hrp0089fc12.2 | Diabetes and Insulin 2 | ESPE2018

Apoptosis and Oxidative Stress Markers During the Oral Glucose Tolerance Test (OGTT)

Gil Andrea Paola Rojas , Katsa Maria Efthymia , Tzortzis Nomikos , Ioannidis Anastasios , Kostopoulou Eirini , Spiliotis Bessie E

Background: In adults, insulin resistance is associated with vascular damage and progressive loss of the endothelial protective functions. Additionally, it further complicates the micro- and macro- vascular environment through increasing oxidative stress and inflammation.Aim: The purpose of this study was to evaluate how apoptosis and antioxidant markers are correlated with biochemical markers in children, during the glucose tolerance te...

hrp0084p2-402 | GH & IGF | ESPE2015

The Involvement of the Epidermal Growth Factor Receptor in the Successful GH Signalling and the Role of p21 in the Negative Regulation of the GH/GHR and EGF/EGFR Pathways, in GH Transduction Defect

Kostopoulou Eirini , Gil Andrea Paola Rojas , Karvela Alexia , Spiliotis Bessie Eugenia

Background: GH transduction defect (GHTD) is characterised by severe short stature and impaired STAT3 phosphorylation, which is overcome by simultaneous induction of GHTD fibroblasts with 200 ng/ml GH and short interference mRNA CIS (GH200/siRNA) or with 1 000 ng/ml GH (GH1000) and is clinically expressed with ‘catch-up’ growth after rhGH treatment.Objective and hypotheses: The involvement of epidermal growth factor receptor (EGFR) in the succe...

hrp0084p2-404 | GH & IGF | ESPE2015

The Role of β-TrCP, an E3 Ubiquitin Ligase, in the Signalling of the GH and Epidermal Growth Factor Pathways in Growth Hormone Transduction Defect

Kostopoulou Eirini , Gil Andrea Paola Rojas , Karvela Alexia , Spiliotis Bessie Eugenia

Background: epidermal growth factor (EGF) stimulates cell growth and differentiation through its receptor EGFR. Cross-talking between the GH and EGF signaling pathways is important for normal cellular development. GH transduction defect (GHTD), a clinical disorder characterized by impaired STAT3 phosphorylation due to excessive GHR degradation, is caused by over-expression of the E3 ubiquitin ligase, CIS.Induction of GHTD fibroblasts with 200 ng/ml hGH (GH200) and silencing mR...

hrp0094p1-69 | Diabetes B | ESPE2021

Oxidized lipid-associated protein damage in children and adolescents with type 1 diabetes mellitus: new diagnostic/prognostic clinical markers.

Kostopoulou Eirini , Kalaitzopoulou Electra , Papadea Polyxeni , Skipitari Marianna , Gil Andrea Paola Rojas , Spiliotis Bessie , Georgiou Christos ,

Background: Type 1 diabetes mellitus (DM1), a chronic metabolic disorder of autoimmune origin, has been associated with oxidative stress (OS), which plays a central role in the onset, progression and long-term complications of DM1. The markers of OS lipid peroxidation products, lipid hydroperoxides (LOOH), and also malondialdehyde (MDA) and thiobarbituric reactive substances (TBARS) that oxidatively modify proteins (Pr) (i.e., PrMDA and PrTBARS, respectively),...

hrp0082p3-d1-763 | Fat Metabolism & Obesity | ESPE2014

Association of Lifestyle with Metabolic Syndrome in Children

Katsa Maria Efthymia , Zyga Sofia , Tsironi Maria , Ioannidis Anastasios , Sachlas Athanasios , Kolobos Petros , Magana Maria , Pistikou Anna Maria , Dimoliani Dafni Eleni Kougioumtzi , GIl Andrea Paola Rojas

Background: Metabolic syndrome (MetSyn) is defined as a group of disorders including diabetes mellitus, central obesity, dyslipidaemia, and hypertension.Aim: To investigate the role of lifestyle habits in correlation with MetSyn in children.Methods: In our research, 480 students, 6–12 years old, were participated living in Sparta–Greece. During 2011–2012, a specially designed questionnaire was used and anthropometric...

hrp0084p2-374 | Fat | ESPE2015

Lifestyle Habits and Arterial Hypertension in Children and Adolescents

Daratsianou Maria , Ioannidis Anastasios , Zyga Sofia , Koutsovitis Paraskevas , Sachlas Athanasios , Xrona Maria , Batsikoura Maria , Katsa Maria Efthymia , Magana Maria , Andronikakis Eleftherios , Gil Andrea Paola Rojas

Background: Elevated blood pressure (BP) may occur from childhood, increasing the risk for hypertension in adulthood.Aim: To investigate the effect of anthropometric characteristics and lifestyle habits in children’s and adolescents’ BP.Methods: 949 children (<12 years old) from Lakonia, 178 teenagers (12–18 years old) from Athens and 372 from Kalamata, Greece, had participated during 2011–2014. A specially ...

hrp0084p3-854 | Fat | ESPE2015

Association of Sleep Habits and Risk Factors for Metabolic Disorders in Children

Magana Maria , Zyga Sofia , Ioannidis Anastasios , Sachlas Athanasios , Katsa Maria Efthymia , Pistikou Anna Maria , Dimoliani Dafni Eleni Kougioumtzi , Daratsianou Maria , Kolovos Petros , Gil Andrea Paola Rojas

Background: Sleep is a complex and essential biological process that is required on a daily basis for all humans, playing a vital role in the maintenance of the homeostasis in short and long term.Aims and objectives: To investigate the role of sleep hours in correlation with risk factors for metabolic disorders in a children population.Methods: The program was implemented in 949 children (5–12 years old) living in Sparta-Greec...

hrp0084p3-883 | Fat | ESPE2015

Investigating Predisposing Factors for Childhood Obesity

Magana Maria , Routsi Kleopatra , Zyga Sofia , Panoutsopoulos George , Ioannidis Anastasios , Tsironi Maria , Pistikou Anna-Maria , Kougioumtzi-Dimoliani Dafni-Eleni , Kolovos Petros , Gil Andrea Paola Rojas

Background: Childhood obesity is considered to be an epidemic in developed countries that can negatively affect children’s health and psychology.Aims and objectives: To investigate the nutritional and environmental factors that lead to the presence of childhood obesity and its complications.Methods: A total of 949 students, 3–12 years old, living in Sparta–Greece, have participated in our research. Their lifestyle an...