hrp0095p1-466 | Fat, Metabolism and Obesity | ESPE2022

Lipidemic Profile of Adolescents with Obesity After Oral Administration of Krokos Kozanis (Crocus Sativus): A Pilot Clinical Study

P Kotanidou Eleni , Rengina Tsinopoulou Vasiliki , Giza Styliani , Ntouma Stergianna , Sakellari Eleni , Galli-Tsinopoulou Assimina

Introduction: Adolescent obesity is often characterized by comorbidities with cardiovascular effects in adulthood. Treatment options for these conditions are limited during adolescence. Basic research in animals and clinical data in adults have shown that Crocus Sativus (Krokos Kozanis) has a beneficial effect on dyslipidemia, obesity and type 2 diabetes.Aim: The study of the lipidemic profile in fasting state, in adoles...

hrp0095p2-236 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Challenges in The Era of Covid-19: Starting from The Clinical Examination

Giza Styliani , Konstantinos Sidiropoulos Theodoros , Douma Stergiana , Regina Tsinopoulou Vasiliki , P Kotanidou Eleni , Galli-Tsinopoulou Assimina

Introduction: Physical examination remains the cornerstone of medical practice. However, its importance has been underestimated during COVID-19 pandemic because of concerns related to exposure risk and use of personal protective equipment. Solitary median maxillary central incisor (SMMCI) may be an isolated clinical trait or associated with other anomalies and endocrine pathologies including hypopituitarism, hypothyroidism, isolated growth hormone (GH) deficie...

hrp0092fc7.1 | Diabetes and Insulin Session 2 | ESPE2019

Deployment of a Predictive Model Based on CpG Methylation Haplotypes Analysis on the Insulin Gene Promoter, in a Cohort of Children and Adolescents with Type 1 Diabetes

Kotanidou Eleni P , Mouzaki Konstantina , Chouvarda Ioanna , Koutsiana Elisavet , Kosvyra Alexandra , Giza Styliani , Galli-Tsinopoulou Assimina

Background: Cytosine-guanine(CpGs) sites in molecules identified as methylated or unmethylated; the combination of them in the genetic sequence of an individual includes a methylation haplotype (methyl-haplotype) for a specific locus. The insulin gene promoter(IGP) is highly regulated by methylation mechanisms, which lead to alteration of gene expression.Aim: To identify IGPmethyl-haplotypes among children/adolescents wi...

hrp0086p1-p930 | Thyroid P1 | ESPE2016

Seasonality of Month of Birth in Children and Adolescents with Hashimoto Thyroiditis

Kyrgios Ioannis , Giza Styliani , Kotanidou Eleni , Maggana Ioanna , Galli-Tsinopoulou Assimina

Background: A number of studies have previously described seasonality of birth in children with type 1 diabetes, thus suggesting that the autoimmune process may begin during fetal development. However, there is a lack of data regarding autoimmune thyroid disease in childhood.Objective and hypotheses: The aim of this study was to analyse the seasonal birth month pattern in young patients with Hashimoto thyroiditis and compare it with that of youth healthy...

hrp0095p2-161 | Growth and Syndromes | ESPE2022

Noonan syndrome-like disorder with loose anagen hair (NSLH1): watch out for the red hair

Tsinopoulou Vasiliki-Rengina , Giza Styliani , Kotanidou Eleni , Douma Stergiana , Michailidou Vasiliki , Tsipi Alexandra , Fidani Styliani , Galli-Tsinopoulou Assimina

Introduction: Noonan syndrome-like disorder with loose anagen hair (NSLH1), also known as Mazzanti syndrome (OMIM#607721) is a RASopathy due to missense mutation (c.4A>G, p.Ser2Gly) in SHOCK2 gene. The NSHL1 is characterized by Noonan syndrome-like facial dysmorphisms, easily pluckable, slow growing, sparse and thin hair, growth retardation, variable neurocognitive impairment and cardiac anomalies.Aim: To present an a...

hrp0089p1-p054 | Diabetes & Insulin P1 | ESPE2018

CpG Methylation Status Changes within the Protein Tyrosine Phosphatase Non-Receptor Type 22 Gene Promoters in Children and Adolescents of Greek Origin with Type 1 Diabetes

