ESPE Abstracts

Background: The clinical manifestations of McCune-Albright syndrome (MAS) are diverse, typically including fibrous dysplasia (FD), café au lait spots, and endocrine hyperfunction, most commonly gonadotropin-independent precocious puberty (GIPP). Management of endocrinopathies in MAS varies by the affected organs. Treatment options for GIPP include clinical observation, aromatase inhibitors (AIs), ketoconazole, medroxyprogesterone acetate, selective estr...

Background: Inflammatory markers in obesity with metabolic syndrome (MS) have been postulated to be associated with development of CVS diseases in adults.Objective: To study inflammatory marker levels in obese children.Method: A cross-sectional study of obese children was conducted. Children with history of endogenous obesity, chronic diseases, drug ingestion/any acute illnesses within two weeks prior to enrolment were excluded. Fa...

Background: Primary brain tumors are the most prevalent solid tumors among children. Both the tumor itself and therapeutic interventions can lead to endocrine complications and metabolic consequences in survivors. However, current information on these complications in childhood brain tumor survivors (CBTS) in Thailand is limited.Objectives: This study aims to evaluate the prevalence of endocrine and metabolic complicatio...

Background: Mutations in the ANKH gene affect the cellular transportation of the bone mineralization inhibitor, inorganic pyrophosphate (PPi). Loss-of-function mutations in this gene result in craniometaphyseal dysplasia (CMD), a rare disorder characterized by bone hyperostosis, particularly in the craniofacial bones, and metaphyseal widening of long bones. CMD patients experience impaired transport of PPi to extracellular compartment, leading to exce...

Background: Central precocious puberty (CPP) and early puberty (EP) are characterized by premature breast development. Girls with CPP and EP who experience rapid pubertal progression are treated with gonadotropin-releasing hormone analog (GnRHa) to halt pubertal advancement and optimize height potential. However, studies on factors impacting near-final height (NFH) for CPP and EP in Asian girls remain scarce. We aim ed to explore the factors associated with pr...

Background: Hyperglycemic ketoacidosis is an acute, life threatening condition requiring early etiologic recognition and management to prevent serious morbidity/mortality. The most common cause is diabetic ketoacidosis (DKA). Organic acidaemias (OAs) are inheritable metabolic disorders caused by defects in protein metabolism resulting in acid accumulation. Patients with metabolic decompensation usually present with lactic and/or ketoacidosis, with/without hypoglycemia. Hypergl...

Background: The incidence rate (IR) of childhood diabetes is increasing globally. These upward trends were also found in Thailand. However, newly diagnosed childhood diabetes incidences are not updated, especially in Northern Thailand. There are possibilities that COVID-19 pandemic affects the development of acute diabetes after infection and the severity of the first clinical presentation of childhood diabetes. However, data are also conflicting regarding the...

Background: Hyperthyroidism is a common condition in general pediatric practice. Several adult studies show hyperthyroidism affects health-related quality of life (HRQoL). However, information regarding HRQoL in the pediatric population is limited.Objectives: To evaluate HRQoL and psychosocial functioning of patients diagnosed with childhood primary hyperthyroidism compared with healthy controls and to identify the possi...

Background: Hypophosphatasia (HPP) is a rare inherited disease of bone metabolism caused by inactivating mutations in the ALPL gene encoding tissue non-specific alkaline phosphatase (TNSAP). Infantile HPP is characterized by early onset abnormal skeletal mineralization with hypercalcemia and low alkaline phosphatase (ALP). It has been rarely reported from Thailand, resulting in limited disease awareness. We reported an infantile HPP Thai patient who p...