch Liran , Lebenthal Yael

Context: Pregnancy and parturition involve a complex interplay between maternal health and that of her offspring. Graves’ disease and its management have been associated with adverse pregnancy, labor and delivery, as well as neonatal outcomes. Adaptation of the hypothalamic-pituitary-thyroid axis can be reflected by measuring thyroid function levels in newborn screening (NBS).Objective: To investigate the character...

hrp0095p1-405 | Adrenals and HPA Axis | ESPE2022

Body composition in children and adolescents with non-classic congenital adrenal hyperplasia and risk for metabolic syndrome components – an observational study

Ben Simon Asaf , Brener Avivit , Segev-Becker Anat , Yackobovitch-Gavan Michal , Uretzky Adi , Schachter Davidov Anita , Oren Asaf , Eyal Ori , Lebenthal Yael

Context: Non-classic congenital adrenal hyperplasia (NCCAH) diagnosed in childhood, whether treated or untreated, could pose an increased risk of obesity and metabolic derangements in adolescence and early adulthood. Both sustained hyperandrogenism and chronic glucocorticoid therapy may affect body composition. However, little is known about the body composition of subjects with NCCAH and its contribution to the development of adverse metabolic outcomes. <...

hrp0095p1-449 | Diabetes and Insulin | ESPE2022

Do-It-Yourself Artificial Pancreas Systems in a PediatricPopulation with Type 1 Diabetes in a Real-life Setting: The AWeSoMe Study Group Experience

Nir Judith , Rachmiel Marianna , Fraser Abigail , Lebenthal Yael , Brener Avivit , Pinhas-Hamiel Orit , Haim Alon , Stern Eve , Levek Noa , Ben-Ari Tal , Landau Zohar

Aims: Do-It-Yourself Artificial Pancreas Systems (DIYAPS) represent a unique patient-initiated treatment in which commercially available and approved medical devices such as continuous glucose monitoring systems (CGMs) and insulin pumps are connected by an off-label algorithm, and are remotely controlled by open-source algorithms to automate insulin delivery. While these systems are co-created by the DIYAPS community, and access is open to everyone, users have...

hrp0095p1-368 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

Gender dimorphism in transgender youth – hormonal therapy and the balance between muscle, adipose tissue and cardiometabolic alterations

Borger Ophir , Oren Asaf , Perl Liat , Yackobovitch-Gavan Michal , Sheppes Tamar , Brener Avivit , Elkon-Tamir Erella , Israeli Galit , Segev-Becker Anat , Lebenthal Ophir Yael

Context: Given the importance of sex hormones in metabolic regulation, dynamics in body composition and cardiometabolic alterations may occur in transgender persons receiving gender-affirming hormone (GAH) therapy.Objectives: Our aim was to explore the association between muscle-to-fat ratio (MFR) and the risk for metabolic syndrome components in transgender youth.Methods: In 71 tr...

hrp0097rfc1.1 | Adrenals and HPA Axis | ESPE2023

Unfavorable Body Composition in Children with Premature Adrenarche: Implications for Metabolic Health

Ben Simon Asaf , Uretzky Adi , Yackobovitch-Gavan Michal , Segev-Becker Anat , Midlij Eyas , Borger Ophir , Laurian Irina , Dorfman Anna , Brener Avivit , Lebenthal Yael

Context: Premature adrenarche (PA) could pose an increased risk of obesity and metabolic derangements in adolescence and early adulthood. However, little is known about the body composition of children with PA and its association to the development of adverse metabolic outcomes.Aim: To describe the body composition of children with PA and explore the interaction between PA and metabolic syndrome components.<p class="...