Mouzaki Konstantina , Giza Styliani , Kotanidou Eleni P. , Fragou Aikaterini , Taousani Maria , Eboriadou-Petikopoulou Maria , Tzimagiorgis Georgios , Galli-Tsinopoulou Assimina

Introduction: Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a well-established genetic locus of type 1 diabetes (T1D). The aim of the present study is to compare the methylation level of PTPN22 between children and adolescents of Greek origin with T1D and healthy controls.Patients and Methods: Twenty T1D participants and 20 age-/gender-matched healthy youngsters were enrolled. DNA was extracted from white blood cells, the...

hrp0097p1-75 | Fat, Metabolism and Obesity | ESPE2023

Newer anthropometric indexes predicting insulin resistance in Greek children and adolescents with overweight and obesity

Giza Styliani , Ntouma Stergianna , P Kotanidou Eleni , Rengina Tsinopoulou Vasiliki , Kampani Eleftheria , I Sakellari Eleni , Galli-Tsinopoulou Assimina

Introduction: Body mass index (BMI) and waist circumference (WC) are the main anthropometric measures of obesity. However, their inability to take into account body fat distribution raises queries for their predictive value of insulin resistance (IR) in youth.Aim: The aim of this study is to compare BMI and WC with latest anthropometric indices in the assessment of IR in a paediatric Greek population with overweight and ...

hrp0092p2-301 | Thyroid | ESPE2019

Acute-Onset Peripheral Polyneuropathy in a 12-Year-Old Girl Due to Hashimoto Thyroiditis: Traps in the Diagnosis

Giza Styliani , Tychalas Athanasios , Gulordava Athina , Markidou Sophia , Litou Eleni , Kotanidou Eleni P , Rengina Tsinopoulou Vassiliki , Mouzaki Konstantina , Evangeliou Athanasios , Papadopoulou-Legbelou Kyriaki , Galli-Tsinopoulou Assimina

Introduction: Thyroid dysfunction may cause a wide range of neurological disorders in children. Hypothyroidism is associated with peripheral nerve demyelination. However, minimal data are available in pediatric population.Purpose: To describe a case of newly diagnosed Hashimoto thyroiditis (HT) suffering acute-onset rapidly progressive peripheral polyneuropathy.Case Report: A 12-ye...

hrp0089rfc12.5 | Diabetes and Insulin 2 | ESPE2018

Insulin Gene Promoter Methylation Status in Greek Children and Adolescents with Type 1 Diabetes

Mouzaki Konstantina , Kotanidou Eleni P , Fragou Aikaterini , Giza Styliani , Kleisarchaki Angeliki N , Tsinopoulou Vasiliki Rengina , Serbis Anastasios , Tzimagiorgis Georgios , Galli-Tsinopoulou Assimina

Introduction: Insulin (INS) gene is reported to be the most important gene involved in Type 1 Diabetes (T1D); its expression is inversely correlated with methylation at CpG sites. Hypermethylated primers are associated with decreased expression.Aim: The present study aims to investigate possible differences in DNA methylation pattern between T1D youngsters and healthy controls.Patients and Methods: Twenty T1D parti...

hrp0089p2-p066 | Diabetes & Insulin P2 | ESPE2018

Prothrombin Gene 20210A Mutation Heterozygosity and MTHFR Gene C677T Mutation Homozygosity Detected in a Male Toddler Experiencing Femoral Venous Thrombosis During Diabetic Ketoacidosis

Kleisarchaki Angeliki N , Giza Styliani , Nikolaidou Olga , Mouzaki Konstantina , Kotanidou Eleni P , Litou Eleni , Rengina Tsinopoulou Vasiliki , Papadakis Emmanouil , Galli-Tsinopoulou Assimina

Introduction: Diabetic ketoacidosis (DKA) as an inflammatory state combined with the disruption of the normal coagulation cascade can lead patients to an increased risk of thrombosis. Especially, patients that are genetically susceptible to thrombosis could develop deep venous thrombosis (DVT) due to inflammation, dehydration, and hyperviscosity secondarily to DKA. It is noteworthy that children with DKA who underwent central venous catheter placement could develop DVT, especi...