hrp0086p2-p66 | Adrenal P2 | ESPE2016

Clinical-Laboratory Findings of the Cases with Premature Pubarche and the Value of Acth Stimulation Test in the Differential Siagnosis

Dilek Emine , Tutunculer Filiz , Bezen Digdem , Sut Necdet

Background: Premature pubarche is a diagnosis of exclusion, and it is a benign period. Non-classic congenital adrenal hyperplasia (NC-CAH) is one of the most important causes in the differential diagnosis of premature pubarche.Objective and hypotheses: In this study it was aimed to evaluate the clinical and laboratory data, of 75 cases (five male, 70 female) diagnosed as premature pubarche. Additionally basal 17-hydroxyprogesterone levels determined as N...

hrp0086p2-p307 | Diabetes P2 | ESPE2016

Evaluation of Autoimmune Thyroiditis Development on Onset and During Follow Up in Cases with Type 1 Diabetes Mellitus

Bay Bade , Tutunculer Filiz , Bezen Digdem , Dilek Emine , Ekuklu Galip

Background: Type 1 diabetes mellitus (T1DM) is the most common endocrine disease in children and adolescents.Objective and hypotheses: It was aimed to evaluate the frequency of autoimmune thyroiditis (AT) and the possible risk factors for AT at diagnosis and at follow up of T1DM patients.Method: T1DM patients who were admitted to Trakya University Medical Faculty Pediatric Department, Pediatric Endocrinology Outpatient Clinic betwe...

hrp0086p2-p720 | Endocrinology and Multisystemic Diseases P2 | ESPE2016

Familial Williams Syndrome

Isguven Sukriye Pinar , Aydin Dilek Bingol , Karkucak Mutlu

Background: Williams Syndrome (WS) is a multisystemic genetic syndrome, which includes characteristic appearance of “elfian face”, growth retardation, mild mental retardation, hypersociality, infantile hypercalcemia, and other endocrine, cardiovascular, and urinary abnormalities. WS is caused by the microdeletion of chromosome 7q11.23; it is usually sporadic but rare autosomal dominant familial cases have been reported in the literature. We present a boy and his moth...

hrp0086p1-p918 | Thyroid P1 | ESPE2016

Thyroid Autoimmunity and Vitamin D Status in Euthyroid Girls with Hashimoto’s Thyroiditis

Isguven Sukriye Pinar , Aydin Dilek Bingol , Kilic Mukaddes

Background: Hashimoto thyroiditis (HT) is the most common autoimmune disorder. There are few studies that analysed the relationship between HT and serum vitamin D.Objective and hypotheses: It has been suggested that vitamin D acts as an immunomodulator in autoimmune diseases such as HT Therefore we planned to investigate vitamin D status in euthyroid girls with HT.Method: The study group consisted of 66 euthyroid pubertal girls rec...

hrp0095p2-93 | Fat, Metabolism and Obesity | ESPE2022

The Relationship Between Serum AMH Levels and Puberty in Obese Girls

Sarikaya Emre , Cicek Dilek , Gok Ebru , Kara Leyla , Gul Siraz Ulku , Hatipoglu Nihal

Objectives: Anti-Müllerian hormone (AMH) is produced by Sertoli cells in the testicles and granulosa cells in the ovaries. Increased abdominal adipose tissue initiates metabolic and endocrine disorders and predisposes to polycystic ovary syndrome. AMH is used as a marker in PCOS. A decrease in AMH levels has been reported in adults with obesity and increased central adiposity. The purpose of this study was to assess the serum AMH level and related factors...

hrp0089p3-p090 | Diabetes & Insulin P3 | ESPE2018

Clinical and Laboratory Features at the Onset of Childhood Type 1 Diabetes Mellitus in the Nortwest Region (Trakya) of Turkey

Dilek Emine , Bezen Digdem , Ozguc Comlek Fatma , Ozkaya Beyhan , Tutunculer Filiz

Aim: To describe the clinical pattern and laboratory characteristics at presentation of a group of children with type 1 diabetes mellitus living in the Northwest region (Trakya) of Turkey.Methods: The clinical and laboratory data of a total of 315 children who presented with newly diagnosed type 1 diabetes mellitus during a 12 year period (2006–2018) were retrospectively analyzed based on hospital records. The data were assessed by gender and age su...

hrp0089p3-p226 | Growth & Syndromes P3 | ESPE2018

Etiologies of Short Stature in Pedaitric Endocrine Clinic in Northwest Region (Trakya) of Turkey

Ozkaya Beyhan , Dilek Emine , Bezen Diğdem , Ozguc Comlek Fatma , Tutunculer Filiz

Backround: Short stature (SS) is one of the common disorders referred for investigation of an endocrine disorder. The etiologies of SS vary and are commonly grouped into pathological and nonpathological disorders. Despite standard clinical and laboratory evaluation, a pathological diagnosis is not reached in 50–90% cases.Aim: The aim of this study was to determine the etiologies and decribe the characteristic of short stature patients who were follo...

hrp0089p3-p295 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Does Acquired Hypothyroidism Lead to Precocious Puberty?

Aydın Dilek , İşguven Pınar , Aydın Engin

Introduction: Hypothyroidism without treatment usually leads to delayed puberty in pediatric patients, sometimes it may rarely lead Van Wyk Grumbach syndrome (VWGS) which is characterized by isosexual precocious puberty. Exact mechanism of VWSG is unknown. High thyroid stimulating hormone (TSH) levels may directly effect on follicular stimulating hormone (FSH) receptors and lead precocious puberty. Interestingly simple thyroid hormone replacement therapy resolves symptoms in t...

hrp0089p2-p377 | Thyroid P2 | ESPE2018

Effects of Thyroid Autoimmunity on Non-Alcoholic Fatty Liver Disease in Euthyroid Girls with Hashimoto’s Thyroiditis

İşguven Pınar , Ersavaş Dilek , Ersavaş Mehmet , Elmas Bahri

Introduction and Aim: The aim of this study was to investigate whether autoimmune Hashimoto’s thyroiditis (HT) increases the incidence of non-alcoholic fatty liver disease (NAFLD). In addition, the relationship between autoimmunity and the following factors was evaluated: Body Mass Index (BMI), body parameters measured by Bioelectric Impedance Analysis (BIA), and metabolic syndrome parameters.Methods: 43 newly diagnosed euthyroid girls with HT (14.4...

hrp0082p3-d3-788 | Fat Metabolism & Obesity (2) | ESPE2014

Erythrocyte Sedimentation Rate and CRP Levels in Childhood Obesity

Ersu Dilek Ozcelik , Seren Lale , Mutlu Rahime Gul Yesiltepe , Kirmizibekmez Heves

Background: Childhood obesity is one of the most important public health problems at 21st century. Obesity is an inflammatory process that leads to the impairment of health. Increasing prevalence of obesity will be a worldwide problem in the next generation, leading to serious health care and economical burden.Objective and hypotheses: The aim of this study was to investigate the relationship between childhood obesity and erythrocyte sedimentation rate a...