hrp0084p3-752 | Diabetes | ESPE2015

The Long-Term Insulin Management with Premixed Insulin in Neonates and Infants with Diabetes

Doneray Hakan , Yalcinoz Muhammet Oktay

Objectives: To describe a new therapy protocol for the long-term insulin management in neonates and infants with diabetes.Methods: All the infants were fed with 3 hours intervals. The patients were started insulin therapy with 0.6 U/kg per day divided equally into four doses. All the insulin doses were given as premixed insulin (25% insulin lispro and 75% neutral protamine Hagedorn (NPH) insulin) when the number of breast feed was more than three during ...

hrp0092p3-235 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Leydig Cell Hypoplasia in Three Siblings in the Same Family

Doneray Hakan , Ozden Ayse , Yakar Omer

Background: Leydig cell hypoplasia (LCH) is a rare disease and one of the causes of male disorder of sexual differentiation (DSD). Inactivating mutations in the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) gene can produce LCH. In this poster, we present three siblings with LCH based on the clinical and laboratory findings and the molecular diagnosis.Cases: A seven-year-old child was brought to our hospita...

hrp0089p3-p011 | Adrenals and HPA Axis P3 | ESPE2018

Severe Hyponatraemia with Absence of Hyperkalaemia in a Patient with Addison’s Disease

Doneray Hakan , Ozden Ayse , Kizilelma Nagihan Erol

Objective: Autoimmunity of the adrenal gland, also known as Addison’s disease, is characterised by cell mediated immune destruction of the adrenal cortex. We present a child with Addison’s disease who has severe hyponatraemia and normokalemia, which led to an inappropriately low index of suspicion initially at presentation.Case: A 12-year-old boy diagnosed with adrenal deficiency was admitted to hospital with 2 weeks of vomiting, fatigue and we...

hrp0089p3-p234 | Growth & Syndromes P3 | ESPE2018

Hepatic Glycogen Synthasedeficiency Associated with Growth Hormone Deficiency: A Case Report

Doneray Hakan , Ozden Ayse , Tosun Ilker

Objective: Type 0 glycogen storage disease (GSD0) is caused by deficiency of the hepatic isoform of glycogen synthase. Growth hormone deficiency in this disorder has not been reported.Case: A two-year old girl who had suffered from occasional morning convulsions was admitted to our clinic. Her length and body weight were measured as 80 cm (−2.4 S.D.) and 11.3 kg (−1.3 SD), respectively. Physical examination was unremarkable. Me...

hrp0086p2-p862 | Syndromes: Mechanisms and Management P2 | ESPE2016

Dopamine Beta-Hydroxylase Deficiency Leading to Growth Hormone Deficiency

Doneray Hakan , Ozden Ayse , Yesilcibik Remziye Seda

Background: Dopamine beta-hydroxylase (DBH) deficiency is characterized by lack of sympathetic noradrenergic function. Affected individuals exhibit profound deficits in autonomic regulation of cardiovascular function. DBH deficiency is a congenital disorder; however, the diagnosis is not generally recognized until late childhood. In this report, we present a case with DBH deficiency leading to growth hormone deficiency.Case: A ten year old girl who has b...

hrp0095t16 | Section | ESPE2022

The Relationship Between Leptin, Kisspeptin, Irisin, Myostatin and Omentin Levels and Fat Tissue at Puberty

Başak Polat Zeliha , Orbak Zerrin , Doneray Hakan , Ozturk Nurinnisa

Introduction: The hypothalamo-pituitary system is activated as puberty begins and GnRH release occurs as well as the synthesis of many hormones. These hormones cause changes on muscle development, body fat distribution. In this study, changes in miyostatin, irisin, kisspeptin, omentin and leptin levels and the relationship of these changes with physical properties and fat tissue were investigated.Material and Method: A t...

hrp0092p3-61 | Diabetes and Insulin | ESPE2019

The Effect of Fibroblast Growth Factor 23 on Serum Phosphorus Level in Children with Diabetic Ketoacidosis

Doneray Hakan , Ozay Mustafa , Ozden Ayse , Ozturk Nurinnisa , Orbak Zerrin

Aim: The pathophysiology of developing hypophosphatemia in children with diabetic ketoacidosis (DKA) has not been sufficiently elucidated. Fibroblast Growth Factor 23 (FGF23) is a hormone that causes phosphate excretion from the kidneys. The increase of FGF23 in children with DKA may explain the pathophysiology of hypophosphatemia in these children. The aim of our study was to investigate the effect of serum FGF23 on serum phosphorus level in children with DKA...

hrp0089p2-p373 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P2 | ESPE2018

Prevalence and Ethiologic Factors of Hirsutism in Adolescents

Kaplan Nılgun , Orbak Zerrin , Doneray Hakan

Aim: To investigate the prevalence of hirsutism among adolescents using the modified Ferriman-Gallway (FG) Scale and to determine etiological factors in childen with hirsutism.Materials and methods: The study was in 2380 female adolescents aged 12–18 years. The modified FG score was used in the diagnosis and monitoring of hirsutism. Scores of 8 or above were regarded as hirsutism. Two hundred thirty-three volunteers determined as having hirsutism we...

hrp0086p2-p576 | Perinatal Endocrinology P2 | ESPE2016

The Postnatal Effect of Serum Vitamin D Binding Protein on Serum Vitamin D Level

Doneray Hakan , Yesilcibik Remziye Seda , Laloglu Esra , Orbak Zerrin

Background: It is not an uncommon situation that newborns have normal serum Ca, P, Mg, ALP, and PTH levels despite low vitamin D. Serum vitamin D binding protein (VDBG) may play a role for this situation. However, there is no any study investigated the relationship between serum vitamin D and VDBP in postnatal period.Objective and hypotheses: The aim of this study is to examine the relationship between serum vitamin D level and VDBP in neonates who have ...

hrp0082p3-d2-996 | Thyroid (1) | ESPE2014

Report of a Hurthle Cell Neoplasm in a Boy

Orbak Zerrin , Cayir Atilla , Doneray Hakan , Oral Akgun , Gursan Nesrin

Background: Thyroid nodules are rare in children compared to adults. Although most thyroid nodules are benign, the risk of malignancy is greater in pediatric patients.Case: We described a 10-year-old boy who presented with a right sided thyroid nodule that was 12×8 mm. He had not cervical lymphadenopathy. His fine needle aspiration biopsy cytology was benign. It was subsequently diagnosed as a Hurthle cell adenoma after thyroidectomy. In histopathol...